Zobrazeno 1 - 10
of 173
pro vyhledávání: '"John Weroha"'
Autor:
Annapoorna Venkatachalam, Cristina Correia, Kevin L. Peterson, Xianon Hou, Paula A. Schneider, Annabella R. Strathman, Karen S. Flatten, Chance C. Sine, Emily A. Balczewski, Cordelia D. McGehee, Melissa C. Larson, Laura N. Duffield, X. Wei Meng, Nicole D. Vincelette, Husheng Ding, Ann L. Oberg, Fergus J. Couch, Elizabeth M. Swisher, Hu Li, S. John Weroha, Scott H. Kaufmann
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid tumors, including platinum-resistant high grade serous ovarian cancer (HGSOC). Howev
Externí odkaz:
https://doaj.org/article/10416db1db3e4dd388e15b58bcaf44a8
Autor:
Jesus Gonzalez-Bosquet, S. John Weroha, Jamie N. Bakkum-Gamez, Amy L. Weaver, Michaela E. McGree, Sean C. Dowdy, Abimbola O. Famuyide, Benjamin R. Kipp, Kevin C. Halling, Siddhartha Yadav, Fergus J. Couch, Karl C. Podratz
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
ObjectiveTo identify high-risk disease in clinicopathologic low-risk endometrial cancer (EC) with high microsatellite instability (MSI-H) or no specific molecular profile (NSMP) and therapeutic insensitivity in clinicopathologic high-risk MSI-H/NSMP
Externí odkaz:
https://doaj.org/article/32b034603ff54448b98bb03612a864b7
Autor:
Jaime I. Davila, Pritha Chanana, Vivekananda Sarangi, Zachary C. Fogarty, S. John Weroha, Ruifeng Guo, Ellen L. Goode, Yajue Huang, Chen Wang
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Background DNA polymerase epsilon (POLE) is encoded by the POLE gene, and POLE-driven tumors are characterized by high mutational rates. POLE-driven tumors are relatively common in endometrial and colorectal cancer, and their presence is inc
Externí odkaz:
https://doaj.org/article/a1e4d82a71d04a0598c859ca14dca1e2
Autor:
Max J. Cotler, Khalil B. Ramadi, Xiaonan Hou, Elena Christodoulopoulos, Sebastian Ahn, Ashvin Bashyam, Huiming Ding, Melissa Larson, Ann L. Oberg, Charles Whittaker, Oliver Jonas, Scott H. Kaufmann, S. John Weroha, Michael J. Cima
Publikováno v:
Translational Oncology, Vol 21, Iss , Pp 101427- (2022)
Long-term treatment outcomes for patients with high grade ovarian cancers have not changed despite innovations in therapies. There is no recommended assay for predicting patient response to second-line therapy, thus clinicians must make treatment dec
Externí odkaz:
https://doaj.org/article/c99a7e1699694096a41da7ceb49b727a
Autor:
Katherine C. Kurnit, Meghan Steiner, Ricardo R. Lastra, S. John Weroha, John Cursio, Ernst Lengyel, Gini F. Fleming, Suzanne D. Conzen
Publikováno v:
Gynecologic Oncology Reports, Vol 41, Iss , Pp 100987- (2022)
Glucocorticoid receptor can be associated with poor prognosis among a variety of solid tumors in the absence of other nuclear hormone receptors. Our objective was to characterize differences in glucocorticoid receptor (GR), estrogen receptor (ER), pr
Externí odkaz:
https://doaj.org/article/74f001dec45142a8b94f7bb8d13439d0
Autor:
Ann L. Oberg, Ethan P. Heinzen, Xiaonan Hou, Mariam M. Al Hilli, Rachel M. Hurley, Andrea E. Wahner Hendrickson, Krista M. Goergen, Melissa C. Larson, Marc A. Becker, Jeanette E. Eckel-Passow, Matthew J. Maurer, Scott H. Kaufmann, Paul Haluska, S. John Weroha
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Repeated measures studies are frequently performed in patient-derived xenograft (PDX) models to evaluate drug activity or compare effectiveness of cancer treatment regimens. Linear mixed effects regression models were used to perform statist
Externí odkaz:
https://doaj.org/article/ff6b9ed53489469fac350642c746a06e
Autor:
Matthew S. Block, Allan B. Dietz, Michael P. Gustafson, Kimberly R. Kalli, Courtney L. Erskine, Bahaaeldin Youssef, Geraldine V. Vijay, Jacob B. Allred, Kevin D. Pavelko, Michael A. Strausbauch, Yi Lin, Megan E. Grudem, Aminah Jatoi, Carolyn M. Klampe, Andrea E. Wahner-Hendrickson, S. John Weroha, Gretchen E. Glaser, Amanika Kumar, Carrie L. Langstraat, Mary L. Solseth, Michael C. Deeds, Keith L. Knutson, Martin J. Cannon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The folate receptor alpha (FRα) is overexpressed in the majority of high-grade serous ovarian cancers and has been proposed as a candidate vaccine antigen. Here the authors report the safety and immunogenicity of Th17-inducing dendritic cells pulsed
Externí odkaz:
https://doaj.org/article/a2fbef783d684ad39f4729cec68b77ca
Publikováno v:
Gynecologic Oncology Reports, Vol 39, Iss , Pp 100923- (2022)
Non-gestational choriocarcinoma is a rare and aggressive germ cell tumor. Here we present the case of a post-menopausal 49-year-old woman who presented with metastatic disease and initially achieved a complete radiographic and biomarker response with
Externí odkaz:
https://doaj.org/article/7892a6384fb943bbb3801ffa1b53894f
Autor:
Jesus Gonzalez-Bosquet, S John Weroha, Jamie N Bakkum-Gamez, Amy L Weaver, Michaela E McGree, Sean C Dowdy, Abimbola O Famuyide, Benjamin R Kipp, Kevin C Halling, Siddhartha Yadav, Fergus J Couch, Karl C Podratz
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0278408 (2022)
In endometrial cancer, occult high-risk subtypes (rooted in histomorphologically low-risk disease) with insensitivity to adjuvant therapies impede improvements in therapeutic efficacy. Therefore, we aimed to assess the ability of molecular high-risk
Externí odkaz:
https://doaj.org/article/70ac29b94c314af7a0ea660185f64472
Autor:
Lixia Wang, John Powderly, Tanios Bekaii-Saab, Susanna Ulahannan, Ngan Nguyen, Deborah Doroshow, Yan Xing, Mark Whidden, Carl Millward, Jonathan Benjamin, S John Weroha, Frances Valdes-Albini, Kimberly Walter, Andrew Wrong, Paul Del Castillo, Steven Isakoff
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/03e0ba082d824a39b3cb3ba0fcab7adb