Zobrazeno 1 - 10
of 18
pro vyhledávání: '"John Washbrook"'
Publikováno v:
Biotechnology Progress. 21:486-497
This paper presents the application of a decision-support tool, SIMBIOPHARMA, for assessing different manufacturing strategies under uncertainty for the production of biopharmaceuticals. SIMBIOPHARMA captures both the technical and business aspects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328aee679b16bbf0d488ceb49be83d0b
https://doi.org/10.1021/bp049692b
https://doi.org/10.1021/bp049692b
Autor:
Ai Chye Lim, Yuhong Zhou, Andrew Sinclair, John Washbrook, Brendan Cormick Fish, Suzanne S. Farid, Nigel J. Titchener-Hooker, Richard Francis
Publikováno v:
Biotechnology Progress. 21:1231-1242
Biopharmaceutical manufacture is subject to numerous risk factors that may affect operational costs and throughput. This paper discusses the need for incorporating such uncertainties in decision-making tools in order to reflect the inherent variabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deef6c616bccfcc812ff0f558f3237f8
https://doi.org/10.1021/bp049578t
https://doi.org/10.1021/bp049578t
Publikováno v:
Computers & Chemical Engineering. 31:1141-1158
This paper presents the implementation of a conceptual framework, for modelling a biopharmaceutical manufacturing plant, into a prototype decision-support tool, S im B iopharma . The tool's scope covers the ability to evaluate manufacturing alternati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88047f783303026f3268aa60e674f774
https://doi.org/10.1016/j.compchemeng.2006.10.020
https://doi.org/10.1016/j.compchemeng.2006.10.020
Publikováno v:
Food and Bioproducts Processing. 84:84-89
A key issue within the biopharmaceutical industry is the potential feasibility of retrofits as a means of reducing operating costs and improving process efficiency. This paper presents a framework, designed to capture both process and business aspect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8ae5e97003c582679a921148b583ab5
https://doi.org/10.1205/fbp.05123
https://doi.org/10.1205/fbp.05123
Autor:
Yuhong Zhou, Ai Chye Lim, John Washbrook, Mustafa A. Mustafa, Nigel J. Titchener-Hooker, Steve Berezenko, Philip Harvey Morton, Suzanne S. Farid
Publikováno v:
Biotechnology Progress. 20:1096-1102
Conventionally, software tools for the design of bioprocesses have provided only limited business-related information for decision-making. There is an industrial need to investigate manufacturing options and to gauge the impact of various decisions f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::669cd3b6f8feede6eca35977def2e125
https://doi.org/10.1021/bp034377v
https://doi.org/10.1021/bp034377v
Publikováno v:
Computers & Chemical Engineering. 28:727-735
This paper discusses the need for decisional-support tools in the biotech industry and presents the configuration of a prototype tool for modelling bioprocesses and regulatory compliance activities such as quality control (QC), quality assurance (QA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa22a495899a2d2cadf90348d42e4dd3
https://doi.org/10.1016/j.compchemeng.2004.02.013
https://doi.org/10.1016/j.compchemeng.2004.02.013
Publikováno v:
IFAC Proceedings Volumes. 34:161-165
A decision-support tool is presented for modelling both the technical and business aspects of biopharmaceutical manufacture. The use of the tool for risk analysis is demonstrated through a case study that uses Monte Carlo simulation to imitate the ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7176cce0006350c40b60013e553999c5
https://doi.org/10.1016/s1474-6670(17)34213-1
https://doi.org/10.1016/s1474-6670(17)34213-1
Autor:
John Washbrook, Elpida T. Keravnou
Publikováno v:
Computational Intelligence. 17:87-131
Diagnostic problem solving aims to account for, or explain, a malfunction of a system (human or other). Any plausible potential diagnostic solution must satisfy some minimum criteria relevant to the application. Often there will be several plausible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372e60acb732081b2b746aff34336353
https://doi.org/10.1111/0824-7935.00135
https://doi.org/10.1111/0824-7935.00135
Publikováno v:
Biotechnology and bioengineering. 93(4)
Fed-batch and perfusion culture dominate mammalian cell culture production processes. In this paper, a decision-support tool was employed to evaluate the economic feasibility of both culture modes via a case study based upon the large-scale productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b1c77a6e64ad8e6c9327e7c41f1713
https://pubmed.ncbi.nlm.nih.gov/16259001
https://pubmed.ncbi.nlm.nih.gov/16259001
Publikováno v:
Biotechnology progress. 21(4)
This paper reports how financial and operational results from bioprocess simulations can be combined with other criteria pertinent to decision-making predictions to provide a more holistic approach to the evaluation of biomanufacturing alternatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414167bfc91655c298c3a0fbdb00814f
https://pubmed.ncbi.nlm.nih.gov/16080700
https://pubmed.ncbi.nlm.nih.gov/16080700