Zobrazeno 1 - 4
of 4
pro vyhledávání: '"John Walter Liebeschuetz"'
Autor:
John Walter Liebeschuetz
Publikováno v:
Journal of medicinal chemistry. 64(11)
An analysis of the rotatable bond geometry of drug-like ligand models is reported for high-resolution (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5133827f59ed1a6b37a2b20aba961541
https://pubmed.ncbi.nlm.nih.gov/34060310
https://pubmed.ncbi.nlm.nih.gov/34060310
Autor:
Jothirajah Marimuthu, Mark W. Farmen, Wayne W. Weber, Stuart Donald Jones, Kyle Ja, Michael Robert Wiley, John Walter Liebeschuetz, David Birenbaum Engel, Jeffrey K. Smallwood, Jeffrey B. Franciskovich, Christopher W. Murray, John Joseph Masters, Gerald F. Smith, Scott Martin Sheehan, Stephen Clinton Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2255-2259
A novel isonitrile derivative was synthesized and used in an Ugi four component coupling reaction to explore aryl group substitution effects on inhibition of the coagulation cascade serine protease factor Xa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19782e716ea56f919eb80077ac5b0555
https://doi.org/10.1016/s0960-894x(03)00462-1
https://doi.org/10.1016/s0960-894x(03)00462-1
Autor:
Jonathan Michael Ernest Roscoe, Bohdan Waszkowycz, Stuart Donald Jones, Andrew David Rimmer, John Walter Liebeschuetz, Jacqui Mahler, Pauline Mary Welsh, William Alexander Wylie, Phillip John Morgan, Harry Martin, KW Wilkinson, Christopher W. Murray, Stephen Clinton Young, Leo Brady
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:733-736
Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494d018620c58c91d8413e47e877e1f2
https://doi.org/10.1016/s0960-894x(01)00042-7
https://doi.org/10.1016/s0960-894x(01)00042-7
Autor:
Pauline Mary Welsh, Leo Brady, Andrew David Rimmer, William Alexander Wylie, Jonathan Michael Ernest Roscoe, Stuart Donald Macclesfield Jones, KW Wilkinson, Phillip John Morgan, Harry Martin, Jacqui Mahler, Stephen Clinton Young, Bohdan Waszkowycz, Christopher William Murray, John Walter Liebeschuetz
Publikováno v:
Journal of medicinal chemistry. 45(6)
In silico screening of combinatorial libraries prior to synthesis promises to be a valuable aid to lead discovery. PRO_SELECT, a tool for the virtual screening of libraries for fit to a protein active site, has been used to find novel leads against t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c097f97a62e4fd862adf07797341583
https://pubmed.ncbi.nlm.nih.gov/11881991
https://pubmed.ncbi.nlm.nih.gov/11881991