Zobrazeno 1 - 10
of 410
pro vyhledávání: '"John W.M. Martens"'
Autor:
Bircan Coban, Zi Wang, Chen-yi Liao, Klara Beslmüller, Mieke A.M. Timmermans, John W.M. Martens, Jasmijn H.M. Hundscheid, Bram Slutter, Annelien J.M. Zweemer, Elsa Neubert, Erik H.J. Danen
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109738- (2024)
Summary: Tumor tissues often contain high extracellular adenosine, promoting an immunosuppressed environment linked to mesenchymal transition and immune evasion. Here, we show that loss of the epithelial transcription factor, GRHL2, triggers NT5E/CD7
Externí odkaz:
https://doaj.org/article/7db94f8d0efd4c47abfa7e432f94c9c3
Autor:
Wesley S. van de Geer, Ron H.J. Mathijssen, Job van Riet, Neeltje Steeghs, Mariette Labots, Carla van Herpen, Lot A. Devriese, Vivianne C.G. Tjan-Heijnen, Emile E. Voest, Stefan Sleijfer, John W.M. Martens, Edwin Cuppen, Harmen J.G. van de Werken, Sander Bins
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114210- (2023)
Drug resistance is a perpetual problem in cancer therapy with many underlying mechanisms. Alterations in drug transport over the cancer cell membrane can severely alter intratumoral drug exposure, contributing to resistance. Here, we present the soma
Externí odkaz:
https://doaj.org/article/dfde034a6bb040089d45cdf4f8ef6c58
Autor:
Tiansheng Zhu, Yi Zhu, Yue Xuan, Huanhuan Gao, Xue Cai, Sander R. Piersma, Thang V. Pham, Tim Schelfhorst, Richard R.G.D. Haas, Irene V. Bijnsdorp, Rui Sun, Liang Yue, Guan Ruan, Qiushi Zhang, Mo Hu, Yue Zhou, Winan J. Van Houdt, Tessa Y.S. Le Large, Jacqueline Cloos, Anna Wojtuszkiewicz, Danijela Koppers-Lalic, Franziska Böttger, Chantal Scheepbouwer, Ruud H. Brakenhoff, Geert J.L.H. van Leenders, Jan N.M. Ijzermans, John W.M. Martens, Renske D.M. Steenbergen, Nicole C. Grieken, Sathiyamoorthy Selvarajan, Sangeeta Mantoo, Sze S. Lee, Serene J.Y. Yeow, Syed M.F. Alkaff, Nan Xiang, Yaoting Sun, Xiao Yi, Shaozheng Dai, Wei Liu, Tian Lu, Zhicheng Wu, Xiao Liang, Man Wang, Yingkuan Shao, Xi Zheng, Kailun Xu, Qin Yang, Yifan Meng, Cong Lu, Jiang Zhu, Jin'e Zheng, Bo Wang, Sai Lou, Yibei Dai, Chao Xu, Chenhuan Yu, Huazhong Ying, Tony K. Lim, Jianmin Wu, Xiaofei Gao, Zhongzhi Luan, Xiaodong Teng, Peng Wu, Shi'ang Huang, Zhihua Tao, Narayanan G. Iyer, Shuigeng Zhou, Wenguang Shao, Henry Lam, Ding Ma, Jiafu Ji, Oi L. Kon, Shu Zheng, Ruedi Aebersold, Connie R. Jimenez, Tiannan Guo
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 18, Iss 2, Pp 104-119 (2020)
To address the increasing need for detecting and validating protein biomarkers in clinical specimens, mass spectrometry (MS)-based targeted proteomic techniques, including the selected reaction monitoring (SRM), parallel reaction monitoring (PRM), an
Externí odkaz:
https://doaj.org/article/272efeb3b0fc4ac9a3ba92b579d82fb4
Autor:
Dinja T. Kruger, Maurice P.H.M. Jansen, Inge R.H.M. Konings, Wouter M. Dercksen, Agnes Jager, Jamal Oulad Hadj, Stefan Sleijfer, John W.M. Martens, Epie Boven
Publikováno v:
Molecular Oncology, Vol 14, Iss 3, Pp 490-503 (2020)
We determined whether progression‐free survival (PFS) in metastatic breast cancer (MBC) patients receiving everolimus plus exemestane (EVE/EXE) varies depending on circulating tumour DNA (ctDNA) characteristics. Baseline plasma cell‐free DNA (cfD
Externí odkaz:
https://doaj.org/article/131bba09d28a4cc7af7300b46f189229
Autor:
Diana Ramirez-Ardila, A. Mieke Timmermans, Jean A. Helmijr, John W.M. Martens, Els M.J.J. Berns, Maurice P.H.M. Jansen
Publikováno v:
Translational Oncology, Vol 10, Iss 5, Pp 854-866 (2017)
INTRODUCTION: While mutations in PIK3CA are most frequently (45%) detected in luminal breast cancer, downstream PI3K/AKT/mTOR pathway activation is predominantly observed in the basal subtype. The aim was to identify proteins activated in PIK3CA muta
Externí odkaz:
https://doaj.org/article/6657e8cf443844d6a34dbdef52a85d3d
Autor:
Nick Beije, Wendy Onstenk, Jaco Kraan, Anieta M. Sieuwerts, Paul Hamberg, Luc Y. Dirix, Anja Brouwer, Felix E. de Jongh, Agnes Jager, Caroline M. Seynaeve, Ngoc M. Van, John A. Foekens, John W.M. Martens, Stefan Sleijfer
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 11, Pp 647-653 (2016)
BACKGROUND: Preclinical and clinical studies have reported that human epidermal growth factor receptor 2 (HER2) overexpression yields resistance to endocrine therapies. Here the prevalence and prognostic impact of HER2-positive circulating tumor cell
Externí odkaz:
https://doaj.org/article/2fc277ad94754fb3a632334527cbac9b
Autor:
Tommaso De Marchi, Ning Qing Liu, Christoph Sting, Marcel Smid, Mila Tjoa, René B.H. Braakman, Theo M. Luider, John A. Foekens, John W.M. Martens, Arzu Umar
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 399-402 (2015)
We here describe two proteomic datasets deposited in ProteomeXchange via PRIDE partner repository [1] with dataset identifiers PXD000484 (defined as “training”) and PXD000485 (defined as “test”) that have been used for the development of a ta
Externí odkaz:
https://doaj.org/article/c2865377921c49f1b603beb2360ca2ec
Autor:
Marie Colombe Agahozo, Mieke A.M. Timmermans, Hein F.B.M. Sleddens, Renée Foekens, Anita M.A.C. Trapman-Jansen, Carolien P. Schröder, Elise van Leeuwen-Stok, John W.M. Martens, Winand N.M. Dinjens, Carolien H.M. van Deurzen
Publikováno v:
Cancers, Vol 12, Iss 3, p 631 (2020)
Loss of Y-chromosome (LOY) is associated with increased cancer mortality in males. The prevalence of LOY in male breast cancer (BC) is unknown. The aim of this study is to assess the presence and prognostic effect of LOY during male BC progression. W
Externí odkaz:
https://doaj.org/article/6cde6320d3f94880b15cbe8704692132
Autor:
Anders Sundqvist, Oleksandr Voytyuk, Mohamed Hamdi, Herman E. Popeijus, Corina Bijlsma- van der Burgt, Josephine Janssen, John W.M. Martens, Aristidis Moustakas, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam
Publikováno v:
Cells, Vol 8, Iss 12, p 1481 (2019)
Transforming growth factor-β (TGFβ) has both tumor-suppressive and tumor-promoting effects in breast cancer. These functions are partly mediated through Smads, intracellular transcriptional effectors of TGFβ. Smads form complexes with other DNA-bi
Externí odkaz:
https://doaj.org/article/e3a287ed25a94d85a0b0275491f108e6
Autor:
Ingeborg E. de Kruijff, Anieta M. Sieuwerts, Wendy Onstenk, Jaco Kraan, Marcel Smid, Mai N. Van, Michelle van der Vlugt-Daane, Esther Oomen-de Hoop, Ron H.J. Mathijssen, Martijn P. Lolkema, Ronald de Wit, Paul Hamberg, Hielke J. Meulenbeld, Aart Beeker, Geert-Jan Creemers, John W.M. Martens, Stefan Sleijfer
Publikováno v:
Cancers, Vol 11, Iss 8, p 1212 (2019)
(1) Background: Markers identifying which patients with metastatic, castration-resistant prostate cancer (mCRPC) will benefit from cabazitaxel therapy are currently lacking. Therefore, the aim of this study was to identify markers associated with out
Externí odkaz:
https://doaj.org/article/be6f8d4ca00441f7bda0749974eb8910