Zobrazeno 1 - 10
of 18
pro vyhledávání: '"John W. Yates"'
Autor:
Pieter H.E. Groot, Nigel J. Pearce, John W. Yates, Claire Stocker, Charles Sauermelch, Christopher P. Doe, Robert N. Willette, Alan Olzinski, Tambra Peters, Denise d'Epagnier, Kathleen O. Morasco, John A. Krawiec, Christine L. Webb, Karpagam Aravindhan, Beat Jucker, Mark Burgert, Chun Ma, Joseph P. Marino, Jon L. Collins, Colin H. Macphee, Scott K. Thompson, Michael Jaye
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2182-2191 (2005)
Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking, including absorption, excretion, catabolism, and cellular efflux, and possess both anti-inflammatory and antidiabetic actions. A
Externí odkaz:
https://doaj.org/article/a93b77eb6ebb42eda0f367c3bb33cfa8
Autor:
Ashley Null, John W. Yates III
A Clear Vision for What It Means to Be Anglican Today Conceived under the conviction that the future of the global Anglican Communion hinges on a clear, welldefined, and theologically rich vision, the Reformation Anglicanism Essential Library was cre
Autor:
Jonathan R.S. Arch, Ed Wargent, Alastair Morrison, Gregory J. Murphy, Nigel J. Pearce, Carolyn A. Lister, Lynne Roxbee-Cox, Alexander J. Harper, Alejandro Abuin, Colleen M. Taylor, Andrea Llano, Stephen A. Smith, John C. Clapham, Gary B.T. Moore, Julie C. Holder, John W. Yates, Matthew P. Coghlan, Stacey L. Corcoran
Publikováno v:
Metabolism. 53:1322-1330
Glycogen synthase kinase-3 (GSK-3) protein levels and activity are elevated in skeletal muscle in type 2 diabetes, and inversely correlated with both glycogen synthase activity and insulin-stimulated glucose disposal. To explore this relationship, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800a3b5ddbe68120ca1239fec3160f79
https://doi.org/10.1016/j.metabol.2004.05.008
https://doi.org/10.1016/j.metabol.2004.05.008
Autor:
Robert W. Ward, Stacey L. Corcoran, Gregory J. Murphy, Lynne Roxbee Cox, Julie C. Holder, David Haigh, Murray J. B. Brown, Olivier Lars SmithKline Beecham Pharmaceu. Rausch, Darren Cross, Ainsley A. Culbert, John W. Yates, Matthew P. Coghlan, Kenneth J. Murray, Smith David Glynn, Alastair D. Reith, Nigel J. Pearce, David Mills, Paul S. Carter
Publikováno v:
Chemistry & Biology. 7(10):793-803
Background: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the activity of which is inhibited by a variety of extracellular stimuli including insulin, growth factors, cell specification factors and cell adhesion. Consequentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542096d4c74f656602d387c9e0a7bdba
Autor:
David G. Tew, Patrick Camilleri, Patricia Sweeney, Nigel J. Pearce, Anthony N. Shaw, Theo A. Berkhout, John W. Yates, Brian Jackson, Helen F. Boyd, Pieter H. E. Groot, Andrew Derrick Gribble
Publikováno v:
Biochemical Journal. 334:113-119
ATP citrate (pro-S)-lyase (EC 4.1.3.8), a cytosolic enzyme that generates acetyl-CoA for cholesterol and fatty acid synthesis de novo, is a potential target for hypolipidaemic intervention. Here we describe the biological effects of the inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07b90e7279f49fc3d28bbc236f1d1907
https://doi.org/10.1042/bj3340113
https://doi.org/10.1042/bj3340113
Autor:
David McNair, John W. Yates, Pieter H. E. Groot, Andrew Derrick Gribble, Brian Peter Slingsby, Mark D. Allen, Riccardo Novelli, Roland E. Dolle, C. E. Novelli, Barbara A. Saxty, Nigel J. Pearce, Virendra P. Shah, David G. Tew, Antony Nicholas Shaw
Publikováno v:
Journal of Medicinal Chemistry. 39:3569-3584
ATP-citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Inhibitors of the enzyme represent a potentially novel class of hypolipidemic agent, which are anticipated to have combined hypocholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6171a47de2d6664a5d94441efcd14bc
https://doi.org/10.1021/jm960167w
https://doi.org/10.1021/jm960167w
Autor:
Roland E. Dolle, Antony Nicholas Shaw, Andrew Derrick Gribble, John W. Yates, Virendra P. Shah, C. E. Novelli, Barbara A. Saxty, David G. Tew, Mark D. Allen, David McNair, Pieter H. E. Groot, Nigel J. Pearce, Brian Peter Slingsby, Riccardo Novelli
Publikováno v:
ChemInform. 27
ATP-citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Inhibitors of the enzyme represent a potentially novel class of hypolipidemic agent, which are anticipated to have combined hypocholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0bfd01a381ddc88b5a0b05d562b3b2e
https://doi.org/10.1002/chin.199652108
https://doi.org/10.1002/chin.199652108
Autor:
John W. Yates
John W. Yates explores the meaning and significance of the Apostle Paul's description of the divine Spirit as'life-giving'. He argues that with this designation Paul develops a tradition present in the literature of Ancient Judaism and identifies the
Autor:
David G. Tew, Virendra P. Shah, Pieter H.E. Groot, H Boyd, Robert J. Ife, John W. Yates, Antony Nicholas Shaw, R C Haltiwanger, S Bakewell, David McNair, G Okafo, S Ashman, Neil Pearce, C. E. Novelli, Andy Gribble, R. E. Dolle, Drake S. Eggleston
Publikováno v:
Journal of medicinal chemistry. 41(19)
A series of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids have been synthesized and evaluated as inhibitors of the recombinant human form of ATP-citrate lyase. The best of these have Ki's in the 200-1000 nM range. As the correspond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62217e309d18eb3cd032e1ccd00dab3f
https://pubmed.ncbi.nlm.nih.gov/9733484
https://pubmed.ncbi.nlm.nih.gov/9733484