Zobrazeno 1 - 10
of 45
pro vyhledávání: '"John W. Whitaker"'
Autor:
Rizi Ai, Teresina Laragione, Deepa Hammaker, David L. Boyle, Andre Wildberg, Keisuke Maeshima, Emanuele Palescandolo, Vinod Krishna, David Pocalyko, John W. Whitaker, Yuchen Bai, Sunil Nagpal, Kurtis E. Bachman, Richard I. Ainsworth, Mengchi Wang, Bo Ding, Percio S. Gulko, Wei Wang, Gary S. Firestein
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Fibroblast-like synoviocytes (FLS) in the intimal layer of the synovium can become invasive and destroy cartilage in patients with rheumatoid arthritis (RA). Here the authors integrate a variety of epigenomic data to map the epigenome of FLS in RA an
Externí odkaz:
https://doaj.org/article/5335c5581683468bbfffd411af6416a5
Autor:
Yun Zhu, Zhao Chen, Kai Zhang, Mengchi Wang, David Medovoy, John W. Whitaker, Bo Ding, Nan Li, Lina Zheng, Wei Wang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The human genome is highly organized, with one-dimensional chromatin states packaged into higher level three-dimensional architecture. Here, the authors present EpiTensor that can identify 3D spatial associations from 1D epigenetic information.
Externí odkaz:
https://doaj.org/article/54d65bca25564014bcd842f0e9a3acf1
Autor:
Darrell S. Rigel, John W Whitaker, Maral Skelsey, Burkhard Jansen, Michael D. Howell, Gary L. Peck
Publikováno v:
Journal of Investigative Dermatology. 142:232-234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb2a1d7165cf11549e110254fe3d5d96
https://doi.org/10.1016/j.jid.2021.06.024
https://doi.org/10.1016/j.jid.2021.06.024
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3668-3677
Histones are modified by enzymes that act in a locus, cell-type, and developmental stage-specific manner. The recruitment of enzymes to chromatin is regulated at multiple levels, including interaction with sequence-specific DNA-binding factors. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b50e8c8c0e85000b0b1654a6a14db4
https://doi.org/10.1073/pnas.1813565116
https://doi.org/10.1073/pnas.1813565116
Autor:
Alina Markova, John W. Whitaker, Rizi Ai, Alexander Pan, Stephen Dusza, Mario E. Lacouture, Arifa Chowdhury, Miguel-Angel Perales, Susan E. Prockop, Doris M. Ponce
Publikováno v:
Transplantation and Cellular Therapy. 28:S30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c999545fa2f6f6381b1ffa58d56ad363
https://doi.org/10.1016/s2666-6367(22)00194-4
https://doi.org/10.1016/s2666-6367(22)00194-4
Autor:
Chengyu Liu, Kai Zhang, Rizi Ai, Shicai Fan, John W. Whitaker, Jun Wang, Vu Ngo, Zhao Chen, Mengchi Wang, Yue Chen, Wei Wang, Lina Zheng
Publikováno v:
Nucleic Acids Research
DNA methylation is an important epigenetic mark but how its locus-specificity is decided in relation to DNA sequence is not fully understood. Here, we have analyzed 34 diverse whole-genome bisulfite sequencing datasets in human and identified 313 mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951ba2fd862afb13b9e6a44b041ab2c8
Autor:
Gary S. Firestein, Deepa Hammaker, Keisuke Maeshima, Anna-Karin H. Ekwall, David L. Boyle, John W. Whitaker, Wei Wang
Publikováno v:
Arthritis & Rheumatology. 68:2637-2645
Objective To identify nonobvious therapeutic targets for rheumatoid arthritis (RA), we performed an integrative analysis incorporating multiple "omics" data and the Encyclopedia of DNA Elements (ENCODE) database for potential regulatory regions. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf2c94e1ff450768fc08462e6aa4541
https://doi.org/10.1002/art.39746
https://doi.org/10.1002/art.39746
Autor:
David Medovoy, Wei Wang, Nan Li, Yun Zhu, Zhao Chen, Mengchi Wang, Lina Zheng, Bo Ding, John W. Whitaker, Kai Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications
The human genome is tightly packaged into chromatin whose functional output depends on both one-dimensional (1D) local chromatin states and three-dimensional (3D) genome organization. Currently, chromatin modifications and 3D genome organization are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbe554eec56b508afebaa9a242551ed
https://doaj.org/article/54d65bca25564014bcd842f0e9a3acf1
https://doaj.org/article/54d65bca25564014bcd842f0e9a3acf1
Autor:
David L. Boyle, Richard I. Ainsworth, Teresina Laragione, Vinod Krishna, Yuchen Bai, Kurtis E. Bachman, Wei Wang, Bo Ding, Emanuele Palescandolo, Rizi Ai, Pércio S. Gulko, John W. Whitaker, Keisuke Maeshima, Andre Wildberg, Mengchi Wang, Deepa Hammaker, David Pocalyko, Sunil Nagpal, Gary S. Firestein
Publikováno v:
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature communications, vol 9, iss 1
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Epigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS), including histone modifications (H3K27a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d4ab37939b3328ffb6341b8d116f5a
https://doi.org/10.1038/s41467-018-04310-9
https://doi.org/10.1038/s41467-018-04310-9
Autor:
Huaming Chen, Terrence J. Sejnowski, Joseph R. Ecker, Matthew D. Schultz, Nisha Rajagopal, Yiing Lin, Mark A. Urich, Shin Lin, John W. Whitaker, Wei Wang, Yupeng He, Siddarth Selvaraj, Manoj Hariharan, Bing Ren, Anthony D. Schmitt, Inkyung Jung, Danny Leung, Joseph R. Nery, Eran A. Mukamel
Publikováno v:
Nature
Nature, vol 523, iss 7559
Nature, vol 523, iss 7559
Summary Understanding the diversity of human tissues is fundamental to disease and requires linking genetic information, which is identical in most of an individual’s cells, with epigenetic mechanisms that could play tissue-specific roles. Surveys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9971787b35a52524b16a8e7d4ca7050c
http://europepmc.org/articles/PMC4499021
http://europepmc.org/articles/PMC4499021