Zobrazeno 1 - 10
of 14
pro vyhledávání: '"John W. Watters"'
Autor:
Tuan Nguyen, Sai Li, Jeremy T-H Chang, John W. Watters, Htet Ng, Adewola Osunsade, Yael David, Shixin Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Here the authors used single-molecule imaging and manipulation to study the mechanical effects of transcription factor Sox2 co-condensation with DNA and chromatin. They found that Sox2 condensates exert a high level of mechanical stress on DNA, but t
Externí odkaz:
https://doaj.org/article/a5fc41cecb574669a410977790cd6293
SUMMARYGenomic DNA is a crowded track where translocating motor proteins frequently collide. It remains unclear whether these collisions, generally thought to occur inadvertently, carry any physiological function. In this work, we developed a single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::940db491a97fd51afba455d2d8249006
https://doi.org/10.1101/2022.10.23.513370
https://doi.org/10.1101/2022.10.23.513370
Publikováno v:
Molecular Cell. 83:1153-1164.e4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e180c68d76ab10ee34df202560e48db9
https://doi.org/10.1016/j.molcel.2023.02.017
https://doi.org/10.1016/j.molcel.2023.02.017
Autor:
Rachel Leicher, Adewola Osunsade, Gabriella N. L. Chua, Sarah C. Faulkner, Andrew P. Latham, John W. Watters, Tuan Nguyen, Emily C. Beckwitt, Sophia Christodoulou-Rubalcava, Paul G. Young, Bin Zhang, Yael David, Shixin Liu
Publikováno v:
Nat Struct Mol Biol
The H1 linker histone family is the most abundant group of eukaryotic chromatin-binding proteins. However, their contribution to chromosome structure and function remains incompletely understood. Here we use single-molecule fluorescence and force mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13d9511e093efc8eba43aa873cd6fbc
https://europepmc.org/articles/PMC9117509/
https://europepmc.org/articles/PMC9117509/
Autor:
David A. Nicewicz, Evan W. Reynolds, Cole L. Cruz, Timothy D. Schwochert, Eric M. Brustad, John W. Watters
Publikováno v:
ChemBioChem. 21:3146-3150
A pair of 9-mesityl-10-phenyl acridinium (Mes-Acr+ ) photoredox catalysts were synthesized with an iodoacetamide handle for cysteine bioconjugation. Covalently tethering of the synthetic Mes-Acr+ cofactors with a small panel of thermostable protein s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6359ea27fdb545715a202d495542708d
https://doi.org/10.1002/cbic.202000362
https://doi.org/10.1002/cbic.202000362
Autor:
Tuan Nguyen, Sai Li, Jeremy T-H Chang, John W. Watters, Htet Ng, Adewola Osunsade, Yael David, Shixin Liu
Publikováno v:
Nature communications. 13(1)
Formation of biomolecular condensates constitutes an emerging mechanism for transcriptional regulation. Recent studies suggest that the co-condensation between transcription factors (TFs) and DNA can generate mechanical forces driving genome rearrang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19b56072e744a79346f5cfe5c7ab082
https://pubmed.ncbi.nlm.nih.gov/35810158
https://pubmed.ncbi.nlm.nih.gov/35810158
Autor:
Rachel Leicher, Adewola Osunsade, Gabriella N.L. Chua, Sarah C. Faulkner, Andrew P. Latham, John W. Watters, Tuan A. Nguyen, Emily C. Beckwitt, Sophia Christodoulou-Rubalcava, Paul G. Young, Bin Zhang, Yael David, Shixin Liu
Publikováno v:
Biophysical Journal. 121:357a-358a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d755444ac58fb09e41371464a30fb3c
https://doi.org/10.1016/j.bpj.2021.11.974
https://doi.org/10.1016/j.bpj.2021.11.974
A cytochrome P450 was engineered to selectively incorporate Ir(Me)-deuteroporphyrin IX (Ir(Me)-DPIX), in lieu of heme, in bacterial cells. Cofactor selectivity was altered by introducing mutations within the heme-binding pocket that discriminate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9e252b0850846ddfb3874e429f749c
https://europepmc.org/articles/PMC5875912/
https://europepmc.org/articles/PMC5875912/
Publikováno v:
Veterinary Surgery. 14:213-217
Urethrotomy was performed on 12 normal male dogs at the base of the os penis. The surgical site was allowed to heal by second intention in six dogs, and suture closure of the urethral mucosa, tunica albuginea, and subcuticular tissue was performed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21c7776770b85e664a88978afdc9d3f6
https://doi.org/10.1111/j.1532-950x.1985.tb00865.x
https://doi.org/10.1111/j.1532-950x.1985.tb00865.x
Publikováno v:
Veterinary Radiology. 19:60-64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebfc9a1dbee78cd5da86ac74e3b8b6d8
https://doi.org/10.1111/j.1740-8261.1978.tb01141.x
https://doi.org/10.1111/j.1740-8261.1978.tb01141.x