Zobrazeno 1 - 10
of 28
pro vyhledávání: '"John W. Trauger"'
Autor:
Rodger Pasieczny, Alice Jiang, Karen Lariosa-Willingham, Richard L. Kraus, John W. Trauger, Mary S. Turner
Publikováno v:
Journal of Neurochemistry. 94:819-827
Minocycline is neuroprotective in animal models of a number of acute CNS injuries and neurodegenerative diseases. While anti-inflammatory and anti-apoptotic effects of minocycline have been characterized, the molecular basis for the neuroprotective e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::446a32f076dbe6f9fc06211b6efa2b1c
https://doi.org/10.1111/j.1471-4159.2005.03219.x
https://doi.org/10.1111/j.1471-4159.2005.03219.x
Publikováno v:
Archives of Biochemistry and Biophysics. 405:13-20
Rho-kinase II (ROCK-II) is a serine/threonine kinase that is involved in regulation of smooth muscle contraction and has been shown to contribute to the early stages of axon formation in neurons and the regulation of the neuronal cytoskeleton. Much o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86eddb9c795ecf425de4ca7cf65c8be2
https://doi.org/10.1016/s0003-9861(02)00249-7
https://doi.org/10.1016/s0003-9861(02)00249-7
Autor:
C. Gary Marshall, Thomas A. Keating, David E. Ehmann, Christopher T. Walsh, John W. Trauger, Rahul M. Kohli
Publikováno v:
ChemBioChem. 2:99-107
A large number of therapeutically useful natural peptides areproduced nonribosomally by assembly line enzymology, involv-ing multidomain and multimodular catalysts that activate andassemble constituent amino acid monomers into oligopeptides.The pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0cf39e60f5c33a8b5dd8061c01729cf
https://doi.org/10.1002/1439-7633(20010202)2:2<99::aid-cbic99>3.0.co
https://doi.org/10.1002/1439-7633(20010202)2:2<99::aid-cbic99>3.0.co
Publikováno v:
Nature. 407:215-218
In the biosynthesis of many macrocyclic natural products by multidomain megasynthases, a carboxy-terminal thioesterase (TE) domain is involved in cyclization and product release1,2; however, it has not been determined whether TE domains can catalyse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7cd301376d27efc9e0eec4a26abc72
https://doi.org/10.1038/35025116
https://doi.org/10.1038/35025116
Autor:
Christopher T. Walsh, John W. Trauger
Publikováno v:
Proceedings of the National Academy of Sciences. 97:3112-3117
The gene cluster from Amycolotopsis orientalis responsible for biosynthesis of the vancomycin-type glycopeptide antibiotic chloroeremomycin was recently sequenced, indicating that this antibiotic derives from a seven-residue peptide synthesized by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d04c01a83ab366d2c8b2bdbeaf4fa5
https://doi.org/10.1073/pnas.97.7.3112
https://doi.org/10.1073/pnas.97.7.3112
Publikováno v:
Journal of Molecular Biology. 286:973-981
Transcription factor IIIB (TFIIIB) is composed of the TATA box binding protein (TBP) and class III gene-specific TBP-associated factors (TAFs). TFIIIB is brought to a site centered approximately 35 bp upstream from the transcription start site of tRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4e8ea78681cfb86b1c6fbfbbda99d3f
https://doi.org/10.1006/jmbi.1999.2539
https://doi.org/10.1006/jmbi.1999.2539
Publikováno v:
Angewandte Chemie. 110:1489-1492
Eine Verdopplung der Lange der Erkennungssequenz bei gleicher Grose des Liganden wird dadurch erreicht, das die Titel-Polyamide bei der Bindung an DNA ein kooperatives Haarnadel-Dimer bilden (siehe schematische Darstellung unten). Die Affinitat und d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36867c4c12443236ea31cb7ecf494e66
https://doi.org/10.1002/(sici)1521-3757(19980518)110:10<1489::aid-ange1489>3.0.co
https://doi.org/10.1002/(sici)1521-3757(19980518)110:10<1489::aid-ange1489>3.0.co
Publikováno v:
Journal of Molecular Biology. 274:439-445
The gene-specific transcription factor IIIA (TFIIIA) binds to the internal promoter element of the 5 S rRNA gene through nine zinc fingers which make specific DNA contacts. Seven of the nine TFIIIA zinc fingers participate in major groove DNA contact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7528be069961a418a7fee3ec53ae687
https://doi.org/10.1006/jmbi.1997.1411
https://doi.org/10.1006/jmbi.1997.1411
Publikováno v:
Chemistry & Biology. 3(5):369-377
Background: Three-ring polyamides containing N-methylimidazole and N-methylpyrrole amino acids bind sequence-specifically to double-helical DNA by forming side-by-side complexes in the minor groove. Simple pairing rules relate the amino-acid sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0475aaa3d0fe0f23f6b026b3742d1f00
Publikováno v:
Journal of the American Chemical Society. 118:6160-6166
The sequence-specific recognition of the minor groove of DNA by pyrrole−imidazole polyamides has been extended to 9−13 base pairs (bp). Four polyamides, ImPyPy-Py-PyPyPy-Dp, ImPyPy-G-PyPyPy-Dp, ImPyPy-β-PyPyPy-Dp, and ImPyPy-γ-PyPyPy-Dp (Im = N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae1b1b86b4626e02dc366b1a841db5f
https://doi.org/10.1021/ja960726o
https://doi.org/10.1021/ja960726o