Zobrazeno 1 - 10
of 21
pro vyhledávání: '"John W. Tomsho"'
Publikováno v:
ACS Omega, Vol 4, Iss 11, Pp 14551-14559 (2019)
Externí odkaz:
https://doaj.org/article/3d61d0c58835458b96d45eedf76b73f4
Publikováno v:
ACS Omega, Vol 4, Iss 11, Pp 14551-14559 (2019)
Drug resistance in bacteria is a serious threat, and drugs with novel modes of action are constantly needed. Fosmidomycin is a naturally occurring antibiotic that inhibits the nonmevalonate pathway via inhibition of the enzyme 1-deoxylulose-5-phospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8687d34fc60a92ed3b2a5e035a81ef67
https://doi.org/10.1021/acsomega.9b01774
https://doi.org/10.1021/acsomega.9b01774
Publikováno v:
Analytical chemistry. 90(19)
Vacuum matrix-assisted ionization (vMAI) uses select matrix compounds which when exposed to the vacuum of a mass spectrometer produce gas-phase ions from associated volatile or nonvolatile analyte without external energy input. Here, a vMAI source wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642571485986831c46ec8a8a90e0a6df
https://pubmed.ncbi.nlm.nih.gov/30130391
https://pubmed.ncbi.nlm.nih.gov/30130391
Autor:
Sarah J Burke, John W. Tomsho, James M. Gamrat, Nicholas R Sadowski, Bryan C Figula, Giulia Mancini, Rebecca C Colandrea
Publikováno v:
The Journal of organic chemistry. 83(11)
The synthesis and utility of three benzoxaborole protecting groups are reported. These protecting groups improve organic solubility and allow otherwise incompatible reactions (oxidations, substitutions, and mild reductions) to be achieved in the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5a2648a79675aefc7e60e8ef239dff
https://pubmed.ncbi.nlm.nih.gov/29724096
https://pubmed.ncbi.nlm.nih.gov/29724096
Publikováno v:
ChemInform. 47
Increased interest in boron-containing pharmaceuticals has created a need for efficient syntheses of organoboron compounds. This article describes one- and two-pot syntheses of potassium haloalkyltrifluoroborate salts, important building blocks for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37a98ddcb4f3f2e7fd6df27b14380d11
https://doi.org/10.1002/chin.201604165
https://doi.org/10.1002/chin.201604165
Autor:
Stephen J. Benkovic, John W. Tomsho
Publikováno v:
The Journal of Organic Chemistry. 77:2098-2106
In this work, the reaction between phenylboronic acid and the diol-containing, fluorescent dye Alizarin Red S (ARS) was probed. Fluorescence titrations, (11)B NMR measurements, and both pre- and steady-state kinetic experiments were used for the char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0223f0fa3e92e9a9738a63163fff5dc6
https://doi.org/10.1021/jo202250d
https://doi.org/10.1021/jo202250d
Publikováno v:
ACS Medicinal Chemistry Letters. 3:48-52
In this work, we present an investigation into the physical properties of a unique class of aromatic boronic acids, the benzoxaboroles. Using spectrophotometric methods, the ionization constants of a family of substituted benzoxaboroles are determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715bcaff714b8b7c6a019a342e318b99
https://doi.org/10.1021/ml200215j
https://doi.org/10.1021/ml200215j
Publikováno v:
Archives of Biochemistry and Biophysics. 488:140-145
Phosphorus-containing pseudopeptides, racemic at the C-terminal alpha-carbon, are potent mechanism-based inhibitors of folylpolyglutamate synthetase (FPGS). They are mimics of the tetrahedral intermediate postulated to form during FPGS-catalyzed bios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c34404e4138abfcf3b1f0c19cea901
https://doi.org/10.1016/j.abb.2009.06.017
https://doi.org/10.1016/j.abb.2009.06.017
Autor:
Kenneth C. Keiler, Lin Cheng, Bryan J. Venters, Sue Jean Hong, John W. Tomsho, Stephen J. Benkovic, Todd A. Naumann, Alexander R. Horswill
Publikováno v:
Protein Science. 16:1535-1542
A method to rapidly screen libraries of cyclic peptides in vivo for molecules with biological activity has been developed and used to isolate cyclic peptide inhibitors of the ClpXP protease. Fluorescence activated cell sorting was used in conjunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f200967e53d21cecd15890413dec213
https://doi.org/10.1110/ps.072933007
https://doi.org/10.1110/ps.072933007
Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay
Autor:
John N. Alumasa, Kenneth C. Keiler, Sarah E. Ades, Shaima Ahmed El-Mowafi, Herve Nicoloff, Elena V. Sineva, John W. Tomsho
Publikováno v:
Antimicrobial agents and chemotherapy. 59(1)
Gram-negative bacteria are formidable pathogens because their cell envelope presents an adaptable barrier to environmental and host-mediated challenges. The stress response pathway controlled by the alternative sigma factor σ E is critical for maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c14a0e025e01a9e10e9e44430ecce69
https://pubmed.ncbi.nlm.nih.gov/25331704
https://pubmed.ncbi.nlm.nih.gov/25331704