Zobrazeno 1 - 10
of 144
pro vyhledávání: '"John W. Tobias"'
Autor:
Il-Kyu Kim, Mark S. Diamond, Salina Yuan, Samantha B. Kemp, Benjamin M. Kahn, Qinglan Li, Jeffrey H. Lin, Jinyang Li, Robert J. Norgard, Stacy K. Thomas, Maria Merolle, Takeshi Katsuda, John W. Tobias, Timour Baslan, Katerina Politi, Robert H. Vonderheide, Ben Z. Stanger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Acquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses,
Externí odkaz:
https://doaj.org/article/96e408eb89f447649478a14b903b0f6a
Autor:
Richard A. Stone, John W. Tobias, Wenjie Wei, Jonathan Schug, Xia Wang, Lixin Zhang, P. Michael Iuvone, Debora L. Nickla
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The prevalence of myopia (nearsightedness) is increasing to alarming levels, but its etiology remains poorly understood. Because both laboratory and clinical findings suggest an etiologic role for circadian rhythms in myopia development, we
Externí odkaz:
https://doaj.org/article/632b8575791f42609d74fd17ad24de8b
Autor:
M. Grazia Cotticelli, Shujuan Xia, Rachel Truitt, Nicolai M. Doliba, Andrea V. Rozo, John W. Tobias, Taehee Lee, Justin Chen, Jill S. Napierala, Marek Napierala, Wenli Yang, Robert B. Wilson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/04295511604a417f96a22b6e45f7fbc4
Autor:
Thomas E. Nyul, Keely Beyries, Taylor Hojnacki, Rebecca Glynn, Kayla E. Paulosky, Anitej Gedela, Ariana Majer, Lily Altman, Kole H. Buckley, Zijie Feng, Kunfeng Sun, Zhicheng Peng, John W. Tobias, Xianxin Hua, Bryson W. Katona
Publikováno v:
Cancers, Vol 15, Iss 16, p 4126 (2023)
Background and Aims: Menin is a nuclear scaffold protein that regulates gene transcription in an oftentimes tissue-specific manner. Our previous work showed that menin is over-expressed in colorectal cancer (CRC); however, the full spectrum of menin
Externí odkaz:
https://doaj.org/article/b2f80e1a05d144e3bde7a4cfebdd116f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6716 (2023)
LC3b (Map1lc3b) plays an essential role in canonical autophagy and is one of several components of the autophagy machinery that mediates non-canonical autophagic functions. Phagosomes are often associated with lipidated LC3b to promote phagosome matu
Externí odkaz:
https://doaj.org/article/cf985765cc524683a1e8d9d89ba359bb
Autor:
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell
Externí odkaz:
https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b
Autor:
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/515147b47c8045f7a83bb33af1989d17
Autor:
Yuta Kasagi, Prasanna M. Chandramouleeswaran, Kelly A. Whelan, Koji Tanaka, Veronique Giroux, Medha Sharma, Joshua Wang, Alain J. Benitez, Maureen DeMarshall, John W. Tobias, Kathryn E. Hamilton, Gary W. Falk, Jonathan M. Spergel, Andres J. Klein-Szanto, Anil K. Rustgi, Amanda B. Muir, Hiroshi Nakagawa
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 333-352 (2018)
Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids is needed to stud
Externí odkaz:
https://doaj.org/article/21163af81d7441fbb6e128ef99587eeb
Autor:
Ting-Lin B. Yang, Qijun Chen, Jennifer T. Deng, Geetha Jagannathan, John W. Tobias, David C. Schultz, Shan Wang, Christopher J. Lengner, Anil K. Rustgi, John P. Lynch, F. Brad Johnson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Mice lacking telomerase provide a model to study pathogenesis caused by critical telomere shortening. Here, the authors provide evidence that telomere shortening causes downregulation of Wnt signalling in intestinal crypts and that defects can be par
Externí odkaz:
https://doaj.org/article/84db73bd9d44488982b5724af9d64be0
Autor:
David M. Feldser, Travis J. Yates, Michelle Cicchini, Caroline Kim-Kiselak, A. Andrea Gudiel, Charuhas Deshpande, John W. Tobias, Elizabeth L. Buza, Olivia S. Venancio, David M. Walter
Supplementary Table 3: Gene ontology analysis for genes deregulated by both Arid1a and Setd2 loss.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4fe00ed8f0169ad9244e103bd52315
https://doi.org/10.1158/0008-5472.22416824.v1
https://doi.org/10.1158/0008-5472.22416824.v1