Fusel Alcohols Regulate Translation Initiation by Inhibiting eIF2B to Reduce Ternary Complex in a Mechanism That May Involve Altering the Integrity and Dynamics of the eIF2B Body

Autor: Mark P. Ashe, Graham D. Pavitt, Paul F. G. Sims, Susan G. Campbell, Christian D. Griffiths, Peter J. Reid, Eleanor Taylor, Daniela Delneri, Richard J. Harrison, John W. Slaven

Publikováno v: Molecular Biology of the Cell 21 (2010) 13
Molecular Biology of the Cell, 21(13), 2202-2216
Molecular Biology of the Cell

This study highlights a connection between the eIF2B body and the regulation of translation initiation as a response to stress in Saccharomyces cerevisiae. Fusel alcohols are involved in signaling nitrogen scarcity to the cell and they inhibit protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef476c0ed86ad62f0e93d1de8fc13ec9
https://doi.org/10.1091/mbc.e09-11-0962

A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols

Autor: Alan B. Sachs, Mark P. Ashe, Salma Ibrahimo, John W. Slaven, Susan K. De Long

Fusel alcohols are natural products of amino acid catabolism in the yeast Saccharomyces cerevisiae that cause morphological changes similar to those seen during pseudohyphal growth. We have discovered that certain of these alcohols, including butanol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e589890c09cac4806de03aa3d29f54
https://europepmc.org/articles/PMC125737/