Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John W. Skoug"'
The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T-cell engager (BITES), Dual Variable Domain (DVD) antibodies, and fusion protei
Autor:
Robert D. Hubbard, William E. Kohlbrenner, Kevin D. Cluff, Leiming Li, Hong Yong, John W. Skoug, Xiaobin Zhao, Ji Zhou, Yemin Liu, Jingfeng Song, Yu Shen
Publikováno v:
Journal of Drug Targeting. 20:281-289
To design a clinically viable small interfering RNA (siRNA) formulation, it is essential to understand the in vivo siRNA delivery mechanism during the product development. However, majority of reported siRNA delivery studies are based on testing only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f521f53b22aa3ccb52461741e3c9df
https://doi.org/10.3109/1061186x.2011.645160
https://doi.org/10.3109/1061186x.2011.645160
Autor:
Ping Gao, K.C. Sung, Patel Mahest, T. Robert Ju, John W. Skoug, Phillip R. Nixon, Elizabeth M. Topp
Publikováno v:
International Journal of Pharmaceutics. 142:53-60
The objective of this work was to assess the effect of two formulation variables, hydroxypropylmethylcellulose (HPMC)/lactose ratio and HPMC viscosity grade, on the release of a model drug and HPMC, as well as the mechanism of drug release from HPMC-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4386cfb97f9291fb3eaaabb8e7abe9ce
https://doi.org/10.1016/0378-5173(96)04644-3
https://doi.org/10.1016/0378-5173(96)04644-3
Publikováno v:
Pharmaceutical Research. 12:965-971
Purpose. A mathematical model is described for the prediction of the relative change in drug release rate as a function of formulation composition for HPMC-based extended-release (ER) tablets of adinazolam mesylate and alprazolam.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4daf7764d03cacbf8c0ff587f41de479
https://doi.org/10.1023/a:1016246028338
https://doi.org/10.1023/a:1016246028338
Publikováno v:
Pharmaceutical Research. 12:738-745
A gradient high performance liquid chromatographic method was developed to determine degradation products of adinazolam mesylate in a sustained release tablet formulation. Sample preparations were chromatographed on a YMC-Basic column using a formate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88b10caa4c6ed22aaa672f65423dd060
https://doi.org/10.1023/a:1016219927912
https://doi.org/10.1023/a:1016219927912
Autor:
Domenick Argenti, Manuel Vincente Sanchez-Felix, Barbara M. Davit, Jack Cook, Nancy P. Barbour, Francis X. Muller, Amitava Mitra, Shoufeng Li, Alfredo García-Arieta, Vivek S. Purohit, Kerry John Hartauer, James E. Polli, John W. Skoug, Jean-Marie Geoffroy, K. Tang, Paul A. Dickinson
This summary workshop report highlights presentations and over-arching themes from an October 2011 workshop. Discussions focused on best practices in the application of biopharmaceutics in oral drug product development and evolving bioequivalence app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5eef778c08dda5a1a0d8462305a51b
https://europepmc.org/articles/PMC3385831/
https://europepmc.org/articles/PMC3385831/
Publikováno v:
Journal of Controlled Release. 27:227-245
A method based on size exclusion chromatography and differential viscometric detection was developed for the measurement of polymer concentration in dissolution samples. The method was developed to evaluate the drug release mechanism of matrix sustai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a2ee58459220e8f0c6160f938e77440
https://doi.org/10.1016/0168-3659(93)90154-w
https://doi.org/10.1016/0168-3659(93)90154-w
Publikováno v:
Pharmaceutical Research. :1482-1488
The mechanism of release from sustained-release adinazolam mesylate tablets was assessed by the Higuchi equation and by analysis of drug release profiles through 60% released using the Peppas equation. Computed values of the diffusional exponent, n,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff5a8d971bfa4b8b94ac9205d1c0eb3
https://doi.org/10.1023/a:1015834114359
https://doi.org/10.1023/a:1015834114359
Autor:
John W. Skoug
Publikováno v:
Dissolution Technologies. 1:3-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5484f20ba21888db43a2a363af1a35a7
https://doi.org/10.14227/dt010294p3
https://doi.org/10.14227/dt010294p3
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468460384
To obtain an in vitro-in vivo relationship (IVIVR), two sets of data are needed. The first set is the in vivo data, usually a pharmacokinetic metric derived from a plasma concentration profile (e.g., AUC, Cmax, % Absorbed, etc.). The second data set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e5a12b75b9743beb980c42bb1ca9618
https://doi.org/10.1007/978-1-4684-6036-0_2
https://doi.org/10.1007/978-1-4684-6036-0_2