Zobrazeno 1 - 10
of 237
pro vyhledávání: '"John W. Semple"'
Autor:
June Li, Danielle Karakas, Feng Xue, Yingyu Chen, Guangheng Zhu, Yeni H. Yucel, Sonya A. MacParland, Haibo Zhang, John W. Semple, John Freedman, Qizhen Shi, Heyu Ni
Publikováno v:
Research, Vol 6 (2023)
Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of pla
Externí odkaz:
https://doaj.org/article/d855d9b595ef481e9037018204a124a5
Autor:
Yashuan Chao, Johan Rebetz, Anna Bläckberg, Gisela Hovold, Torgny Sunnerhagen, Magnus Rasmussen, John W. Semple, Oonagh Shannon
Publikováno v:
Platelets, Vol 32, Iss 8, Pp 1092-1102 (2021)
SARS-CoV-2 has spread rapidly worldwide, causing the COVID-19 pandemic. Platelet activation and platelet-leukocyte complex formation are proposed to contribute to disease progression. Here, we report platelet and leukocyte activation during acute and
Externí odkaz:
https://doaj.org/article/265ff6c8125f484e8776b3f288ddc3b1
Autor:
Frida Palm, Axel Broman, Genevieve Marcoux, John W. Semple, Thomas L Laurell, Johan Malmström, Oonagh Shannon
Publikováno v:
Journal of Innate Immunity, Pp 1-1 (2023)
Extracellular vesicles (EVs) are derived from the membrane of platelets and released in the circulation upon activation or injury. Analogous to the parent cell, platelet derived EVs play an important role in hemostasis and immune responses by transfe
Externí odkaz:
https://doaj.org/article/fb7dc2fd5aee4bdc870b8a275b4a3844
Autor:
Drew Provan, John W. Semple
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103820- (2022)
Summary: Primary immune thrombocytopenia is an autoimmune disease associated with a reduced peripheral blood platelet count. The phenotype is variable with some patients suffering no bleeding whilst others have severe bleeding which may be fatal. Var
Externí odkaz:
https://doaj.org/article/6afc3d9a645e4413bba06c0fa63c0f8d
Publikováno v:
Platelets, Vol 31, Iss 3, Pp 399-402 (2020)
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which autoantibodies and/or autoreactive T cells destroy platelets and megakaryocytes in the spleen and bone marrow, respectively. Thrombopoietin receptor agonists (TPO-RA e.g. Romip
Externí odkaz:
https://doaj.org/article/25ef7f1e632e4ea2bf6a53b2231ecd3c
Autor:
Carlo Balduini, Kathleen Freson, Andreas Greinacher, Paolo Gresele, Thomas Kühne, Marie Scully, Tamam Bakchoul, Paul Coppo, Tadeja Dovc Drnovsek, Bertrand Godeau, Yves Gruel, A. Koneti Rao, Johanna A. Kremer Hovinga, Michael Makris, Axel Matzdorff, Andrew Mumford, Alessandro Pecci, Hana Raslova, José Rivera, Irene Roberts, Rüdiger E. Scharf, John W. Semple, Christel Van Geet
Publikováno v:
HemaSphere, Vol 5, Iss 7, p e601 (2021)
Externí odkaz:
https://doaj.org/article/8ba7f6d7312943fe8b0edeb9f8b14afc
Autor:
Martina H. Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Adrian R. Wilkie, Hans Gaus, Jazana M. Goolsby, Ross Okazaki, Brooke E. Terkovich, John W. Semple, Jonathan N. Thon, Scott P. Henry, Padmakumar Narayanan, Joseph E. Italiano Jr.
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
Antisense oligonucleotides (ASO) are DNA-based, disease-modifying drugs. Clinical trials with 2'-O-methoxyethyl (2’MOE) ASO have shown dose- and sequence-specific lowering of platelet counts according to two phenotypes. Phenotype 1 is a moderate (b
Externí odkaz:
https://doaj.org/article/ac735069e61e406db2676efc4ab4c007
Autor:
Peter A. A. Norris, George B. Segel, W. Richard Burack, Ulrich J. Sachs, Suzanne N. Lissenberg-Thunnissen, Gestur Vidarsson, Behnaz Bayat, Christine M. Cserti-Gazdewich, Jeannie Callum, Yulia Lin, Donald Branch, Rick Kapur, John W. Semple, Alan H. Lazarus
Publikováno v:
Haematologica, Vol 106, Iss 1 (2020)
Externí odkaz:
https://doaj.org/article/771986d585e448e1a0715204745ac32b
Autor:
Vivianne S. Nelson, Anne-Tess C. Jolink, Sufia N. Amini, Jaap Jan Zwaginga, Tanja Netelenbos, John W. Semple, Leendert Porcelijn, Masja de Haas, Martin R. Schipperus, Rick Kapur
Publikováno v:
Cells, Vol 10, Iss 11, p 3235 (2021)
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet cl
Externí odkaz:
https://doaj.org/article/9000ed3fbab742979f3393fa44f91677
Publikováno v:
Platelets, Vol 28, Iss 5, Pp 521-524 (2017)
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. First-line treatment includes intravenous immunoglobulin (IVIg), however, its working mechanism remains incompletely understood. We investigated sp
Externí odkaz:
https://doaj.org/article/1efcc2db19e24937873b72ae9045b163