Výsledky vyhledávání - "John W. Newland"

Role of shiga-like toxin I in bacterial enteritis: Comparison between isogenic Escherichia coli strains induced in rabbits

Autor: Joseph Fondacaro, Edgar C. Boedeker, John W. Newland, P. Gemski, Robert Sjogren, David Fritz, Roger Neill, Curtis A. Colleton, Daniel Rachmilewitz, Douglas D. Sharpnack

Publikováno v: Gastroenterology. 106:306-317

Background/Aims: Enteroadherent Escherichia coli that produce Shiga-like toxins are important causes of human disease, including enterohemorrhagic E. coli -induced colitis (EHEC). The role of Shiga-like toxins in these illnesses is unclear. The aim o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b13db8d370ec568c1c678c5c1d06ae
https://doi.org/10.1016/0016-5085(94)90587-8

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Genotypic and phenotypic characterization of an aroD deletion-attenuated Escherichia coli K12-Shigella flexneri hybrid vaccine expressing S. flexneri 2a somatic antigen

Autor: Thomas L. Hale, Samuel B. Formal, John W. Newland

Publikováno v: Vaccine. 10:766-776

The construction and characterization of EcSf2a-2, an aroD-deleted Escherichia coli-Shigella hybrid vaccine carrying chromosomal and plasmid genes from Shigella flexneri and expressing S. flexneri 2a somatic antigen in association with E. coli K12 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e330a6a4e2bc330cdd9cc4c1f34288a9
https://doi.org/10.1016/0264-410x(92)90512-i

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Construction, characterization, and animal testing of WRSd1, a Shigella dysenteriae 1 vaccine

Autor: Joan R. Butterton, Marie A. McDonough, Malabi M. Venkatesan, Vessela S. Ivanova, Thomas L. Hale, John W. Newland, Antoinette B. Hartman

Publikováno v: Infection and immunity. 70(6)

WRSd1 is a Shigella dysenteriae 1 vaccine containing deletions of the virG(icsA) gene required for intercellular spreading and a 20-kb chromosomal region encompassing the Shiga toxin genes ( stxAB ). WRSd1 was constructed from S. dysenteriae 1 strain

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https://pubmed.ncbi.nlm.nih.gov/12010984

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Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2

Autor: David N. Taylor, Genevieve Losonsky, Thomas L. Hale, Steven S. Wasserman, John W. Newland, Karen L. Kotloff, Samuel B. Formal, James P. Nataro, Myron M. Levine, Jeral C. Sadoff

Publikováno v: Vaccine. 13(5)

In previous trials, live invasive Escherichia coli-Shigella flexneri 2a hybrid vaccine candidate EcSf2a-2, administered to adult volunteers as 3 doses of ca. 2 x 10(9) colony forming units (c.f.u.) spaced over one week, induced fever and/or diarrhea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71fb8d8fe34d989bdb4869921ab8d0f
https://pubmed.ncbi.nlm.nih.gov/7639017

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Intracellular spread of Shigella flexneri associated with the kcpA locus and a 140-kilodalton protein

Autor: T Pál, Thomas L. Hale, John W. Newland, Ben D. Tall, Samuel B. Formal

Publikováno v: Infection and Immunity. 57:477-486

Escherichia coli K-12 hybrids carrying both the 220-kilobase plasmid and the purE-linked kcpA locus from Shigella flexneri expressed a 140-kilodalton (kDa) protein which was recognized by convalescent sera from monkeys infected with S. flexneri. Thes

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https://doi.org/10.1128/iai.57.2.477-486.1989

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Nucleotide sequence analysis of the structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coli

Autor: John W. Newland, Randall K. Holmes, Matthew P. Jackson, Alison D. O'Brien

Publikováno v: Microbial Pathogenesis. 2:147-153

A nucleotide sequence analysis was performed on the Shiga-like toxin I genes previously cloned from the Escherichia coli bacteriophage 933J. Two structural genes designated slt-I A and slt-I B were found to be oriented on a single transcriptional uni

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https://doi.org/10.1016/0882-4010(87)90106-9

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Nucleotide sequence analysis and comparison of the structural genes for Shiga-like toxin I and Shiga-like toxin II encoded by bacteriophages fromEscherichia coli933

Autor: Alison D. O'Brien, Randall K. Holmes, Roger Neill, John W. Newland, Matthew P. Jackson

Publikováno v: FEMS Microbiology Letters. 44:109-114

The nucleotide sequence of the Shiga-like toxin type II (SLT-II) structural genes cloned from bacteriophage 933W of the enterohemorrhagic Escherichia coli O157:H7 strain 933 was determined. This sequence was compared with the published sequence for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4936dc83f127865b927c4b6d11bd59ef
https://doi.org/10.1111/j.1574-6968.1987.tb02252.x

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Shiga and Shiga-Like Toxins: A Family of Related Cytotoxins

Autor: L. R. M. Marques, M. A. Moore, Debra L. Weinstein, Randall K. Holmes, N. A. Strockbine, Matthew P. Jackson, Alison D. O'Brien, Roger Neill, John W. Newland

Publikováno v: Molecular Basis of Viral and Microbial Pathogenesis ISBN: 9783642732164

Shiga toxin is a potent cytotoxin produced by Shigella dysenteviae 1 that is also enterotoxic for ligated rabbit ileum and paralytic and lethal for mice and rabbits (1). Shiga toxin was first described in 1903 by Conradi (2), and it is the prototype

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https://doi.org/10.1007/978-3-642-73214-0_11

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