Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John W. McGinty"'
Autor:
Tyler E. Billipp, Connie Fung, Lily M. Webeck, Derek B. Sargent, Matthew B. Gologorsky, Margaret M. McDaniel, Darshan N. Kasal, John W. McGinty, Kaitlyn A. Barrow, Lucille M. Rich, Alessio Barilli, Mark Sabat, Jason S. Debley, Richard Myers, Michael R. Howitt, Jakob von Moltke
Publikováno v:
bioRxiv
Tuft cells are solitary chemosensory epithelial cells that can sense lumenal stimuli at mucosal barriers and secrete effector molecules to regulate the physiology and immune state of their surrounding tissue. In the small intestine, tuft cells detect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a5077dec2253525a95e08a19d5a318
https://doi.org/10.1101/2023.03.17.533208
https://doi.org/10.1101/2023.03.17.533208
Autor:
Karthik Mouli, Elena Kamynina, Seth A. Peng, Becca A. Flitter, Bridget M. Mooney, Pamela Campioli, Rebecca L. Cubitt, Michael J. Shanahan, Isabella Rauch, Simon P. Früh, Oyebola O. Oyesola, James D. Lord, Marija S. Nadjsombati, Praveen Sethupathy, Madeline J Churchill, Jakob von Moltke, Shuchi Smita, Karsten Gronert, Macy K. Matheson, Duc H. Pham, Matt Kanke, Jordan L. Cahoon, Elia D. Tait Wojno, Pavithra Sundaravaradan, John W. McGinty, Lauren M. Webb
Publikováno v:
The Journal of Experimental Medicine
Type 2 cytokines promote epithelial changes that help to expel worms during intestinal helminth infection. Oyesola et al. show that prostaglandin D2 and its receptor CRTH2 are novel negative regulators of this response, dampening the Type 2 cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634e6869920806c0d6f27c6239769b1e
http://europepmc.org/articles/PMC8294949
http://europepmc.org/articles/PMC8294949
Autor:
John W. McGinty, Eddie A. James, Yi Jing, Matthew L. Bettini, Maria Bettini, Gabriele Blahnik-Fagan, Yuelin Kong
Publikováno v:
Diabetes. 69
T cells specific for post-translationally modified (PTM) islet antigens have been implicated as critical players in the development of type 1 diabetes. T cells reactive to the deamidated version of glutamic acid decarboxylase 65 (GAD65) 115-127 epito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db0983d6c7f5cd523fdf1fc4547a8e1c
https://doi.org/10.2337/db20-287-or
https://doi.org/10.2337/db20-287-or
Autor:
Gerald T. Nepom, Richard J. Notturno, I-Ting Chow, Carla J. Greenbaum, Nadia Torres-Chinn, Antonis K. Moustakas, Eddie A. James, Brian D. Evavold, George K. Papadopoulos, William W. Kwok, John W. McGinty, Elizabeth Motunrayo Kolawole, Theresa J. Gates
Publikováno v:
Science Advances
A functional epistatic interaction between susceptible HLAs provides a molecular basis for the contribution of HLA-DQ8 transdimer.
Human leukocyte antigen (HLA)–DQ8 transdimer (HLA-DQA1*0501/DQB1*0302) confers exceptionally high risk in autoim
Human leukocyte antigen (HLA)–DQ8 transdimer (HLA-DQA1*0501/DQB1*0302) confers exceptionally high risk in autoim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c4f6f34e931c48c7ae88d5cf92c680
http://europepmc.org/articles/PMC6703875
http://europepmc.org/articles/PMC6703875
Autor:
Jakob von Moltke, John W. McGinty
Publikováno v:
Curr Opin Immunol
The varied list of agonists that activate innate lymphoid cells (ILCs) continues to grow, but whether and how these signals interact is not well defined, especially in vivo. ILC subsets share master transcription factors, chromatin landscapes, and ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e08ff2ea63e75b6c251529051167ab
https://pubmed.ncbi.nlm.nih.gov/31830683
https://pubmed.ncbi.nlm.nih.gov/31830683
Autor:
Marija S. Nadjsombati, Ichiro Matsumoto, Jakob von Moltke, Nora A. Barrett, Hung-An Ting, Danish M. Khan, John W. McGinty, Tyler E. Billipp, Hong-Erh Liang
Publikováno v:
Immunity. 52:528-541.e7
Helminths, allergens, and certain protists induce type 2 immune responses, but the underlying mechanisms of immune activation remain poorly understood. In the small intestine, chemosensing by epithelial tuft cells results in the activation of group 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66146dbef9cd6c299d155f2eaee5b317
https://doi.org/10.1016/j.immuni.2020.02.005
https://doi.org/10.1016/j.immuni.2020.02.005
Autor:
John W. McGinty, Saltanat Ualiyeva, Daniel F. Dwyer, Nora A. Barrett, Eri Yoshimoto, Lora G. Bankova, K. Frank Austen, Jakob von Moltke, Yoshihide Kanaoka, Hannah Raff
Publikováno v:
Science Immunology. 3
Respiratory epithelial cells (EpCs) orchestrate airway mucosal inflammation in response to diverse environmental stimuli, but how distinct EpC programs are regulated remains poorly understood. Here, we report that inhalation of aeroallergens leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6759bcaea34e58cb3065e639d4931168
https://doi.org/10.1126/sciimmunol.aat9453
https://doi.org/10.1126/sciimmunol.aat9453
Autor:
Joshua L. Pollack, Miranda R. Lyons-Cohen, G. A. Nagana Gowda, Richard M. Locksley, John W. McGinty, Jakob von Moltke, Daniel Raftery, David J. Erle, Marija S. Nadjsombati
SummaryInitiation of immune responses requires innate immune sensing, but immune detection of the helminths, protists, and allergens that stimulate type 2 immunity remains poorly understood. In the small intestine, type 2 immune responses are regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e401803a1b8155eec3ac73365be91e
Autor:
Noah W Beck, David M. Harlan, Sally C. Kent, I-Ting Chow, Jon D. Piganelli, Eddie A. James, Rita Bottino, William W. Kwok, Alvin C. Powers, Megan E DeNicola, Meghan L. Marré, John W. McGinty, Carla J. Greenbaum
In spite of tolerance mechanisms, some individuals develop T-cell–mediated autoimmunity. Posttranslational modifications that increase the affinity of epitope presentation and/or recognition represent one means through which self-tolerance mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1600d09b0730c151fd4072bb35764bf3
https://europepmc.org/articles/PMC6014552/
https://europepmc.org/articles/PMC6014552/
Autor:
Eddie A, James, Joana R F, Abreu, John W, McGinty, Jared M, Odegard, Yvonne E, Fillié, Claire N, Hocter, Slobodan, Culina, Kristin, Ladell, David A, Price, Aimon, Alkanani, Marynette, Rihanek, Lisa, Fitzgerald-Miller, Ania, Skowera, Cate, Speake, Peter, Gottlieb, Howard W, Davidson, F Susan, Wong, Bart, Roep, Roberto, Mallone
Publikováno v:
Diabetologia. 61(3)
Validated biomarkers are needed to monitor the effects of immune intervention in individuals with type 1 diabetes. Despite their importance, few options exist for monitoring antigen-specific T cells. Previous reports described a combinatorial approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17cc2c815c8cecbb460f585597e01cff
https://pubmed.ncbi.nlm.nih.gov/29196783
https://pubmed.ncbi.nlm.nih.gov/29196783