Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John W. Koontz"'
Autor:
John W. Koontz, Ramin Alemzadeh, Melissa K. Standridge, Naima Moustaid-Moussa, Michael B. Zemel
Publikováno v:
The FASEB Journal. 14:455-460
We have previously reported that attenuation of hyperinsulinemia by diazoxide (DZ), an inhibitor of glucose-mediated insulin secretion, increased insulin sensitivity and reduced body weight in obese Zucker rats. These findings prompted us to investig
Autor:
John W. Koontz, Li Pan
Publikováno v:
Archives of Biochemistry and Biophysics. 316:886-892
We have established a system in which we observe a synergistic interaction between insulin and glucocorticoids, This includes chimeric genes constructed to contain synthetic glucocorticoid-responsive elements, 5′ of the HSV thymidine kinase promote
Publikováno v:
European journal of endocrinology. 146(6)
OBJECTIVES: Chronic attenuation of hyperinsulinemia by diazoxide (DZ), an inhibitor of glucose-mediated insulin secretion, improved insulin sensitivity and glucose tolerance and caused down-regulation of lipid metabolizing enzymes in adipose tissue a
Publikováno v:
Archives of biochemistry and biophysics. 298(2)
Insulin-mediated regulation of glucocorticoid-induced expression of the liver-specific gene tyrosine amino-transferase was studied in a clone of the Reuber rat hepatoma cells. Insulin inhibited dexamethasone-induced chloramphenicol acetyltransferase
Autor:
Douglas Carmichael, John W. Koontz
Publikováno v:
Biochemical and biophysical research communications. 187(2)
This study used transient transfection analysis to determine the DNA regions which mediate basal and insulin-sensitive transcription from the gene encoding tyrosine aminotransferase (TAT; EC 2.6.1.5). Basal expression requires at least parts of two r
Publikováno v:
Journal of leukocyte biology. 52(3)
Both 3:5′ cyclic adenosine monophosphate (cAMP) and 3′:5′ cyclic guanosine monophosphate (cGMP) stimulated colony-stimulating factor 1 (CSF-1)–dependent colony formation by murine two-signal–dependent progenitors without influencing colony
Publikováno v:
Annals of the New York Academy of Sciences. 349:195-209
Autor:
John W. Koontz
Publikováno v:
Molecular and Cellular Biochemistry. 58:139-146
Insulin is able to stimulate a growth response in a variety of different cell types. However, the role of the insulin receptor in mediating this response is not clear. Indeed, it has been reported that the ability of insulin to stimulate a growth res
Publikováno v:
Archives of Biochemistry and Biophysics. 266:343-350
Reuber H35 rat hepatoma cells respond to insulin or to tumor promoting phorbol esters with an increase in ornithine decarboxylase enzyme activity. This occurs in a time-and dose-dependent manner with both types of agonist. We report here that the inc
Autor:
John W. Koontz, Patrick S. Moore
Publikováno v:
Molecular Endocrinology. 3:1724-1732
Tyrosine aminotransferase (TAT) is a liver-specific enzyme whose activity is subject to positive regulation by several agents including insulin and agonists that increase the intracellular concentration of cAMP. To further characterize the mechanism