Výsledky vyhledávání - "John W. Harrell"

Reduced basal macrovascular and microvascular cerebral blood flow in young adults with metabolic syndrome: potential mechanisms

Autor: Katrina J. Carter, Aaron T. Ward, J. Mikhail Kellawan, John W. Harrell, Garrett L. Peltonen, Grant S. Roberts, Awni Al-Subu, Scott A. Hagen, Ronald C. Serlin, Marlowe Eldridge, Oliver Wieben, William G. Schrage

Publikováno v: Journal of Applied Physiology.

90 million Americans suffer metabolic syndrome (MetSyn), increasing risk of diabetes and poor brain outcomes including neuropathology linked to lower cerebral blood flow (CBF)-predominantly in anterior regions. We tested the hypothesis total and regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e1528b43ab749406defaa5f3874e67d
https://doi.org/10.1152/japplphysiol.00688.2022

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Preserved β-adrenergic-mediated vasodilation in skeletal muscle of young adults with obesity despite shifts in cyclooxygenase and nitric oxide synthase

Autor: Katrina J. Carter, Jaqueline K. Limberg, Rebecca E. Johansson, John W Harrell, Joshua J. Sebranek, Garrett L. Peltonen, Benjamin J. Walker, Marlowe W. Eldridge, William G. Schrage, J. Mikhail Kellawan

Publikováno v: Am J Physiol Heart Circ Physiol

Central adiposity is associated with greater sympathetic support of blood pressure. β-adrenergic receptors (β-AR) buffer sympathetically mediated vasoconstriction and β-AR-mediated vasodilation is attenuated in preclinical models of obesity. With

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8e09b1715c554d28626853121bf47f
https://doi.org/10.1152/ajpheart.00449.2021

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Differential contribution of cyclooxygenase to basal cerebral blood flow and hypoxic cerebral vasodilation

Autor: John W. Harrell, Garrett L. Peltonen, Oliver Wieben, J. Mikhail Kellawan, William G. Schrage, Alejandro Roldán-Alzate

Publikováno v: Am J Physiol Regul Integr Comp Physiol

Cyclooxygenase (COX) is proposed to regulate cerebral blood flow (CBF); however, accurate regional contributions of COX are relatively unknown at baseline and particularly during hypoxia. We hypothesized that COX contributes to both basal and hypoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c26107805f6a524d9f6ac632597e0c
https://doi.org/10.1152/ajpregu.00132.2019

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Cerebral blood flow regulation in women across menstrual phase: differential contribution of cyclooxygenase to basal, hypoxic, and hypercapnic vascular tone

Autor: Kaylie M. LaPlante, Meghan K. Crain, William G. Schrage, Garrett L. Peltonen, John W. Harrell, Benjamin P. Aleckson

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 311:R222-R231

In healthy young women, basal cerebral blood flow (CBF) and cerebrovascular reactivity may change across the menstrual cycle, but mechanisms remain untested. When compared with the early follicular phase of the menstrual cycle, we hypothesized women

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f919e5f5a3b80a72795ce3866910bbbb
https://doi.org/10.1152/ajpregu.00106.2016

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Regional hypoxic cerebral vasodilation facilitated by diameter changes primarily in anterior versus posterior circulation

Autor: J. Mikhail Kellawan, Oliver Wieben, John W. Harrell, Alejandro Roldán-Alzate, William G. Schrage

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 37:2025-2034

The inability to quantify cerebral blood flow and changes in macrocirculation cross-sectional area in all brain regions impedes robust insight into hypoxic cerebral blood flow control. We applied four-dimensional flow magnetic resonance imaging to qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4805154595bbc499bdcd4b7d5461eeb
https://doi.org/10.1177/0271678x16659497

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β-Adrenergic-mediated vasodilation in young men and women: cyclooxygenase restrains nitric oxide synthase

Autor: Joshua J. Sebranek, Jacqueline K. Limberg, Marlowe W. Eldridge, William G. Schrage, J. Mikhail Kellawan, Garrett L. Peltonen, Rebecca E. Johansson, John W. Harrell

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 310:H756-H764

We tested the hypothesis that women exhibit greater vasodilator responses to β-adrenoceptor stimulation compared with men. We further hypothesized women exhibit a greater contribution of nitric oxide synthase and cyclooxygenase to β-adrenergic-medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8d0687b5d172d7a2ded9e2db372283
https://doi.org/10.1152/ajpheart.00886.2015

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Reactive oxygen species and cyclooxygenase products explain the majority of hypoxic cerebral vasodilation in healthy humans

Autor: William G. Schrage, John W. Harrell, Garrett L. Peltonen

Publikováno v: Acta physiologica (Oxford, England). 226(4)

AIM The role of reactive oxygen species (ROS) in human cerebral blood flow (CBF) during hypoxia is largely unknown. Additionally, it is unknown whether ROS interact with cyclooxygenase-derived signals during hypoxia to increase CBF. We hypothesized R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa4feb9ec39388aa872992071d0f2bf
https://pubmed.ncbi.nlm.nih.gov/31033206

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