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of 138
pro vyhledávání: '"John W. Finnie"'
Autor:
John W. Finnie
Publikováno v:
Veterinary Sciences, Vol 11, Iss 1, p 2 (2023)
Clostridium perfringens type D epsilon toxin (ETX) causes severe retinal microvascular endothelial injury in the rat. The resulting blood–retinal barrier (BRB) breakdown leads to increased vascular permeability, which was detected immunohistochemic
Externí odkaz:
https://doaj.org/article/1c084b43405f49ed9b399bc10be85d5d
Pathology and Pathogenesis of Brain Lesions Produced by Clostridium perfringens Type D Epsilon Toxin
Autor:
John W. Finnie, Francisco A. Uzal
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9050 (2022)
Clostridium perfringens type D epsilon toxin (ETX) produces severe, and frequently fatal, neurologic disease in ruminant livestock. The disorder is of worldwide distribution and, although vaccination has reduced its prevalence, ETX still causes subst
Externí odkaz:
https://doaj.org/article/8d3fc95495d24231829d9018f054521e
Autor:
John W. Finnie, Peter C. Blumbergs
Publikováno v:
Child's Nervous System. 38:2317-2324
Background Abusive head trauma (AHT), previously known as the shaken baby syndrome, is a severe and potentially fatal form of traumatic brain injury in infant children who have been shaken, and sometimes also sustained an additional head impact. The
Autor:
Michael Worthington, Jim Manavis, John F. Beltrame, T. Surman, John W. Finnie, John M. Abrahams, Karen J. Reynolds, Dermot O'Rourke, James Edwards
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-10 (2021)
Journal of Cardiothoracic Surgery
Journal of Cardiothoracic Surgery
Background Although aortic root and ascending aortic aneurysms are treated the same, they differ in embryological development and pathological processes. This study examines the microscopic structural differences between aortic root and ascending aor
Publikováno v:
Journal of Comparative Pathology. 187:17-26
Summary In order to better differentiate ante-mortem lesions from post-mortem retinal autolysis, the temporal sequence of post-mortem changes was studied in a well-controlled mouse model. Mice were of the same strain, age and sex, and were held at a
Autor:
Mathew Smith, John W. Finnie, Nathan Rout-Pitt, Nigel Farrow, Lewis Vaughan, Patricia Cmielewski, Tim Kuchel, Martin Donnelley, Emma Knight, Chris Christou, David Parsons, Juliette M. K. M. Delhove
Publikováno v:
Human Gene Therapy. 32:806-816
Gene therapy continues to be a promising contender for the treatment of cystic fibrosis (CF) airway disease. We have previously demonstrated that airway conditioning with lysophosphatidylcholine (L...
Autor:
Dennis H. Lau, John W. Finnie, Muayad Alasady, Krupesh P. Patel, Rajiv Mahajan, John P. M. Wood, Jonathan M. Kalman, Prashanthan Sanders, Nicholas J. Shipp, Anthony G. Brooks, Jim Manavis, Chrishan S. Samuel
Publikováno v:
JACC: Clinical Electrophysiology. 7:630-641
Objectives This study sought to evaluate the effect of weight loss on the atrial substrate for atrial fibrillation (AF). Background Whether weight loss can reverse the atrial substrate of ...
Autor:
Benjamin G Spencer, John W. Finnie
Publikováno v:
Journal of Comparative Pathology. 181:86-91
It is now increasingly recognized that endoplasmic reticulum (ER) stress, which is caused by the accumulation of overproduced or misfolded proteins in this organelle, contributes to the pathogenesis of a diverse range of human diseases. ER stress ini
Autor:
Purba Nag, Meaghan Wall, Andrew Burgess, Debottam Sinha, John W. Finnie, Kum Kum Khanna, Murugan Kalimutho, Devathri Nanayakkara, Veronique A. J. Smits, Goutham Subramanian, Prahlad V. Raninga, Pascal H.G. Duijf, Amanda L. Bain
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-16 (2020)
Communications Biology
Communications Biology
High expression of centrosomal protein CEP55 has been correlated with clinico-pathological parameters across multiple human cancers. Despite significant in vitro studies and association of aberrantly overexpressed CEP55 with worse prognosis, its caus
Autor:
Victoria Sherwood, Kim M. Hemsley, Timothy R. Kuchel, Adam B. O’Connell, A. Jennifer Morton, John W. Finnie, Daniel Neumann, Sunthara Rajan Perumal
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 79:1084-1092
We created an excitotoxic striatal lesion model of Huntington disease (HD) in sheep, using the N-methyl-d-aspartate receptor agonist, quinolinic acid (QA). Sixteen sheep received a bolus infusion of QA (75 µL, 180 mM) or saline, first into the left