Zobrazeno 1 - 10
of 128
pro vyhledávání: '"John W. Drake"'
Autor:
Libertad García-Villada, John W. Drake
Publikováno v:
Open Biology, Vol 3, Iss 6 (2013)
Understanding virus evolution is key for improving ways to counteract virus-borne diseases. Results from comparative analyses have previously suggested a trade-off between fecundity and lifespan for viruses that infect the bacterium Escherichia coli
Externí odkaz:
https://doaj.org/article/5448c5fe5e2a4d5bbc418ea185c66e2f
Autor:
John W. Drake
Publikováno v:
Genetics, Evolution and Radiation ISBN: 9783319488370
Nikolai Timofeeff-Ressovsky understood well the need for both explicit theory and quantitation in biology. His adventures with Karl Zimmer and Max Delbruck and the somewhat romantic portrayal of those ideas by Erwin Schrodinger contributed notably to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee9b21cc792e72074296faa25f10a676
https://doi.org/10.1007/978-3-319-48838-7_7
https://doi.org/10.1007/978-3-319-48838-7_7
Autor:
John W. Drake
Publikováno v:
DNA Repair. 11:703-713
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d0413471e915ece99180f4967481b0b
https://doi.org/10.1016/j.dnarep.2012.01.009
https://doi.org/10.1016/j.dnarep.2012.01.009
Publikováno v:
Journal of Molecular Biology. 404:778-793
Phage RB69 B-family DNA polymerase is responsible for the overall high fidelity of RB69 DNA synthesis. Fidelity is compromised when conserved Tyr567, one of the residues that form the nascent polymerase base-pair binding pocket, is replaced by alanin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4261acb19f7ffa2cba2beae634988ae
https://doi.org/10.1016/j.jmb.2010.09.058
https://doi.org/10.1016/j.jmb.2010.09.058
Publikováno v:
Genetics. 176:697-702
Spontaneous mutations in the orotate:phosphoribosyl transferase (pyrE2) gene of the halophilic archaeon Haloferax volcanii were selected by 5-fluoroorotic acid plus uracil at a rate of ∼2 × 10−8/cell division in fluctuation and null-fraction tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03977b81c5698917a98235aec4df3ca3
https://doi.org/10.1534/genetics.106.069666
https://doi.org/10.1534/genetics.106.069666
Autor:
John W. Drake
Publikováno v:
Genetics. 173:1-8
THIS story starts with one of those unanticipated turning points that mark the lives of most of us. Around 1960 I was working at the University of Illinois at Urbana using Newcastle disease virus (NDV), a tractable animal virus that infects chickens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdc415a27a12357cdda0ca200b70b8f
https://doi.org/10.1093/genetics/173.1.1
https://doi.org/10.1093/genetics/173.1.1
Publikováno v:
Biochemistry. 45:2211-2220
DNA polymerase is the central component of replicases that are responsible for faithfully copying DNA. Despite the fact that all four dNTPs are potential substrates, replicative DNA polymerases are able to limit the incorporation of mismatched bases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effa53032c4a9b36d0d07869f8eb9122
https://doi.org/10.1021/bi052099y
https://doi.org/10.1021/bi052099y
Autor:
John W. Drake
Publikováno v:
G3: Genes|Genomes|Genetics
Until recently, the two predominant ways to estimate mutation rates were the specific-locus method and the mutation-accumulation (Bateman-Mukai) method. Both involve seeding a number of parallel lines from a small, genetically uniform population, gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62ad8b48754d9b4586f71ec262f446c
https://doi.org/10.1534/g3.111.001842
https://doi.org/10.1534/g3.111.001842
Autor:
José M. Malpica, John W. Drake, Clara I Obies, I M Moreno, Aurora Fraile, Fernando García-Arenal
Publikováno v:
Genetics. 162:1505-1511
Estimates of spontaneous mutation rates for RNA viruses are few and uncertain, most notably due to their dependence on tiny mutation reporter sequences that may not well represent the whole genome. We report here an estimate of the spontaneous mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cabb4606028fd076fc7a7e3c10620c0
https://doi.org/10.1093/genetics/162.4.1505
https://doi.org/10.1093/genetics/162.4.1505