Zobrazeno 1 - 10
of 45
pro vyhledávání: '"John W. Downie"'
Publikováno v:
Brain Research. 1222:149-155
Surgical microscopy and electrophysiological techniques were used to describe in the adult male rat the peripheral distribution of the sensory branch of the pudendal nerve (SBPdn) and its sensory and somatomotor axonal components. Gross and histologi
Autor:
John W. Downie, Juan Zhou, Julie L. Jordan, Timothy D.G. Lee, Susan Elizabeth Henderson, Clive M. Elson, Agis Kydonieus
Publikováno v:
Urology. 70:1014-1018
Interstitial cystitis is a chronic, debilitating disease of the bladder. Treatments using intravesicular inoculation of long-chain polysaccharide formulations, such as hyaluronic acid or anti-inflammatory agents, have been used to some effect. The ob
Autor:
John W. Downie, Yolanda Cruz
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 290:R1436-R1445
The aims of the present study were to determine in female rats whether abdominal muscle discharges during normal voiding and to describe the effect of bladder irritation on this visceromotor activity. The sensory pathway of this reflex was also deter
Autor:
John W. Downie, Yolanda Cruz
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 289:R1307-R1318
In the present study we examined the possibility that striated muscle activity may underlie sexually dimorphic micturition in rats. Micturition dynamics, the gross anatomy of the external urethral sphincter, and the participation of the striated peri
Autor:
John W. Downie, S. Matsuura
Publikováno v:
Neurourology and Urodynamics. 19:87-99
It is well known that urethane is a suitable anesthetic for acute studies and has been extensively recommended for investigations related to micturition physiology. This is mainly because of the capability of urethane anesthesia to spare reflex mictu
Publikováno v:
Brain Research. 819:108-119
The micturition reflex pathway is a supraspinal pathway. Anatomical tracing evidence is compatible with an involvement of the periaqueductal gray (PAG) in the ascending limb of this reflex. We tested the involvement of the PAG in receiving urinary tr
Autor:
John W. Downie
Publikováno v:
Current Opinion in Urology. 3:280-283
Publikováno v:
Journal of Urology. 149:1156-1164
Autonomous wave activity occurs in the decentralized bladder and may contribute to upper tract damage and incontinence. In order to clarify the poorly understood pathophysiology and neuropharmacology of autonomous waves, cats were prepared with L7-S3
Publikováno v:
Neurourology and Urodynamics. 11:509-517
We have comprehensively investigated 10 patients with lower motor neuron (LMN) lesions (mean duration of lesions: 14 years) who were managed with intermittent catheterization. All patients (9 males and 1 female) underwent complete neurologic examinat
Publikováno v:
Journal of Urology. 144:1022-1028
We investigated the contribution of mechanical and sympathetic neural factors to proximal urethral sphincter dysfunction in the cat after chronic sacral rhizotomy. Concomitant vesicostomy prevented a decrease in the urethral pressure profile measured