Zobrazeno 1 - 10
of 30
pro vyhledávání: '"John W. Allis"'
Autor:
Guangyu Zhao, John W. Allis
Publikováno v:
Chemico-Biological Interactions. 140:137-153
We report quantitative estimates of the parameters for metabolism of bromodichloromethane (BDCM) by recombinant preparations of hepatic cytochrome P450s (CYPs) from rat and human. Earlier work identified CYP2E1, CYP2B1/2 and CYP1A2 as activating enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d6194a2cedb33eb11223b57b9a1d05
https://doi.org/10.1016/s0009-2797(02)00022-4
https://doi.org/10.1016/s0009-2797(02)00022-4
Publikováno v:
Journal of Biochemical Toxicology. 7:257-264
The acute hepatotoxicity and response of hepatic cytochrome P450 to treatment with the three isomers of dichlorobenzene (DCB) have been investigated. The objectives were to estimate the onset of toxicity and to further elucidate the role of cytochrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3e6c2f27d0bdda03b111b357044a0c
https://doi.org/10.1002/jbt.2570070409
https://doi.org/10.1002/jbt.2570070409
Publikováno v:
Fundamental and Applied Toxicology. 17:186-196
The immunotoxicity, hepatotoxicity, and nephrotoxicity of subacute exposure to carbon tetrachloride (CCl 4 ) were evaluated in young adult (8–9 weeks old) male Fischer 344 rats dosed by gavage with CCl 4 for 10 consecutive days at 0, 5, 10, 20 or 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f973c86fcc03c3262a6e2e260dc35e65
https://doi.org/10.1016/0272-0590(91)90250-8
https://doi.org/10.1016/0272-0590(91)90250-8
Publikováno v:
Toxicological Sciences. 17:186-196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bc694cf38b46883babebec66fad053d
https://doi.org/10.1093/toxsci/17.1.186
https://doi.org/10.1093/toxsci/17.1.186
Publikováno v:
Fundamental and Applied Toxicology. 15:558-570
To determine the course of hepatic recovery from subchronic oral administration of carbon tetrachloride (CCl 4 ), male F-344 rats were gavaged with 0, 20, or 40 mg CCl 4 /kg, 5 days/week, for 12 weeks. Exposure to CCl 4 caused dosage-dependent increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::140f79c13d732b887e0570269d05caca
https://doi.org/10.1016/0272-0590(90)90041-h
https://doi.org/10.1016/0272-0590(90)90041-h
Publikováno v:
Toxicological Sciences. 15:558-570
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c1823573247f24207f93dfd5af31bc7
https://doi.org/10.1093/toxsci/15.3.558
https://doi.org/10.1093/toxsci/15.3.558
Autor:
Guangyu Zhao, John W. Allis
Publikováno v:
Chemico-biological interactions. 140(2)
The kinetic constants for the metabolism of bromodichloromethane (BDCM) by three cytochrome P450 (CYP) isoenzymes have been measured in human liver microsomes. The three CYP isoenzymes, CYP2E1, CYP1A2 and CYP3A4, have been identified previously as im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e1bff610944c30e1f0bab5c85518cf
https://pubmed.ncbi.nlm.nih.gov/12076522
https://pubmed.ncbi.nlm.nih.gov/12076522
Publikováno v:
Toxicology. 176(1-2)
Bromodichloromethane (BDCM) is a drinking water disinfectant by-product that has been implicated in liver, kidney and intestinal cancers in rodents and in intestinal tumors and low birth weight effects in humans. BDCM is also hepatotoxic and requires
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d399c9f5b1be271f2e55edf34b69b404
https://pubmed.ncbi.nlm.nih.gov/12062927
https://pubmed.ncbi.nlm.nih.gov/12062927
Publikováno v:
Toxicology. 161(1-2)
Several cytochrome P450 (CYP) isoenzymes may be involved in the metabolism of bromo-dichloromethane (BDCM), a drinking water disinfection byproduct. After 4-h inhalation exposures of male F344 rats to BDCM between 100 and 3200 p.p.m., hepatic microso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44817549773a66b5117b628cc8489039
https://pubmed.ncbi.nlm.nih.gov/11295256
https://pubmed.ncbi.nlm.nih.gov/11295256
Autor:
Jane Ellen Simmons, John W. Allis, Barbara L. Brown, Dennis E. House, Anthony McDonald, Gary E. Hatch
Publikováno v:
Toxicology. 112(2)
Evidence to explain the enhanced hepatotoxicity of carbon tetrachloride (CCl4) following methanol exposure by inhalation is presented. Hepatic microsomes prepared from male F344 rats exposed to methanol at concentrations up to 10,000 ppm showed incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec28889c14df0fd4547560d79a6d006
https://pubmed.ncbi.nlm.nih.gov/8814342
https://pubmed.ncbi.nlm.nih.gov/8814342