Zobrazeno 1 - 10
of 156
pro vyhledávání: '"John W Schrader"'
Autor:
Annette Ehrhardt, Bin Wang, Andrew C Yung, Yanni Wang, Piotr Kozlowski, Cornelis van Breemen, John W Schrader
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141493 (2015)
Here we show that male, but not female mice lacking expression of the GTPase M-Ras developed urinary retention with distention of the bladder that exacerbated with age but occurred in the absence of obvious anatomical outlet obstruction. There were c
Externí odkaz:
https://doaj.org/article/b853b308fb4d460ca00e655e754a7a7d
Autor:
Rachid El Fatimy, Sandra Tremblay, Alain Y Dury, Samuel Solomon, Paul De Koninck, John W Schrader, Edouard W Khandjian
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39338 (2012)
Fragile X syndrome is caused by the absence of the Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein. FMRP is associated with messenger RiboNucleoParticles (mRNPs) present in polyribosomes and its absence in neurons leads to alterat
Externí odkaz:
https://doaj.org/article/59f98efe0a234313bc0095744bc6a714
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49891 (2012)
Human granulocyte macrophage colony-stimulating factor (hGM-CSF) is a haematopoietic growth factor and proinflammatory cytokine. Recombinant hGM-CSF is important not only as a research tool but also as a biotherapeutic. However, rhGM-CSF expressed in
Externí odkaz:
https://doaj.org/article/5ff53c4936584c77ae5447cad0801445
Autor:
Rajinder S. Hundal, Baljinder S. Salh, John W. Schrader, Antonio Gómez-Muñoz, Vincent Duronio, Urs P. Steinbrecher
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 9, Pp 1483-1491 (2001)
Oxidized LDL (oxLDL) is known to induce endothelial adhesion molecule and monocyte chemoattractant protein 1 expression and this is thought to be involved in monocyte recruitment into atherosclerotic lesions. oxLDL has also been found to induce macro
Externí odkaz:
https://doaj.org/article/6a9cb0db0fd342dc9e06adce93f43375
Autor:
Emil F. Pai, Steve Bryson, Urmi Dhagat, Michael W. Parker, Christy A. Thomson, Sophie E. Broughton, John W. Schrader, Angel F. Lopez, Emma F Barry, Barbara J. McClure, Tracy L. Nero, Timothy R. Hercus, Karen S. Cheung Tung Shing
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that can stimulate a variety of cells, but its overexpression leads to excessive production and activation of granulocytes and macrophages with many pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb334120b8a5a8cb3d8e56fdc630869
https://europepmc.org/articles/PMC6204844/
https://europepmc.org/articles/PMC6204844/
Autor:
Mike Ploski, John W. Schrader
Restricted dorsiflexion (DF) at the ankle joint can cause acute and chronic injuries at the ankle and knee. Myofascial release and instrument-assisted soft tissue mobilization (IASTM) techniques have been used to increase range of motion (ROM); howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576035772844011134274cdcfae4ba64
https://europepmc.org/articles/PMC6138267/
https://europepmc.org/articles/PMC6138267/
Autor:
Gary R. McLean, John W. Schrader
Recombinant monoclonal antibodies (Ab's) have widespread application as research tools, diagnostic reagents and as biotherapeutics. Whilst studying the cellular molecular switch protein m-ras, a recombinant monoclonal antibody to m-ras was generated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f77a588a9acbc70c6cf0cca41b7b32
https://repository.londonmet.ac.uk/1279/1/Schrader&McLean_JMR2017.pdf
https://repository.londonmet.ac.uk/1279/1/Schrader&McLean_JMR2017.pdf
Autor:
Gary P. Anderson, Thomas K. Waddell, Melanie Olson, Timothy R. Hercus, Tracy L. Nero, John W. Schrader, Yanni Wang, Michael W. Parker, Lenka Allan, John A. Hamilton, Christy A. Thomson, Angel L. Lopez, Amanda L Turner, Linda M. Jackson
Publikováno v:
Proceedings of the National Academy of Sciences. 110:7832-7837
The origin of pathogenic autoantibodies remains unknown. Idiopathic pulmonary alveolar proteinosis is caused by autoantibodies against granulocyte–macrophage colony-stimulating factor (GM-CSF). We generated 19 monoclonal autoantibodies against GM-C
Publikováno v:
The Journal of Immunology. 186:2291-2298
The human Ab response to many common pathogens is oligoclonal, with restricted usage of Ig V-genes. Intriguingly, the IGVK3-11 and IGVH3-30 V-genes are repeatedly paired in protective Abs against the 23F polysaccharide of Streptococcus pneumoniae, as
Publikováno v:
Differentiation. 77:386-394
The lens of the eye is derived from the non-neural ectoderm situated next to the optic vesicle. Fibroblast growth factor (FGF) signals play a major role at various stages of vertebrate lens development ranging from induction and proliferation to diff