Zobrazeno 1 - 10
of 55
pro vyhledávání: '"John W Pepper"'
Autor:
Trinh Nguyen, John W Pepper, Cu Nguyen, Yu Fan, Ying Hu, Qingrong Chen, Chunhua Yan, Daoud Meerzaman
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Background: Acute myeloid leukemia (AML) is a clinically heterogeneous group of cancers. While some patients respond well to chemotherapy, we describe here a subgroup with distinct molecular features that has very poor prognosis under chemotherapy. T
Externí odkaz:
https://doaj.org/article/0dde888cec5a4d998fafb7f8e2b89330
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 12, p e250 (2007)
Cell differentiation in multicellular organisms has the obvious function during development of creating new cell types. However, in long-lived organisms with extensive cell turnover, cell differentiation often continues after new cell types are no lo
Externí odkaz:
https://doaj.org/article/e92bc3900cc9476091d166f2981968c2
The canonical route from normal tissue to cancer occurs through sequential acquisition of somatic mutations. Many studies have constructed a linear genetic model for tumorigenesis using the genetic alterations associated with samples at different sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8de7917bc90542ecfccf05d69f70f87
https://doi.org/10.1158/1940-6207.c.6544851
https://doi.org/10.1158/1940-6207.c.6544851
Supplementary Materials from Accurate Reconstruction of the Temporal Order of Mutations in Neoplastic Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34311d4023bff7c1cf5661b563e1169
https://doi.org/10.1158/1940-6207.22525671
https://doi.org/10.1158/1940-6207.22525671
Publikováno v:
Evolution, Medicine, and Public Health. 2019:9-16
Background and objectives Several major risk factors for cancer involve vascular oversupply of energy to affected tissues. These include obesity, diabetes and chronic inflammation. Here, we propose a potential mechanistic explanation for the associat
Autor:
Ying Hu, Trinh Nguyen, John W Pepper, Daoud Meerzaman, Chunhua Yan, Yu Fan, Qing-Rong Chen, Cu Nguyen
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics, Vol 12 (2021)
Background: Acute myeloid leukemia (AML) is a clinically heterogeneous group of cancers. While some patients respond well to chemotherapy, we describe here a subgroup with distinct molecular features that has very poor prognosis under chemotherapy. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8aabe87a106f8245e91a13f3c444cc4
https://doi.org/10.21203/rs.3.rs-138491/v1
https://doi.org/10.21203/rs.3.rs-138491/v1
Autor:
John W. Pepper
Publikováno v:
Applied Computational Intelligence and Soft Computing, Vol 2010 (2010)
Evolutionary algorithms face a fundamental trade-off between exploration and exploitation. Rapid performance improvement tends to be accompanied by a rapid loss of diversity from the population of potential solutions, causing premature convergence on
Externí odkaz:
https://doaj.org/article/a074442bacee4832a9465e971b7e72f9
Publikováno v:
Cold Spring Harbor perspectives in medicine. 7(2)
Evolution by natural selection is the conceptual foundation for nearly every branch of biology and increasingly also for biomedicine and medical research. In cancer biology, evolution explains how populations of cells in tumors change over time. It i
Autor:
John W. Pepper
Publikováno v:
Evolution, Medicine, and Public Health. 2014:65-68
Drug-resistant bacteria are a huge and growing threat to public health. A solution exists in theory, but had not yet been put to a practical test. The accompanying paper by Ross-Gillespie et al., the theory is put to a test and performs successfully.
Autor:
Nadarajen A. Vydelingum, John W. Pepper, John K. Gohagan, Barbara K. Dunn, Richard M. Fagerstrom
Publikováno v:
Journal of Evolutionary Medicine. 2:1-8
Unsatisfactory progress in cancer medicine and prevention calls for new research approaches. Research can broaden its view of cancer to include not only specific molecular elements, but also the process that explains their origin and dynamics. This p