Zobrazeno 1 - 10
of 14
pro vyhledávání: '"John W M Creemers"'
Autor:
Jeroen Declercq, Bas Brouwers, Vincent P E G Pruniau, Pieter Stijnen, Geoffroy de Faudeur, Krizia Tuand, Sandra Meulemans, Lutgarde Serneels, Anica Schraenen, Frans Schuit, John W M Creemers
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135502 (2015)
The Nestin-Cre driver mouse line has mild hypopituitarism, reduced body weight, a metabolic phenotype and reduced anxiety. Although several causes have been suggested, a comprehensive explanation is still lacking. In this study we examined the molecu
Externí odkaz:
https://doaj.org/article/d0d11b366fd64bd8bb23929f2e9f5f42
Autor:
Kim Nuytens, Krizia Tuand, Quili Fu, Pieter Stijnen, Vincent Pruniau, Sandra Meulemans, Hugo Vankelecom, John W M Creemers
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109598 (2014)
Two knockout mouse models for the autism candidate gene Neurobeachin (Nbea) have been generated independently. Although both models have similar phenotypes, one striking difference is the dwarf phenotype observed in the heterozygous configuration of
Externí odkaz:
https://doaj.org/article/14e437cd04c04930a8433c315d040a30
Autor:
Omar Al Rifai, Delia Susan-Resiga, Rachid Essalmani, John W. M. Creemers, Nabil G. Seidah, Mathieu Ferron
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Fibroblast growth factor 23 (FGF23) is a hormone secreted from fully differentiated osteoblasts and osteocytes that inhibits phosphate reabsorption by kidney proximal tubules. The full-length (i.e., intact) protein mediates FGF23 endocrine functions,
Externí odkaz:
https://doaj.org/article/6fa941e1ee3f49689b09a891ad4c3f82
Autor:
Yang Yu, Xia Lei, Hui Jiang, Zhiqiang Li, John W. M. Creemers, Ming Zhang, Shucun Qin, Weijun Jin, Xian‐Cheng Jiang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 9 (2018)
BackgroundPhospholipid transfer protein (PLTP) is one of the major modulators of lipoprotein metabolism and atherosclerosis development; however, little is known about the regulation of PLTP. The effect of hepatic prodomain of furin (profurin) expres
Externí odkaz:
https://doaj.org/article/bec16fea4432418ca533a9e2fc4361c3
Autor:
Jean Descarpentrie, Marcos J. Araúzo-Bravo, Zongsheng He, Alexia François, Álvaro González, Patricia Garcia-Gallastegi, Iker Badiola, Serge Evrard, Simon Pernot, John W. M. Creemers, Abdel-Majid Khatib
Publikováno v:
Addi. Archivo Digital para la Docencia y la Investigación
instname
Cancers; Volume 14; Issue 5; Pages: 1195
instname
Cancers; Volume 14; Issue 5; Pages: 1195
Proprotein convertases or PCs are known to regulate the malignant phenotype of colon cancer cells by different mechanisms, but their effects on cancer stem cells (CSCs) have been less widely investigated. Here, we report that PCs expression is altere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b739c3688101b7f8ce79a7ceb98f00ff
http://hdl.handle.net/10810/55918
http://hdl.handle.net/10810/55918
Publikováno v:
Oncogene. 41(9)
Furin is the first discovered proprotein convertase member and is present in almost all mammalian cells. Therefore, by regulating the maturation of a wide range of proproteins, Furin expression and/or activity is involved in various physiological and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba20e5c9027640c71ba4640613319bb0
https://pubmed.ncbi.nlm.nih.gov/34997216
https://pubmed.ncbi.nlm.nih.gov/34997216
Autor:
Bas, Brouwers, Ilaria, Coppola, Katlijn, Vints, Bastian, Dislich, Nathalie, Jouvet, Leentje, Van Lommel, Charlotte, Segers, Natalia V, Gounko, Lieven, Thorrez, Frans, Schuit, Stefan F, Lichtenthaler, Jennifer L, Estall, Jeroen, Declercq, Bruno, Ramos-Molina, John W M, Creemers
Publikováno v:
Diabetes. 70(2)
FURIN is a proprotein convertase (PC) responsible for proteolytic activation of a wide array of precursor proteins within the secretory pathway. It maps to the PRC1 locus, a type 2 diabetes susceptibility locus, but its specific role in pancreatic β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b283cbeb315bf72cadde606864dcf59
https://pubmed.ncbi.nlm.nih.gov/33277337
https://pubmed.ncbi.nlm.nih.gov/33277337
Autor:
Dennis, Löffler, Susanne, Behrendt, John W M, Creemers, Jürgen, Klammt, Gabriela, Aust, Juraj, Stanik, Wieland, Kiess, Peter, Kovacs, Antje, Körner
Publikováno v:
Molecular Metabolism
Objective Variants in Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) may be causative for obesity as suggested by monogenic cases and association studies. Here we assessed the functional relevance in experimental studies and the clinical relev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d24e095d23f7da2f8ef793195ac2f68e
https://pubmed.ncbi.nlm.nih.gov/28271036
https://pubmed.ncbi.nlm.nih.gov/28271036
Autor:
Pieter, Stijnen, Krizia, Tuand, Tibor V, Varga, Paul W, Franks, Bert, Aertgeerts, John W M, Creemers
Publikováno v:
American Journal of Epidemiology. 181:733-734
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a035fe5ca7476a9395681a04e19653ca
https://doi.org/10.1093/aje/kwv061
https://doi.org/10.1093/aje/kwv061