Zobrazeno 1 - 9
of 9
pro vyhledávání: '"John W Lippert"'
Autor:
John W. Lippert III
Publikováno v:
ARKIVOC, Vol 2005, Iss 14, Pp 87-95 (2005)
Externí odkaz:
https://doaj.org/article/0bd235c599e04855bb87a4552bb2acb7
Autor:
John W Lippert
Publikováno v:
Journal of Analytical & Pharmaceutical Research. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3242e76eef52bb10304335bcb8f120d0
https://doi.org/10.15406/japlr.2016.03.00047
https://doi.org/10.15406/japlr.2016.03.00047
Autor:
Benson L. Nguyen, John W. Lippert, Kevin G. Pinney, Savannah Aguirre, Mary Lynn Trawick, Ernest Hamel, Rajendra P. Tanpure, Tracy E. Strecker, David J. Chaplin, Bronwyn G. Siim, Suman Sharma, George R. Pettit
Publikováno v:
Journal of Natural Products. 74:1568-1574
The natural products combretastatin A-4 (CA4) and combretastatin A-1 (CA1) are potent cancer vascular disrupting agents (VDAs) and inhibitors of tubulin assembly (IC50 = 1–2 μM). The phosphorylated prodrugs CA4P and CA1P are undergoing human clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05444a2a08940e00c56dfe3591e2c18c
https://doi.org/10.1021/np200104t
https://doi.org/10.1021/np200104t
Autor:
Ping Chen, Yingyan Chang, John W. Lippert, Yi Wang, Stephen H. Steffke, Christopher M. Manley, Keith D. Barnes, Guixing Wang, Robert M. Lewis, Nicholas J. Mayhew, Yuh-Lin A. Yang
Publikováno v:
Synthetic Communications. 41:67-72
A convergent synthesis of indoprofen via a Buchwald coupling approach is reported. Using this methodology, indoprofen and a set of analogs of indoprofen were readily prepared.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5b271c8acb6341853e142918bb26e8f
https://doi.org/10.1080/00397910903531813
https://doi.org/10.1080/00397910903531813
Autor:
Mike C. Bibby, Steve D. Shnyder, David J. Swaine, George R. Pettit, Ian G. Kirwan, Patricia A. Cooper, Paul M. Loadman, D. Alan Anthoney, John W. Lippert
Publikováno v:
Clinical Cancer Research. 10:1446-1453
Purpose: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130a3a301a376e9bd5a3d53f8dacb56c
https://doi.org/10.1158/1078-0432.ccr-0518-03
https://doi.org/10.1158/1078-0432.ccr-0518-03
Publikováno v:
Journal of Natural Products. 64:883-891
The cyclic octapeptide phakellistatin 11 (1), a constituent of The Federated States of Micronesia (Chuuk) marine sponge Phakellia sp., was synthesized using solid-phase techniques. An initial solution-phase synthesis proved to be inadequate owing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aff5efbae05765684250b15e2784eb7
https://doi.org/10.1021/np0100441
https://doi.org/10.1021/np0100441
Publikováno v:
The Journal of Organic Chemistry. 65:7438-7444
In an attempt to develop biologically active compounds from the inactive trans isomer (3a) of stilbene 1a, after asymmetric dihydroxylation to optically pure (R,R)-diol 8 the unexpected racemic diphenylacetaldehyde (9) was generated via a Pinacol rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22a04815daf95272826df97199dd2c8e
https://doi.org/10.1021/jo000705j
https://doi.org/10.1021/jo000705j
Publikováno v:
Journal of Natural Products. 63:969-974
The synthetic (E)-isomer (3b) of natural combretastatin A-1 (1a) isolated from the African bushwillow Combretum caffrum was the focus of chiral hydroxylation (Sharpless) reactions as part of a structure-activity relationship study. The resulting (R,R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2fac384b7b159b2d9edebb49eb96cb
https://doi.org/10.1021/np0000623
https://doi.org/10.1021/np0000623
Autor:
John W. Lippert
Publikováno v:
ChemInform. 42
Title compounds (III) and (V) are synthesized starting from isoindolinones (I) or (IV), resp.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b0cd3fb58adc8cee97e6736b22005e
https://doi.org/10.1002/chin.201129106
https://doi.org/10.1002/chin.201129106