Zobrazeno 1 - 10 of 17 pro vyhledávání: '"John W Hooper"'
1
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci
Autor: Peter L Szego, Helene Fournier, Jean-Michel Vidal, Bruno Paquin, Susanna Nikolaus, Walter Edward Bradley, Sophie Debrus, Hilary Clark, Paul Van Eerdewegh, Stefan Schreiber, René J. A. Paulussen, René Allard, Quynh Nguyen-Huu, Nathalie Laplante, Gunnar Jacobs, Pascal Croteau, Philip Rosenstiel, Tim Keith, Andre Franke, Randall D. Little, Jonathan Segal, Andreas Ruether, John W. Hooper, Abdelmajid Belouchi, John Verner Raelson
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 104(37)
Genome-wide association (GWA) studies offer a powerful unbiased method for the identification of multiple susceptibility genes for complex diseases. Here we report the results of a GWA study for Crohn's disease (CD) using family trios from the Quebec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd1341323260b282a2818d95c032e54
https://pubmed.ncbi.nlm.nih.gov/17804789
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3
Application issues in bioanalytical method validation, sample analysis and data reporting
Autor: Darioush Dadgar, John W. Hooper, K Gallicano, M. Gerry Choc, Pamela E. Burnett
Publikováno v: Journal of pharmaceutical and biomedical analysis. 13(2)
Although some degree of consensus has been reached concerning the requirements for acceptable method validation, the procedures used to establish them vary significantly between laboratories. Also, issues arising from application of these requirement
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e03b5ea1fbb52657152ef75cb414386
https://pubmed.ncbi.nlm.nih.gov/7766728
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5
The chemistry of fungi. Part LXIX. A new synthesis of the grisane system: X-ray crystallographic examination of (±)-methyl 5,7-di-bromo-2′α,5′α-epoxy-4-methoxy-3-oxogrisane-6′β-carboxylate
Autor: Frank C. Marsh, George Ferguson, Alan D. Borthwick, Jeffrey S. Millership, Mortaza Ahbab, W. Basil Whalley, John W. Hooper
Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1369-1376
Addition of furan to methyl 4-(2,6-dimethoxyphenyl)-4-oxobut-2-ynoate (4; R = CO2Me) followed by hydrogenation of the adduct gave methyl 3-(2,6-dimethoxybenzoyl)-7-oxabicyclo[2.2.1]hept-2-ene-2-carboxylate (6; R = Me). This was demethylated to the co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6670b322f775acabf8f7ce75828f0886
https://doi.org/10.1039/p19760001369
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6
Approaches to the synthesis of triterpenoids. IV. The ABC + E ring approach to the pentacyclic triterpene skeleton. Synthesis of a pentacyclic compound suitable for triterpene synthesis
Autor: John W. Hooper, Richard Pike, John W. ApSimon, Carol P. Huber, Satyanand Badripersaud, Michael L. Post, George Birnbaum
Publikováno v: Canadian Journal of Chemistry. 56:2139-2149
Studies on the ABC + E ring construction of the pentacyclic triterpene skeleton are described. Acid-catalysed cyclisation of the mixture of diastereoisomers 11 led to preferential cyclisation of one isomer to 10-methoxy-2,2,4aβ,6aβ, 12bβ -pentamet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bdf298afba25a0cec1ac840c27b3307
https://doi.org/10.1139/v78-350
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10
Fecal blood loss during isoxicam and piroxicam administration for 28 days
Autor: Andrew Darke, William S Martin, John W Hooper, Pedro Araujo, June A. Anslow
Publikováno v: Clinical pharmacology and therapeutics. 38(5)
After an 11-day baseline period, groups of eight healthy men received isoxicam, 200 mg once a day, or piroxicam, 20 mg once a day, for 28 days. Fecal blood loss (FBL) was quantitated by the 51Cr-labeled erythrocyte method. FBLs for both isoxicam and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3b0482b2fc1a0f5b4d679bf219fc2e
https://pubmed.ncbi.nlm.nih.gov/3876907
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