Zobrazeno 1 - 10
of 421
pro vyhledávání: '"John W Holloway"'
Autor:
Raquel Granell, John A Curtin, Sadia Haider, Negusse Tadesse Kitaba, Sara A Mathie, Lisa G Gregory, Laura L Yates, Mauro Tutino, Jenny Hankinson, Mauro Perretti, Judith M Vonk, Hasan S Arshad, Paul Cullinan, Sara Fontanella, Graham C Roberts, Gerard H Koppelman, Angela Simpson, Steve W Turner, Clare S Murray, Clare M Lloyd, John W Holloway, Adnan Custovic, on behalf of UNICORN and Breathing Together investigators
Publikováno v:
eLife, Vol 12 (2023)
Background: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of ‘doctor-diagnosed asthma’, thereby diluting genetic signals by not considering asth
Externí odkaz:
https://doaj.org/article/ef3714c583a24ddeb37692801c1faf88
Autor:
Lucy M Kimbley, Rachel Parker, Maaike Sybil Jongen, John W Holloway, Emily J Swindle, Matthew JJ Rose-Zerilli
Publikováno v:
BioTechniques, Vol 71, Iss 1, Pp 387-391 (2021)
Single-cell RNA sequencing (scRNA-seq) of the bronchial epithelium enables examination of cellular subtypes and their responses to viral infections. Here, an optimized method for the isolation of virally infected primary bronchial epithelial cells us
Externí odkaz:
https://doaj.org/article/414344b6eb0145d0816cdde2bd71dad1
Autor:
Brogan Ashley, Claire Simner, Antigoni Manousopoulou, Carl Jenkinson, Felicity Hey, Jennifer M Frost, Faisal I Rezwan, Cory H White, Emma M Lofthouse, Emily Hyde, Laura DF Cooke, Sheila Barton, Pamela Mahon, Elizabeth M Curtis, Rebecca J Moon, Sarah R Crozier, Hazel M Inskip, Keith M Godfrey, John W Holloway, Cyrus Cooper, Kerry S Jones, Rohan M Lewis, Martin Hewison, Spiros DD Garbis, Miguel R Branco, Nicholas C Harvey, Jane K Cleal
Publikováno v:
eLife, Vol 11 (2022)
Pregnancy 25-hydroxyvitamin D [25(OH)D] concentrations are associated with maternal and fetal health outcomes. Using physiological human placental perfusion and villous explants, we investigate the role of the placenta in regulating the relationships
Externí odkaz:
https://doaj.org/article/1a91c1a9eb944011801afd9ea0ec61b3
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226256 (2019)
Previous work has shown that proteins that have the potential to be vaccine candidates can be predicted from features derived from their amino acid sequences. In this work, we make an empirical comparison across various machine learning classifiers o
Externí odkaz:
https://doaj.org/article/7627e3199af44110a90a8b2275e929ce
Autor:
Htoo A. Wai, Eliska Svobodova, Natalia Romero Herrera, Andrew G. L. Douglas, John W. Holloway, Francisco E. Baralle, Marco Baralle, Diana Baralle
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 8, Pp 1816-1825 (2024)
Abstract Effective translation of rare disease diagnosis knowledge into therapeutic applications is achievable within a reasonable timeframe; where mutations are amenable to current antisense oligonucleotide technology. In our study, we identified fi
Externí odkaz:
https://doaj.org/article/68cbfaef62044777968f0b7d27f4a829
Autor:
Yu Jiang, Hongmei Zhang, Su Chen, Susan Ewart, John W. Holloway, Hasan Arshad, Wilfried Karmaus
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Early patterning of DNA methylation (DNAm) may play an important role in later disease development. To better understand intergenerational epigenetic inheritance, we investigated the correlation between DNAm in blood in mother-newborn and in
Externí odkaz:
https://doaj.org/article/15fb91d8f61a4e0a96f39f3af99d3474
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 20, Iss 1, Pp 1-7 (2024)
Abstract Background Associations between psoriasis and allergic diseases (asthma, rhinitis, and eczema) in children have been reported in a limited number of studies, and the association between psoriasis and multimorbidity (co-occurrence) of allergi
Externí odkaz:
https://doaj.org/article/108e8d0b32f344b9b1e574f1aed3c95d
Autor:
Grissel Faura Tellez, Brigitte W M Willemse, Uilke Brouwer, Susan Nijboer-Brinksma, Karl Vandepoele, Jacobien A Noordhoek, Irene Heijink, Maaike de Vries, Natalie P Smithers, Dirkje S Postma, Wim Timens, Laura Wiffen, Frans van Roy, John W Holloway, Peter M Lackie, Martijn C Nawijn, Gerard H Koppelman
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163967 (2016)
The asthma gene PCDH1 encodes Protocadherin-1, a putative adhesion molecule of unknown function expressed in the airway epithelium. Here, we characterize the localization, differential expression, homotypic adhesion specificity and function of PCDH1
Externí odkaz:
https://doaj.org/article/ef0770c4af6a47bb9bd673678b5912d4
Autor:
Chinedu Nwokoro, Hitesh Pandya, Stephen Turner, Sandra Eldridge, Christopher J Griffiths, Tom Vulliamy, David Price, Marek Sanak, John W Holloway, Rossa Brugha, Lee Koh, Iain Dickson, Clare Rutterford, Jonathan Grigg
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 2, Iss 6 (2015)
Background: The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALO
Externí odkaz:
https://doaj.org/article/e389b15af83d434d9203485d3db93a46
Autor:
Su Chen, Miranda Johs, Wilfried Karmaus, John W. Holloway, Parnian Kheirkhah Rahimabad, Jaclyn M. Goodrich, Karen E. Peterson, Dana C. Dolinoy, S. Hasan Arshad, Susan Ewart
Publikováno v:
Epigenetics Communications, Vol 4, Iss 1, Pp 1-15 (2024)
Abstract Background Pregnancy and childbirth have been connected to modified risk of a wide variety of conditions in later life, including neurodegenerative disorders and cancers. The presence, extent, and direction of the effect that childbearing st
Externí odkaz:
https://doaj.org/article/914093971bb54d6a84acfa549241ec5b