Zobrazeno 1 - 10
of 35
pro vyhledávání: '"John W George"'
Publikováno v:
Biochemical and Biophysical Research Communications. 294:225-230
Idiosyncratic drug-induced hepatitis may depend upon many factors including a balance between pro- and anti-inflammatory mediator production levels. Using a guinea pig model of liver injury induced by bioactivation of the anesthetic drug, halothane,
Autor:
John W. George, Yasuhiro Masubuchi, Hamid R. Amouzadeh, Jackie L. Martin, Lance R. Pohl, Mohammed Bourdi, Anjali G. Shah, Timothy P. Reilly
Publikováno v:
Hepatology. 35:289-298
Mechanistic study of idiosyncratic drug-induced hepatitis (DIH) continues to be a challenging problem because of the lack of animal models. The inability to produce this type of hepatotoxicity in animals, and its relative rarity in humans, may be lin
Autor:
John W. George, W. Robert Batsell
Publikováno v:
Physiology & Behavior. 60:1463-1467
In single-element taste-aversion learning, retention interval effects are seen if taste aversions are paradoxically weak when they are tested 1 day after conditioning than when they are tested 3 or more days after conditioning. One explanation of thi
Publikováno v:
Chemical Research in Toxicology. 8:993-996
Diclofenac is a nonsteroidal anti-inflammatory drug that has been implicated in several cases of severe hepatotoxicity. Our previous study showed that diclofenac metabolites bound covalently and selectively to rat liver plasma membrane proteins with
Autor:
John W. George
Publikováno v:
Progress in Inorganic Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1577cdcd581283373fbe4cce02fccef
https://doi.org/10.1002/9780470166031.ch2
https://doi.org/10.1002/9780470166031.ch2
Publikováno v:
Inorganic Syntheses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28fed58da76b810df6ed6c9c00a4244f
https://doi.org/10.1002/9780470132395.ch42
https://doi.org/10.1002/9780470132395.ch42
Publikováno v:
Inorganic Syntheses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a5deb091a31e4d24c6ae9b0194bd4fc
https://doi.org/10.1002/9780470132364.ch47
https://doi.org/10.1002/9780470132364.ch47
Autor:
Mary Louise M Graf, Yasuhiro Masubuchi, Lance R Pohl, John W George, Timothy P Reilly, Mohammed Bourdi
Publikováno v:
Biochemical and biophysical research communications. 304(1)
Recent experimental data suggest that the idiosyncratic nature of drug-induced liver disease (DILD) may be due in part to a deficiency of one or more hepatoprotective factors. In this study we have investigated whether interleukin (IL)-6 may also be
Autor:
Lance R. Pohl, Mohammed Bourdi, John W. George, Timothy P. Reilly, John N. Brady, Changqing Ju, Michael F. Radonovich
Publikováno v:
Chemical research in toxicology. 15(12)
Hepatic injury induced by various toxic agents, including acetaminophen (APAP), has been attributed, in part, to the production of proinflammatory cytokines and other mediators by resident Kupffer cells within the liver. However, recent evidence from