Zobrazeno 1 - 10
of 18
pro vyhledávání: '"John W, Hinds"'
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272771 (2022)
MYC is one of the most dysregulated oncogenes and is thought to be fundamental to tumor formation and/or maintenance in many cancer types. This dominant pro-tumor activity makes MYC an attractive target for cancer therapy. However, MYC is a transcrip
Externí odkaz:
https://doaj.org/article/ca75accf74d641108228b7a91f836076
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225784 (2019)
Our primary goal is to therapeutically target the oncogenic transcription factor MYC to stop tumor growth and cancer progression. Here, we report aspects of the biophysical states of the MYC protein and its interaction with one of the best-characteri
Externí odkaz:
https://doaj.org/article/26a7772084ca417296973f55f6a1d8aa
Identification of Let-7f-5p as a novel biomarker of recurrence in non-muscle invasive bladder cancer
Autor:
Margaret R. Karagas, Jason R. Pettus, John W Hinds, David A. Armstrong, Angeline S. Andrew, Carmen J. Marsit, John D. Seigne, Kevin Shee, Todd W. Miller, Alan R. Schned
Publikováno v:
Cancer Biomarkers. 29:101-110
BACKGROUND: Among patients diagnosed with non-muscle invasive bladder cancer (NMIBC), 30% to 70% experience recurrences within 6 to 12 years of diagnosis. The need to screen for these events every 3 to 6 months and ultimately annually by cystoscopy m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4aca96dcdac42634d501440e867983
https://doi.org/10.3233/cbm-191322
https://doi.org/10.3233/cbm-191322
Autor:
Periannan Kuppusamy, Jesse M. Mast, Maciej M. Kmiec, M. Lakshmi Kuppusamy, John W Hinds, Tamás Kálai, Dan Tse, Balázs Bognár, Katherine Axelrod
Publikováno v:
Cell Biochemistry and Biophysics. 78:191-202
Pancreatic adenocarcinoma is an aggressive cancer with poor clinical prognosis and limited therapeutic options. There is a significant lack of effective, safe, and targeted therapies for successful treatment of pancreatic cancer. In this report, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96b06d08923b11e397145c8770fe360d
https://doi.org/10.1007/s12013-020-00919-0
https://doi.org/10.1007/s12013-020-00919-0
Publikováno v:
Oncotarget
Mechanism-based targeted therapies have exhibited remarkable success in treating otherwise untreatable or unresectable cancers. Novel targeted therapies that correct dysregulated transcriptional programs in cancer are an unmet medical need. The trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a02c8254f8feeec4f18bea348042ec
https://pubmed.ncbi.nlm.nih.gov/34676047
https://pubmed.ncbi.nlm.nih.gov/34676047
Autor:
Jesse M, Mast, John W, Hinds, Dan, Tse, Katherine, Axelrod, M Lakshmi, Kuppusamy, Maciej M, Kmiec, Balázs, Bognár, Tamás, Kálai, Periannan, Kuppusamy
Publikováno v:
Cell biochemistry and biophysics. 78(2)
Pancreatic adenocarcinoma is an aggressive cancer with poor clinical prognosis and limited therapeutic options. There is a significant lack of effective, safe, and targeted therapies for successful treatment of pancreatic cancer. In this report, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e1b787034480f118c4685fed29ace9a
https://pubmed.ncbi.nlm.nih.gov/32449075
https://pubmed.ncbi.nlm.nih.gov/32449075
Autor:
Todd W. Miller, Chao Cheng, Wei Yang, Claudia Lanari, Eugene Demidenko, Frederick S. Varn, Arminja N. Kettenbach, Todd R. Golub, Philip Owens, K Patel, Anthony C. Faber, John W Hinds, Kevin Shee, Riley A. Hampsch, Ravid Straussman, Nicole P. Jenkins
Publikováno v:
Cancer Research. 78:PD4-08
Despite the clinical success of anti-estrogen therapies, phosphatidylinositol 3-kinase inhibitors (PI3Ki), and mechanistic target of rapamycin complex I inhibitors (mTORC1i) for the treatment of patients with ER+ breast cancer, disease recurrence and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b106aefe19bbc48436488af9443cc899
https://doi.org/10.1158/1538-7445.sabcs17-pd4-08
https://doi.org/10.1158/1538-7445.sabcs17-pd4-08
Autor:
Jenny A Rudnick, Lisa M Arendt, Ina Klebba, John W Hinds, Vandana Iyer, Piyush B Gupta, Stephen P Naber, Charlotte Kuperwasser
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24605 (2011)
Fibroblasts are important in orchestrating various functions necessary for maintaining normal tissue homeostasis as well as promoting malignant tumor growth. Significant evidence indicates that fibroblasts are functionally heterogeneous with respect
Externí odkaz:
https://doaj.org/article/8c770b64fc1f420da2cf9d1615a89c98
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0225784 (2019)
PLoS ONE, Vol 14, Iss 12, p e0225784 (2019)
Our primary goal is to therapeutically target the oncogenic transcription factor MYC to stop tumor growth and cancer progression. Here, we report aspects of the biophysical states of the MYC protein and its interaction with one of the best-characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e855eef48442bd80643eeb3dc80603
http://europepmc.org/articles/PMC6886782
http://europepmc.org/articles/PMC6886782
Autor:
Kishan Patel, Ravid Straussman, Chao Cheng, Anthony C. Faber, Nicole P. Jenkins, Wei Yang, Arminja N. Kettenbach, Eugene Demidenko, Nicole A. Traphagen, Kevin Shee, Frederick S. Varn, Todd R. Golub, John W Hinds, Philip Owens, Riley A. Hampsch, Todd W. Miller
Publikováno v:
The Journal of Experimental Medicine
Tumor microenvironment (TME) cytokine screening revealed FGF2 as a clinically relevant mechanism of resistance to anti-estrogens, mTORC1 inhibition, and PI3K inhibition in ER+ breast cancer. Shee et al. highlight an underdeveloped aspect of precision
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e8a38af83baa37af767135050dcea3
https://pubmed.ncbi.nlm.nih.gov/29436393
https://pubmed.ncbi.nlm.nih.gov/29436393