Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John W, Glod"'
Autor:
Maran Ilanchezhian, Diana Grace Varghese, John W. Glod, Karlyne M. Reilly, Brigitte C. Widemann, Yves Pommier, Rosandra N. Kaplan, Jaydira Del Rivero
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy of the adrenal gland with an unfavorable prognosis. It is rare in the pediatric population, with an incidence of 0.2-0.3 patients per million in patients under 20 years old. It is primaril
Externí odkaz:
https://doaj.org/article/c2b0dfd5f57441c2b815a691d120ab2b
Autor:
Christian Okafor, Julie Hogan, Margarita Raygada, Barbara J. Thomas, Srivandana Akshintala, John W. Glod, Jaydira Del Rivero
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor that accounts for 2-4% of all thyroid cancers. All inherited MTC and approximately 50% of sporadic cases are driven by mutations in the REarranged during Transfection (RET) proto-oncoge
Externí odkaz:
https://doaj.org/article/4fa88b3f6e264294930a622dd17b53fc
Publikováno v:
Current Opinion in Pediatrics. 35:63-74
Autor:
Brigitte C. Widemann, Jack F. Shern, John W. Glod, Paul S. Meltzer, Maria J. Merino, Frank M. Balis, Elizabeth Fox, Oxana Kapustina, Steven G. Waguespack, Maya Lodish, Seth M. Steinberg, Eva Dombi, Claudia Derse-Anthony, Haiyan Lei, Yuelin Zhu, Srivandana Akshintala, Ira L. Kraft
Legends for all included Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::401e3632a772a57ba85735bffe03f137
https://doi.org/10.1158/1078-0432.22464179
https://doi.org/10.1158/1078-0432.22464179
Autor:
Brigitte C. Widemann, Jack F. Shern, John W. Glod, Paul S. Meltzer, Maria J. Merino, Frank M. Balis, Elizabeth Fox, Oxana Kapustina, Steven G. Waguespack, Maya Lodish, Seth M. Steinberg, Eva Dombi, Claudia Derse-Anthony, Haiyan Lei, Yuelin Zhu, Srivandana Akshintala, Ira L. Kraft
Heat map of cell cycle gene expression. Gene expression was normalized and compared between the primary MTC, metastasis one, and metastasis two lesions from the whole transcriptome RNA-seq data. Purple indicates lower and yellow indicates higher expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6248f3a4f6a5680d83c0d84ae52748
https://doi.org/10.1158/1078-0432.22464182
https://doi.org/10.1158/1078-0432.22464182
Autor:
Brigitte C. Widemann, Jack F. Shern, John W. Glod, Paul S. Meltzer, Maria J. Merino, Frank M. Balis, Elizabeth Fox, Oxana Kapustina, Steven G. Waguespack, Maya Lodish, Seth M. Steinberg, Eva Dombi, Claudia Derse-Anthony, Haiyan Lei, Yuelin Zhu, Srivandana Akshintala, Ira L. Kraft
Weight-for-age and height-for-age growth curves. Male patient weights (A), heights (B) and female patient weights (C), and heights (D) were monitored during the follow up period. Patient weight-for-age and height-for-age values were compared to U.S.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec07263c4329612840f782bb5fe4d8c
https://doi.org/10.1158/1078-0432.22464185.v1
https://doi.org/10.1158/1078-0432.22464185.v1
Autor:
Brigitte C. Widemann, Jack F. Shern, John W. Glod, Paul S. Meltzer, Maria J. Merino, Frank M. Balis, Elizabeth Fox, Oxana Kapustina, Steven G. Waguespack, Maya Lodish, Seth M. Steinberg, Eva Dombi, Claudia Derse-Anthony, Haiyan Lei, Yuelin Zhu, Srivandana Akshintala, Ira L. Kraft
Doubling time of calcitonin and CEA for patient #12 was suggestive of progressive disease. Patient #12 experienced best response 434 days after starting vandetanib, with stable lesions in the thyroid bed (showed on T2-weighted MRI of the neck, A) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19839df255ead36a5ece83747a68a1df
https://doi.org/10.1158/1078-0432.22464188
https://doi.org/10.1158/1078-0432.22464188
Autor:
Brigitte C. Widemann, Jack F. Shern, John W. Glod, Paul S. Meltzer, Maria J. Merino, Frank M. Balis, Elizabeth Fox, Oxana Kapustina, Steven G. Waguespack, Maya Lodish, Seth M. Steinberg, Eva Dombi, Claudia Derse-Anthony, Haiyan Lei, Yuelin Zhu, Srivandana Akshintala, Ira L. Kraft
Purpose: Vandetanib is well-tolerated in patients with advanced medullary thyroid carcinoma (MTC). Long-term outcomes and mechanisms of MTC progression have not been reported previously.Experimental Design: We monitored toxicities and disease status
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549078e1f12e692d01fc00ebd014fd07
https://doi.org/10.1158/1078-0432.c.6525638
https://doi.org/10.1158/1078-0432.c.6525638
Autor:
Brigitte C. Widemann, Jack F. Shern, John W. Glod, Paul S. Meltzer, Maria J. Merino, Frank M. Balis, Elizabeth Fox, Oxana Kapustina, Steven G. Waguespack, Maya Lodish, Seth M. Steinberg, Eva Dombi, Claudia Derse-Anthony, Haiyan Lei, Yuelin Zhu, Srivandana Akshintala, Ira L. Kraft
Doubling time of calcitonin and CEA during vandetanib therapy. Calcitonin and CEA slopes and doubling times were calculated from the change during the initial four months of vandetanib (A,B), from values the year before experiencing PD or the data cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283a44cfd87e77e11188f6b9cc1f255d
https://doi.org/10.1158/1078-0432.22464191.v1
https://doi.org/10.1158/1078-0432.22464191.v1
Autor:
Brigitte C. Widemann, Jack F. Shern, John W. Glod, Paul S. Meltzer, Maria J. Merino, Frank M. Balis, Elizabeth Fox, Oxana Kapustina, Steven G. Waguespack, Maya Lodish, Seth M. Steinberg, Eva Dombi, Claudia Derse-Anthony, Haiyan Lei, Yuelin Zhu, Srivandana Akshintala, Ira L. Kraft
Patients #2, #5, #10, #11, #13, #15, and #16 experienced durable SD or PR during the follow up period. Calcitonin and CEA are shown as percent change from baseline at the start of vandetanib therapy (left y-axis). Tumor size is the sum of longest dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12df7107083c0e2c68e688498aa0c261
https://doi.org/10.1158/1078-0432.22464197
https://doi.org/10.1158/1078-0432.22464197