Zobrazeno 1 - 10
of 45
pro vyhledávání: '"John W, Earl"'
Autor:
Andrew J. McLachlan, Peter J. Shaw, Ian Kerridge, Howard Gurney, Yiu-Lam Kwan, Judith Trotman, Christa E. Nath, Ian Nivison-Smith, L. Zeng, Douglas E. Joshua, Campbell Tiley, John W. Earl, Peter Presgrave
Publikováno v:
British Journal of Clinical Pharmacology. 82:149-159
Aim High dose melphalan (HDM) and autologous stem cell transplantation (ASCT) retains a central role in the treatment of myeloma. The aim of this study was to determine whether HDM exposure (area under the concentration vs. time curve, AUC), is signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33fbffb0e771079b08cc475035dbc7a3
https://doi.org/10.1111/bcp.12906
https://doi.org/10.1111/bcp.12906
Autor:
John W. Earl, Tracey A. O'Brien, Sundar Rao Koyyalamudi, Jennifer A. Byrne, Christa E. Nath, Unnikrishnan Kuzhiumparambil, Peter J. Shaw, Chris Fraser
© The Author 2015. Published by Oxford University Press. Treosulfan (l-threitol-1,4-di-methanesulfonate) is a prodrug of a bifunctional alkylating agent that is being used increasingly in pediatric bone marrow transplantation regimens. The activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5e0f659d5a91954fa6dfe7340c99af
https://hdl.handle.net/10453/73220
https://hdl.handle.net/10453/73220
Autor:
Esther M Tantsis, Sushil Bandodkar, Kristina Prelog, Kavitha Kothur, John W. Earl, Fiona Tea, Fabienne Brilot, Louise Wienholt, Sudarshini Ramanathan, Russell C. Dale
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149411 (2016)
PLoS ONE
PLoS ONE
Background Myelin oligodendrocyte glycoprotein antibody (MOG Ab) associated demyelination represents a subgroup of autoimmune demyelination that is separate from multiple sclerosis and aquaporin 4 IgG-positive NMO, and can have a relapsing course. Un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab226caf9a49b94406e45b54c1c2789
http://europepmc.org/articles/PMC4769285?pdf=render
http://europepmc.org/articles/PMC4769285?pdf=render
Autor:
Kumudika de Silva, Richard Whittington, Karren M. Plain, John W. Earl, Douglas J. Begg, Auriol C. Purdie
Publikováno v:
Infection and Immunity. 79:3821-3832
Virulent mycobacterial infections progress slowly, with a latent period that leads to clinical disease in a proportion of cases. Mycobacterium avium subsp. paratuberculosis is an intracellular pathogen that causes paratuberculosis or Johne's disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433a0ea5cfc3b2715331ba2306322d9a
https://doi.org/10.1128/iai.05204-11
https://doi.org/10.1128/iai.05204-11
Autor:
Michael Stormon, Kay Montgomery, Elisabeth M Hodson, Katherine R. Stephen, Peter J. Shaw, Andrew J. McLachlan, John C. Coakley, John W. Earl, Elaine Y. L. Blair, Christa E. Nath, L. Zeng
Publikováno v:
British Journal of Clinical Pharmacology. 70:567-579
AIMS To characterize the population pharmacokinetics of mycophenolic acid (MPA) and evaluate dose regimens using a simulation approach and accepted therapeutic drug monitoring targets in children and young people undergoing blood or marrow, kidney an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6553c906e67a09a8160172f01571133e
https://doi.org/10.1111/j.1365-2125.2010.03734.x
https://doi.org/10.1111/j.1365-2125.2010.03734.x
Autor:
Victor S.C. Fung, Russell C. Dale, Henry Houlden, John W. Earl, Anna Melchers, Padraic Grattan-Smith
Publikováno v:
Developmental Medicine & Child Neurology. 52:583-586
Paroxysmal exercise-induced dystonia (PED) is one of the rarer forms of paroxysmal dyskinesia, and can occur in sporadic or familial forms. We report a family (male index case, mother and maternal grandfather) with autosomal dominant inheritance of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f3350f2c5567dc43634ad788477694
https://doi.org/10.1111/j.1469-8749.2010.03619.x
https://doi.org/10.1111/j.1469-8749.2010.03619.x
Autor:
Howard Gurney, Yiu Lam Kwan, Peter J. Shaw, John W. Earl, Ian Kerridge, Douglas E. Joshua, Gareth Hegarty, Christa E. Nath, Andrew J. McLachlan, Campbell Tiley, Peter Presgrave, L. Zeng, Judith Trotman, Stephen B. Duffull
Publikováno v:
British Journal of Clinical Pharmacology. 69:484-497
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • There has been one previous population pharmacokinetic analysis of total melphalan given as a short infusion in 84 adults (mixed diagnoses) and creatinine clearance and body size were found to be important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b3ab8b4221cb8cce9e309a6b85a68c8
https://doi.org/10.1111/j.1365-2125.2010.03638.x
https://doi.org/10.1111/j.1365-2125.2010.03638.x
Autor:
Peter J. Shaw, John C. Coakley, Elaine Y. L. Blair, K. Stephen, L. Zeng, Christa E. Nath, Andrew J. McLachlan, John W. Earl
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:2918-2927
Acyclovir is effective in the prevention and treatment of herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. The aim of this study was to characterize the population pharmacokinetics of acyclovir observed following treatment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852fa35ecb900c438455be5250536fc5
https://doi.org/10.1128/aac.01138-08
https://doi.org/10.1128/aac.01138-08
Publikováno v:
Developmental Medicine & Child Neurology. 51:317-323
Aim Cerebrospinal fluid (CSF) neopterin production is increased by interferon-gamma stimulation and appears to act as a marker of intrathecal immune activation. We aimed to test the usefulness of elevated CSF neopterin as a biological marker of centr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f392c80bfc2aba8ac8a6ceb5efd4c7c
https://doi.org/10.1111/j.1469-8749.2008.03225.x
https://doi.org/10.1111/j.1469-8749.2008.03225.x
Publikováno v:
Biomedical Chromatography. 23:92-100
A simple, accurate and sensitive HPLC method was developed for measuring total and unbound mycophenolic acid (MPA) in human plasma. Total MPA was extracted by protein precipitation and ultrafiltration was used to assess unbound MPA concentrations. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a80dcb78a5a2f55dce37dc61a62d4b
https://doi.org/10.1002/bmc.1088
https://doi.org/10.1002/bmc.1088