Zobrazeno 1 - 10
of 25
pro vyhledávání: '"John W, Carpenter"'
Autor:
Bingfa Sun, Francis S. Willard, Dan Feng, Jorge Alsina-Fernandez, Qi Chen, Michal Vieth, Joseph D. Ho, Aaron D. Showalter, Cynthia Stutsman, Liyun Ding, Todd M. Suter, James D. Dunbar, John W. Carpenter, Faiz Ahmad Mohammed, Eitaro Aihara, Robert A. Brown, Ana B. Bueno, Paul J. Emmerson, Julie S. Moyers, Tong Sun Kobilka, Matthew P. Coghlan, Brian K. Kobilka, Kyle W. Sloop
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(13)
Significance Tirzepatide is a dual agonist of the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), which are incretin receptors that regulate carbohydrate metabolism. This investigational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea64932e0e7ad1a4e2bcef69f757e2ca
https://pubmed.ncbi.nlm.nih.gov/35333651
https://pubmed.ncbi.nlm.nih.gov/35333651
Autor:
John W. Carpenter
Publikováno v:
Annals of the New York Academy of Sciences. 134:24-29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2aacc02e833e9539e43afe564324e1
https://doi.org/10.1111/j.1749-6632.1965.tb56138.x
https://doi.org/10.1111/j.1749-6632.1965.tb56138.x
Autor:
John E. Scott, John W. Carpenter
Publikováno v:
Analytical Biochemistry. 316:82-91
Homogeneous antibody-free assays of protein kinase activity have great utility in high-throughput screening in support of drug discovery. In an effort to develop such an assay, we have used a pair of fluorescein-labeled peptides of identical amino ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb647b7c88358c4f0fd04b077fca266a
https://doi.org/10.1016/s0003-2697(03)00036-8
https://doi.org/10.1016/s0003-2697(03)00036-8
Publikováno v:
Biochemistry. 36:3640-3644
Ras proteins cycle between active, guanosine triphosphate (GTP)-bound and inactive, guanosine diphospate (GDP)-bound states to mediate signal transduction pathways that promote cell growth and differentiation. It is believed that the major physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afed6e5615979cfe0e0bd6c205e830fc
https://doi.org/10.1021/bi962790o
https://doi.org/10.1021/bi962790o
Autor:
Sharon L. Campbell, Sheng Zhong, Robert M. Bell, Sujoy Ghosh, Helen R. Mott, John W. Carpenter
Publikováno v:
Proceedings of the National Academy of Sciences. 93:8312-8317
The Raf-1 protein kinase is the best-characterized downstream effector of activated Ras. Interaction with Ras leads to Raf-1 activation and results in transduction of cell growth and differentiation signals. The details of Raf-1 activation are unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774623c4bfa109c87f89a1f178868b01
https://doi.org/10.1073/pnas.93.16.8312
https://doi.org/10.1073/pnas.93.16.8312
Publikováno v:
Journal of Epilepsy. 6:118-121
Erythrocyte macrocytosis is noted in patients taking valproate with serum levels > 100 μg/ml. We postulated valproate affects membrane structure directly by altering membrane phospholipids. Patients were selected from a chronic care facility, had kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56011331d9689b370213fc9b9596895b
https://doi.org/10.1016/s0896-6974(05)80100-8
https://doi.org/10.1016/s0896-6974(05)80100-8
Autor:
Richard G. Israel, Hisham A. Barakat, Joseph A. Houmard, Judy Heath, John W. Carpenter, Tibor Hortobágyi
Publikováno v:
European Journal of Applied Physiology and Occupational Physiology. 67:226-230
The purpose of this study was to determine the effects of short-term exercise cessation on lipid and lipoprotein profile and insulin sensitivity in highly trained runners (n = 12; mean age 19.9 years) and power athletes (n = 12; mean age 24.4 years).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132bcb51809bc31ffbd8bb644eb21386
https://doi.org/10.1007/bf00864220
https://doi.org/10.1007/bf00864220
Autor:
Robert W. Siegel, Dotzlaf Joe Edward, John W. Carpenter, Dawn P. G. Brown, Chin Liu, P.G. Mitchell, Michael Robert Wiley, Kannan Thirunavukkarasu, D. A. Laska, Jothirajah Marimuthu, Quincy L. Carter, I.J. Brittain, Craig A. Swearingen, James Lee Toth, Timothy B. Durham, Kevin L. Duffin
Publikováno v:
Osteoarthritis and cartilage. 18(9)
Summary Objective Proteolytic degradation of aggrecan in articular cartilage is a hallmark feature of osteoarthritis (OA). The present study was aimed at developing a sensitive enzyme linked immunosorbent assay (ELISA) for the detection of aggrecanas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be00dbc5ba2736c176a0cdbe5d9ad4f
https://pubmed.ncbi.nlm.nih.gov/20633682
https://pubmed.ncbi.nlm.nih.gov/20633682
Autor:
Jose F. Caro, Virginia D. McLendon, Kevin O'Brien, Nancy Legett, Hisham A. Barakat, Richard H.L. Marks, John W. Carpenter
Publikováno v:
Metabolism. 40:280-285
Intra-abdominal liver biopsies were obtained during surgery from fasted obese patients with non-insulin-dependent diabetes mellitus (NIDDM), obese normoglycemic controls, and lean controls. Lipid synthesis was studied in freshly isolated hepatocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d4270d33630772c4146364cf5fd9a5
https://doi.org/10.1016/0026-0495(91)90110-i
https://doi.org/10.1016/0026-0495(91)90110-i
Autor:
Virginia D. McLendon, John W. Carpenter, Hisham A. Barakat, Richard H.L. Marks, Nancy Leggett, Judith Heath, P. Khazanie
Publikováno v:
Diabetes. 39:1527-1533
The possible causes of the enhanced risk for coronary heart disease (CHD) were examined in morbidly obese women with normoglycemia, impaired glucose tolerance (IGT), and non-insulin-dependent diabetes mellitus (NIDDM) before and after gastric bypass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ffc48bc51c7fdcd74e917a9a305665
https://doi.org/10.2337/diab.39.12.1527
https://doi.org/10.2337/diab.39.12.1527