Zobrazeno 1 - 10
of 281
pro vyhledávání: '"John W, Babich"'
A suitable time point for quantifying the radiochemical purity of 225Ac-labeled radiopharmaceuticals
Autor:
James M. Kelly, Alejandro Amor-Coarasa, Elizabeth Sweeney, Justin J. Wilson, Patrick W. Causey, John W. Babich
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Background As 225Ac-labeled radiopharmaceuticals continue to show promise as targeted alpha therapeutics, there is a growing need to standardize quality control (QC) testing procedures. The determination of radiochemical purity (RCP) is an e
Externí odkaz:
https://doaj.org/article/c59c17ba332543ec9ee3b46b82a49a5a
Publikováno v:
Translational Oncology, Vol 22, Iss , Pp 101450- (2022)
The validation of prostate specific membrane antigen (PSMA) as a molecular target in metastatic castration-resistant prostate cancer has stimulated the development of multiple classes of theranostic ligands that specifically target PSMA. Theranostic
Externí odkaz:
https://doaj.org/article/1b2c96b4f70244afb417a188da40e024
Autor:
Wenchao Qu, Bao Hu, John W. Babich, Nicole Waterhouse, Marybeth Dooley, Shashikanth Ponnala, Julie Urgiles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Convenient and fast methods to introduce 11C into organic molecules are of great help for molecular imaging studies. Here, the authors developed an efficient incorporation of [11C]CO2 and [11C]CH3I into molecules via a fluoride-mediated desilylation
Externí odkaz:
https://doaj.org/article/36c86449efb34b8ea72c8e66f8f2890f
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-8 (2020)
Abstract Background Here we report on the comprehensive quality control of a 4.04 GBq (109 mCi) generator supplied by itG (Munich, Germany), and used for routine production of [68Ga]Ga-PSMA-11 for clinical imaging. The performance of the 4.04 GBq itG
Externí odkaz:
https://doaj.org/article/044a715bc8fe4c8b8951a292df520dbe
Autor:
James M. Kelly, Thomas M. Jeitner, Nicole N. Waterhouse, Wenchao Qu, Ethan J. Linstad, Banafshe Samani, Clarence Williams, Anastasia Nikolopoulou, Alejandro Amor-Coarasa, Stephen G. DiMagno, John W. Babich
Publikováno v:
Molecules, Vol 27, Iss 5, p 1552 (2022)
Cancer cells require lipids to fulfill energetic, proliferative, and signaling requirements. Even though these cells can take up exogenous fatty acids, the majority exhibit a dependency on de novo fatty acid synthesis. Fatty acid synthase (FASN) is t
Externí odkaz:
https://doaj.org/article/3c359e76b2464d68aabac98b8253548d
Autor:
Alejandro Amor-Coarasa, James M. Kelly, Pradeep K. Singh, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, Yogindra Vedvyas, Moonsoo M. Jin, J. David Warren, John W. Babich
Publikováno v:
Molecules, Vol 24, Iss 8, p 1612 (2019)
Determining chemokine receptor CXCR4 expression is significant in multiple diseases due to its role in promoting inflammation, cell migration and tumorigenesis. [68Ga]Pentixafor is a promising ligand for imaging CXCR4 expression in multiple tumor typ
Externí odkaz:
https://doaj.org/article/5a56847e5c1d40c8832a2599259bda54
Autor:
Paul S. Donnelly, John W. Babich, Shashikanth Ponnala, James M. Kelly, Stephen G. DiMagno, Nicholas Zia, Alejandro Amor-Coarasa, David J. Schlyer, Clarence Williams, Anastasia Nikolopoulou
Publikováno v:
Molecular Pharmaceutics. 17:1954-1962
The application of small molecules targeting prostate-specific membrane antigen (PSMA) has emerged as a highly promising clinical strategy for visualization and treatment of prostate cancer. Ligands that integrate the ability to both quantify the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dcc5497c996702e721cc735d01edff8
https://doi.org/10.1021/acs.molpharmaceut.0c00060
https://doi.org/10.1021/acs.molpharmaceut.0c00060
Autor:
Silky Pahlajani, P. David Mozley, Sadek Nehmeh, Xiuyuan Wang, Henry Rusinek, Neil Theise, Mony J. de Leon, Yi Li, Emily Tanzi, John W. Babich, Sara Strauss, Elizabeth Pirraglia, Nobuyuki Okamura, Lidia Glodzik, Tracy Butler, Liangdong Zhou, Roxana O. Carare
Publikováno v:
Fluids and Barriers of the CNS. 19
Background In sporadic Alzheimer’s disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship is not well established in living humans. CSF clearance, a major feature of brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca063d8c8b153a529727b5f897b2cdd
https://doi.org/10.1186/s12987-022-00318-y
https://doi.org/10.1186/s12987-022-00318-y
Autor:
Alejandro Amor-Coarasa, James M. Kelly, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, John W. Babich
Publikováno v:
Molecules, Vol 23, Iss 10, p 2575 (2018)
Emerging interest in extending the plasma half-life of small molecule radioligands warrants a consideration of the appropriate radionuclide for PET imaging at longer time points (>8 h). Among candidate positron-emitting radionuclides, 66Ga (t1/2 = 9.
Externí odkaz:
https://doaj.org/article/c5719628961c425485cc6e0dddb22e39
Autor:
James M. Kelly, John W. Babich
Publikováno v:
Current cardiology reports. 24(3)
Purpose of ReviewSuccessful treatment of cancer can be hampered by the attendant risk of cardiotoxicity, manifesting as cardiomyopathy, left ventricle systolic dysfunction and, in some cases, heart failure. This risk can be mitigated if the injury to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c121d0e6060411fd7699d85f5031949
https://pubmed.ncbi.nlm.nih.gov/35028820
https://pubmed.ncbi.nlm.nih.gov/35028820