Zobrazeno 1 - 10
of 1 336
pro vyhledávání: '"John V. Reynolds"'
Autor:
Eimear Mylod, Fiona O’Connell, Noel E. Donlon, Maria Davern, Caroline Marion, Christine Butler, John V. Reynolds, Joanne Lysaght, Melissa J. Conroy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Oesophagogastric adenocarcinomas (OAC) are poor prognosis, obesity-associated cancers which may benefit from natural killer (NK) cell-based immunotherapies. Cellular immunotherapies encounter two key challenges to their success in OAC, namel
Externí odkaz:
https://doaj.org/article/893b5ecdb958437faa29914c40f247e8
Autor:
Mariagiulia Dal Cero, Joan Gibert, Luis Grande, Marta Gimeno, Javier Osorio, Maria Bencivenga, Uberto Fumagalli Romario, Riccardo Rosati, Paolo Morgagni, Suzanne Gisbertz, Wojciech P. Polkowski, Lucio Lara Santos, Piotr Kołodziejczyk, Wojciech Kielan, Rossella Reddavid, Johanna W. van Sandick, Gian Luca Baiocchi, Ines Gockel, Andrew Davies, Bas P. L. Wijnhoven, Daniel Reim, Paulo Costa, William H. Allum, Guillaume Piessen, John V. Reynolds, Stefan P. Mönig, Paul M. Schneider, Elisenda Garsot, Emma Eizaguirre, Mònica Miró, Sandra Castro, Coro Miranda, Xavier Monzonis-Hernández, Manuel Pera, on behalf of the Spanish EURECCA Esophagogastric Cancer Group and the European GASTRODATA Study Group
Publikováno v:
Cancers, Vol 16, Iss 13, p 2463 (2024)
Background: Radical gastrectomy remains the main treatment for gastric cancer, despite its high mortality. A clinical predictive model of 90-day mortality (90DM) risk after gastric cancer surgery based on the Spanish EURECCA registry database was dev
Externí odkaz:
https://doaj.org/article/512cdc1d1ebd4fa3956cf82f6ec8f73c
Autor:
Maria Davern, Cillian O’ Donovan, Noel E. Donlon, Eimear Mylod, Caoimhe Gaughan, Anshul Bhardwaj, Andrew D. Sheppard, Dara Bracken-Clarke, Christine Butler, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Melissa J. Conroy
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 819 (2024)
The presence of an immunosuppressive tumour microenvironment in oesophageal adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment strategies are required to supplement current regimens and improve patient survival. This study
Externí odkaz:
https://doaj.org/article/3ca4eb6b6a0845a7a2adb872372af596
Autor:
Croí E. Buckley, Rebecca M. O’Brien, Timothy S. Nugent, Noel E. Donlon, Fiona O’Connell, John V. Reynolds, Adnan Hafeez, Diarmuid S. O’Ríordáin, Robert A. Hannon, Paul Neary, Reza Kalbassi, Brian J. Mehigan, Paul H. McCormick, Cara Dunne, Michael E. Kelly, John O. Larkin, Jacintha O’Sullivan, Niamh Lynam-Lennon
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Resistance to neoadjuvant chemoradiation therapy, is a major challenge in the management of rectal cancer. Increasing evidence supports a role for altered energy metabolism in the resistance of tumours to anti-cancer therapy, suggesting that targetin
Externí odkaz:
https://doaj.org/article/3e43e6fdd76b4196a34b0a99aec3c412
Autor:
Maria Davern, Caoimhe Gaughan, Fiona O’ Connell, Brendan Moran, Eimear Mylod, Andrew D. Sheppard, Sinead Ramjit, Jasmine Yun-Tong Kung, James J. Phelan, Matthew G. Davey, Eanna J. Ryan, Christine Butler, Laura Quinn, Claudine Howard, Emily Tone, Eimear Phoenix, Waqas T. Butt, Niamh Lynam-Lennon, Stephen G. Maher, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Noel E. Donlon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThis timely study assesses the immunosuppressive effects of surgery on cytotoxic Th1-like immunity and investigates if immune checkpoint blockade (ICB) can boost Th1-like immunity in the perioperative window in upper gastrointestinal canc
Externí odkaz:
https://doaj.org/article/e9a76b77fe4448bca0dc1485f4477ae2
Autor:
Sarah Bennett, Conor F. Murphy, Michelle Fanning, John V. Reynolds, Suzanne L. Doyle, Claire L. Donohoe
Publikováno v:
Clinical Nutrition Open Science, Vol 41, Iss , Pp 44-61 (2022)
Summary: Background and Aims: Oesophagectomy is the primary curative treatment for oesophageal cancer but is associated with considerable postoperative morbidity and mortality. To better understand the aetiology of impaired health-related quality of
Externí odkaz:
https://doaj.org/article/01e855515d38491cbd0fc9a660399d68
Autor:
Maria Davern, Rebecca M. O’ Brien, Jason McGrath, Noel E. Donlon, Ashanty M. Melo, Croí E. Buckley, Andrew D. Sheppard, John V. Reynolds, Niamh Lynam-Lennon, Stephen G. Maher, Joanne Lysaght
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Chemotherapy upregulates immune checkpoint (IC) expression on the surface of tumour cells and IC-intrinsic signalling confers a survival advantage against chemotherapy in several cancer-types including oesophageal adenocarcinoma (OAC). Howev
Externí odkaz:
https://doaj.org/article/dc1658cc2c1c4f7893802d0bf5e392a0
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-18 (2022)
Abstract Background Dysphagia is prevalent in oesophageal cancer with significant clinical and psychosocial complications. The purpose of this study was i) to examine the impact of exercise-based dysphagia rehabilitation on clinical and quality of li
Externí odkaz:
https://doaj.org/article/9b9b03552f3949bc82dfcca78403a0e2
Autor:
Margaret Walshe, John V Reynolds, Michelle Hayes, Anna Gillman, Brona Wright, Sean Dorgan, Ian Brennan, Claire Donohoe, Julie Regan
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Introduction Dysphagia is a common problem following oesophagectomy, and is associated with aspiration pneumonia, malnutrition, weight loss, prolonged enteral feeding tube dependence, in addition to an extended in-hospital stay and compromised qualit
Externí odkaz:
https://doaj.org/article/61bf7cd2a11c4af8b64b1fd635d5deab
Autor:
Magnus Nilsson, Halla Olafsdottir, Gabriella Alexandersson von Döbeln, Fernanda Villegas, Giovanna Gagliardi, Mats Hellström, Qiao-Li Wang, Hemming Johansson, Val Gebski, Jakob Hedberg, Fredrik Klevebro, Sheraz Markar, Elizabeth Smyth, Pernilla Lagergren, Ghazwan Al-Haidari, Lars Cato Rekstad, Eirik Kjus Aahlin, Bengt Wallner, David Edholm, Jan Johansson, Eva Szabo, John V. Reynolds, CS Pramesh, Naveen Mummudi, Amit Joshi, Lorenzo Ferri, Rebecca KS Wong, Chris O’Callaghan, Jelena Lukovic, Kelvin KW Chan, Trevor Leong, Andrew Barbour, Mark Smithers, Yin Li, Xiaozheng Kang, Feng-Ming Kong, Yin-Kai Chao, Tom Crosby, Christiane Bruns, Hanneke van Laarhoven, Mark van Berge Henegouwen, Richard van Hillegersberg, Riccardo Rosati, Guillaume Piessen, Giovanni de Manzoni, Florian Lordick
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundThe globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment leads to around 60% overall
Externí odkaz:
https://doaj.org/article/c303a3a5e5d942c9a1b8efb0a9d35233