Výsledky vyhledávání - "John V. McDowell"

Structure of Factor H-binding Protein B (FhbB) of the Periopathogen, Treponema denticola

Autor: Daniel H. Conrad, Annie Heroux, Jessica K. Bell, John W. Burgner, John V. McDowell, Daniel P. Miller, Richard T. Marconi

Publikováno v: Journal of Biological Chemistry. 287:12715-12722

Periodontitis is the most common disease of microbial etiology in humans. Periopathogen survival is dependent upon evasion of complement-mediated destruction. Treponema denticola, an important contributor to periodontitis, evades killing by the alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8a4e1a97b3f3b0c36611098999ace9f
https://doi.org/10.1074/jbc.m112.339721

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Identification of the primary mechanism of complement evasion by the periodontal pathogen, Treponema denticola

Autor: Richard T. Marconi, Daniel P. Miller, M.P. Goetting-Minesky, Jesse Frederick, H. Goodman, J.C. Fenno, John V. McDowell

Publikováno v: Molecular Oral Microbiology. 26:140-149

Summary Treponema denticola, a periodontal pathogen, binds the complement regulatory protein Factor H (FH). Factor H binding protein B (FhbB) is the sole FH binding protein produced by T. denticola. The interaction of FhbB with FH is unique in that F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::619881a75849db893843bbd0826e2b6f
https://doi.org/10.1111/j.2041-1014.2010.00598.x

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Analysis of a Unique Interaction between the Complement Regulatory Protein Factor H and the Periodontal Pathogen Treponema denticola

Autor: Richard T. Marconi, Bernice Huang, J. Christopher Fenno, John V. McDowell

Publikováno v: Infection and Immunity. 77:1417-1425

Treponema denticola , a spirochete associated with periodontitis, is abundant at the leading edge of subgingival plaque, where it interacts with gingival epithelia. T. denticola produces a number of virulence factors, including dentilisin, a protease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b5f6955012e2f05940408f9cf597bc
https://doi.org/10.1128/iai.01544-08

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Complete Genome Sequence of Sphingobacterium sp. Strain ML3W, Isolated from Wings of Myotis lucifugus Infected with White Nose Syndrome

Autor: Stephen P. Krasucki, Virginia L. Balke, John V. McDowell, Stephen A. Smith

Publikováno v: Genome Announcements

Sphingobacterium sp. strain ML3W was isolated from the wing of a bat infected with white nose syndrome. We report the complete 5.33-Mb genome sequence of Sphingobacterium sp. strain ML3W, obtained using Pacific Biosciences technology. Being the secon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a945caef0960d871cf1b5af64d22b8
https://doi.org/10.1128/genomea.01477-14

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Putative Coiled-Coil Structural Elements of the BBA68 Protein of Lyme Disease Spirochetes Are Required for Formation of Its Factor H Binding Site

Autor: John V. McDowell, Elizabeth A. Rogers, Matthew E. Harlin, Richard T. Marconi

Publikováno v: Journal of Bacteriology. 187:1317-1323

Factor H and factor H like-protein 1 (FHL-1) are complement regulatory proteins that serve as cofactors for the factor I-mediated cleavage of C3b. Some Lyme disease and relapsing fever spirochete species bind factor H to their surface to facilitate i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285438a7764fca70df4e6f044928b014
https://doi.org/10.1128/jb.187.4.1317-1323.2005

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Analysis of the complement sensitivity of oral treponemes and the potential influence of FH binding, FH cleavage and dentilisin activity on the pathogenesis of periodontal disease

Autor: Jessica K. Bell, Daniel P. Miller, John V. McDowell, M.P. Goetting-Minesky, J.C. Fenno, Richard T. Marconi

Treponema denticola, a periopathogen, evades complement-mediated killing by binding the negative complement regulatory protein factor H (FH) to its surface via the FhbB protein. Paradoxically, bound FH is cleaved by T. denticola's dentilisin protease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8e8b9752626505aa9bd8e1491c6a8d
https://europepmc.org/articles/PMC4165728/

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Evidence for the Contribution of Point Mutations tovlsEVariation and for Apparent Constraints on the Net Accumulation of Sequence Changes invlsEduring Infection with Lyme Disease Spirochetes

Autor: John V. McDowell, Shian-Ying Sung, Richard T. Marconi

Publikováno v: Journal of Bacteriology. 183:5855-5861

In the Lyme disease spirochetes, both theospEandvlsEgene families have been demonstrated to undergo sequence variation during infection. To further investigate the mechanisms associated with the generation ofvlsvariation, single-nucleotide polymorphi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac25f2d986c60bde91cbbb9059f5902
https://doi.org/10.1128/jb.183.20.5855-5861.2001

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Analysis of Mechanisms Associated with Loss of Infectivity of Clonal Populations of Borrelia burgdorferi B31MI

Autor: Jon T. Skare, Richard T. Marconi, Maria Labandeira-Rey, Shian Ying Sung, John V. McDowell

Publikováno v: Infection and Immunity. 69:3670-3677

Numerous studies have provided suggestive evidence that the loss of plasmids correlates with the loss of infectivity of the Lyme disease spirochetes. In this study we have further investigated this correlation. Clonal populations were obtained from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5530c07e21ff4e93d997fae56f321c5
https://doi.org/10.1128/iai.69.6.3670-3677.2001

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