Výsledky vyhledávání - "John V. Kushleika"

The Contribution of Dental Amalgam to Urinary Mercury Excretion in Children

Autor: Michael D. Martin, Ying Huang, Brian G. Leroux, John V. Kushleika, P. Lynne Simmonds, Jorge Leitão, Mario Bernardo, Timothy A. DeRouen, Henrique Luis, James S. Woods

Publikováno v: Environmental Health Perspectives
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Much attention has focused on potential adverse health effects associated with exposure to mercury and mercury compounds. Of particular public health concern has been possible neurologic impairment associated with prolonged exposure to elemental merc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9210f1a7ec4fa68881f46e63094ac58b
http://europepmc.org/articles/PMC2022658

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Nuclear Factor B Activity Determines the Sensitivity of Kidney Epithelial Cells to Apoptosis: Implications for Mercury-Induced Renal Failure

Autor: William W. Polk, P. Lynne Simmonds, John V. Kushleika, Francisco J. Dieguez-Acuna, James S. Woods, Maureen E. Ellis

Publikováno v: Toxicological Sciences. 82:114-123

Nuclear factor kappa B (NF-kappaB) is a thiol-dependent transcriptional factor that promotes cell survival and protects cells from apoptotic stimuli. Numerous studies have demonstrated increased sensitivity to apoptosis associated with inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d866398fc65f704e321ea09681b095
https://doi.org/10.1093/toxsci/kfh236

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Attenuation of nuclear factor kappa B (NF-kappaB) promotes apoptosis of kidney epithelial cells: a potential mechanism of mercury-induced nephrotoxicity

Autor: Francisco J. Dieguez-Acuña, P. Lynne Simmonds, Maureen E. Ellis, James S. Woods, John V. Kushleika

Publikováno v: Environmental Health Perspectives

Nuclear factor kappa B (NF-kappaB), a pleiotropic transcriptional factor that promotes cell survival and protects cells from apoptosis, requires reduced thiols at critical steps in its activation pathway. Mercuric ion (Hg(2+)), one of the strongest t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b1548f0564b197b5529d2294abfd97
http://europepmc.org/articles/PMC1241252

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Selegiline and lymphocyte superoxide dismutase activities in Parkinson's disease

Autor: Gary M. Franklin, Terri Smith-Weller, James S. Woods, Harvey Checkoway, Philip D. Swanson, John V. Kushleika, Jai Dong Moon

Publikováno v: Annals of Neurology. 39:378-381

Superoxide dismutases (SODs) are metalloenzymes that detoxify superoxide radicals, and occur in cytosolic (Cu,Zn-SOD) and mitochondrial (Mn-SOD) forms in multiple tissues, including brain. A neuroprotective effect against oxide stressor exposures may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701300d711195897555b01ecb2271c95
https://doi.org/10.1002/ana.410390315

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Genetic polymorphisms of superoxide dismutase in Parkinson's disease

Autor: John V. Kushleika, Patricia S. Janssen, Gary M. Franklin, Terri Smith-Weller, Harvey Checkoway, Federico M. Farin, Yolanda Hitosis, Sarah E. Hallagan, Phillip D. Swanson, James S. Woods

Publikováno v: Movement Disorders. 16:705-707

Oxidative stress reactions may contribute to the pathogenesis of Parkinson's disease (PD). The superoxide dismutases potentially play significant roles in PD by detoxifying superoxide radical. We developed genomic DNA and cDNA-based sequencing assays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6541693aaa510cea5558449df918d1
https://doi.org/10.1002/mds.1153

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Cytotoxicity of iron oxide nanoparticles made from the thermal decomposition of organometallics and aqueous phase transfer with Pluronic F127

Autor: John V. Kushleika, Marcela Gonzales, Lee M. Mitsumori, Kannan M. Krishnan, Michael E. Rosenfeld

Publikováno v: Contrast mediamolecular imaging. 5(5)

Magnetic nanoparticles are promising molecular imaging agents due to their relatively high relaxivity and the potential to modify surface functionality to tailor biodistribution. In this work we describe the synthesis of magnetic nanoparticles using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23ab23d164a68af15d8c4108ef7d1df
https://pubmed.ncbi.nlm.nih.gov/20623517

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BIOMARKERS OF KIDNEY INTEGRITY IN CHILDREN AND ADOLESCENTS WITH DENTAL AMALGAM MERCURY EXPOSURE: FINDINGS FROM THE CASA PIA CHILDREN’S AMALGAM TRIAL

Autor: Jorge Leitão, Mario Bernardo, Timothy A. DeRouen, Anna Korpak, James S. Woods, Michael D. Martin, Brian G. Leroux, John V. Kushleika, Tessa Rue, Henrique Luis

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Mercury is toxic to the kidney, and dental amalgam is a source of mercury exposure. Few studies have evaluated the effects of dental amalgam on kidney function in a longitudinal context in children. Here, we evaluated urinary concentrations of glutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f3ae415d5e6d29d4ebc29cb4c9700c
https://europepmc.org/articles/PMC3236600/

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Longitudinal urinary creatinine excretion values among preadolescents and adolescents

Autor: John V. Kushleika, Michael D. Martin, Henrique Luis, Jorge Leitão, Mario Bernardo, Tessa Rue, Tonya Benton, James S. Woods, Brian G. Leroux, Timothy A. DeRouen

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

To present longitudinal urinary creatinine excretion data for developmentally normal children 9–17 years of age. Only extremely limited data have been presented of a longitudinal nature for this age group. Overall, 507 children who participated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c6d0bc837b71d71dbb7680f0e608b0
https://hdl.handle.net/10451/34313

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RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells

Autor: James S. Woods, John V. Kushleika, William W. Polk, P. Lynne Simmonds, Maureen E. Ellis

Publikováno v: American journal of physiology. Cell physiology. 293(3)

Numerous studies have demonstrated a central role of renal tubular epithelial cells in the etiology of kidney injury and disease through the elaboration of inflammatory mediators. However, little is known about the cellular signaling mechanisms invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbd4cbb2d94336d82877930280f94ed
https://pubmed.ncbi.nlm.nih.gov/17615156

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