Výsledky vyhledávání - "John V. Giannone"

Physicochemical Differences in the AH Receptors of the Most TCDD-Susceptible and the Most TCDD-Resistant Rat Strains

Autor: Joanna M. Karasinska, John V. Giannone, Patricia A. Harper, Monique A. Franc, Jouni T. Tuomisto, Matti Viluksela, Raimo Pohjanvirta, Mary Holowenko, Mikko Unkila, Allan B. Okey, Jouko Tuomisto

Publikováno v: Toxicology and Applied Pharmacology. 155:82-95

Long-Evans rats (strain Turku AB; L-E) are at least 1000-fold more sensitive (LD50 about 10 microg/kg) to the acute lethal effects of 2, 3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) than are Han/Wistar (Kuopio; H/W) rats (LD509600 microg/kg). The AH rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fea632ebd3a8616ddb987b6e68ba1a
https://doi.org/10.1006/taap.1998.8565

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Comparative induction of CYP1A1 expression by pyridine and its metabolites

Autor: Jacqueline Fung, Allan B. Okey, John V. Giannone, Michael M. Iba

Publikováno v: Archives of biochemistry and biophysics. 378(2)

We compared pyridine and five of its metabolites in terms of (i) in vivo induction of CYP1A1 expression in the lung, kidney, and liver in the rat and (ii) in vitro binding to, and activation of, the aryl hydrocarbon receptor (AhR) in cytosol from rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4842373e775118498dbf9f257033dbd
https://pubmed.ncbi.nlm.nih.gov/10860547

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Prolonged depletion of AH receptor without alteration of receptor mRNA levels after treatment of cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin

Autor: Wei Li, John V. Giannone, Markus R. Probst, Allan B. Okey

Publikováno v: Biochemical pharmacology. 55(4)

Previous experiments have shown that the total cellular content of the AH receptor (AHR) drops rapidly after exposure of mouse hepatoma cells (Hepa-1) to the potent AHR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); within 6 hr after treatment, l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28a95f7ad353ba812668bec4d2205dd
https://pubmed.ncbi.nlm.nih.gov/9514084

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Characterization of polyclonal antibodies to the aromatic hydrocarbon receptor

Autor: Allan B. Okey, John V. Giannone, Patricia A. Harper

Publikováno v: Canadian journal of physiology and pharmacology. 73(1)

The aromatic hydrocarbon receptor (AHR) is a soluble intracellular protein that mediates most, if not all, the toxic effects of polycyclic aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3-methylcholanthrene. Initial bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af67f4a5b484d7c2445e29f521f73727
https://pubmed.ncbi.nlm.nih.gov/7600455

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