Zobrazeno 1 - 7
of 7
pro vyhledávání: '"John V. Giannaras"'
Autor:
Stephen W. Wright, Bruce Freimark, Jean M. Williams, M. A. Pratta, Ronald L. Magolda, E. C. Arner, Susan R. Sherk, Joseph J. Petraitis, John V. Giannaras
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:851-858
A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β-induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f524fc6f62e35e4cecae110c5d8558a4
https://doi.org/10.1016/0968-0896(96)00053-3
https://doi.org/10.1016/0968-0896(96)00053-3
Autor:
Stephen W. Wright, Douglas Guy Batt, M. A. Pratta, Joseph J. Petraitis, Ronald L. Magolda, E. C. Arner, Susan R. Sherk, John V. Giannaras, Donald Joseph-Phillip Pinto, Orwat Michael James, Ronald L. Corbett, Bruce Freimark, Jean M. Williams, Susan V. Di Meo, Herman F. Stampfli
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:227-234
A series of 2-(arylmethyl)pyridoisothiazolones is reported that inhibit the IL-1 β induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5b6f7bd4ce3596c642a1014e6fbbe1
https://doi.org/10.1016/0968-0896(95)00018-c
https://doi.org/10.1016/0968-0896(95)00018-c
Autor:
Jean M. Williams, James M. Trzaskos, Robert A. Copeland, Stephen Pick, Sherrill Nurnberg, John V. Giannaras, Donald J. P. Pinto, Maryanne B. Covington
Publikováno v:
Proceedings of the National Academy of Sciences. 91:11202-11206
Selective inhibition of the inducible isoform of prostaglandin G/H synthase (cyclooxygenase-2; COX2; EC 1.14.99.1) can be achieved with compounds of the general form of aryl methyl sulfonyls and aryl methyl sulfonamides. DuP 697 and NS-398 are repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1345382814ca74dae8b53a007274c739
https://doi.org/10.1073/pnas.91.23.11202
https://doi.org/10.1073/pnas.91.23.11202
Publikováno v:
Inflammation. 14:389-399
Extracellular phospholipase A2 activity (PLA2) found in the fluid and cells of the peritoneal cavity of rats injected with casein is described. PLA2 activities from both the fluid and cells require Ca2+ and have pH optima of 7. Acid-extraction increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc180f5da57c24f44baa05351c1d0d20
https://doi.org/10.1007/bf00914090
https://doi.org/10.1007/bf00914090
Autor:
John V. Giannaras, Matthew M. Abelman, Lori L. Bostrom, Douglas Guy Batt, Joseph J. Petraitis, S. V. Di Meo, Carl P. Decicco, S W Wright, Ronald L. Corbett, Bruce Freimark
Publikováno v:
Journal of medicinal chemistry. 37(19)
The synthesis, biological evaluation, and structure-activity relationships of a series of N-phenyl heteroaryl-fused isothiazolones are described. These isothiazolones have been shown to exhibit potent, dose-dependent inhibition of IL-1 beta-induced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb449692c186686bb33c7419b2bc8bc1
https://pubmed.ncbi.nlm.nih.gov/7932530
https://pubmed.ncbi.nlm.nih.gov/7932530
Autor:
John V. Giannaras, E. A. Jones, B. D. Jaffee, Neil Richard Ackerman, M. McGowan, Janet S. Kerr
Publikováno v:
Agents and actions. 27(3-4)
The purpose of this study was to investigate the effects of cyclosporine A (CSA) and methotrexate (MTX) as potential immunomodulators in a nonestablished adjuvant arthritis (AA) model. Non-injected hind paw volumes were reduced when AA rats were trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a392b1ca2705f5f3b806be4280d067b
https://pubmed.ncbi.nlm.nih.gov/2801321
https://pubmed.ncbi.nlm.nih.gov/2801321
Publikováno v:
Agents and actions. 27(3-4)
The effects of recombinant interleukin-1 beta (rIL-1 beta), recombinant tumor necrosis factor (rTNF alpha) and two growth factors, basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) on PLA2 activity and prostaglandin E2 (PGE2) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdaa7fec84c3204943318e272dc84dc
https://pubmed.ncbi.nlm.nih.gov/2801329
https://pubmed.ncbi.nlm.nih.gov/2801329