Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine

Autor: John V. Dzimianski, Julianna Han, Giuseppe A. Sautto, Sara M. O’Rourke, Joseph M. Cruz, Spencer R. Pierce, Jeffrey W. Ecker, Michael A. Carlock, Kaito A. Nagashima, Jarrod J. Mousa, Ted M. Ross, Andrew B. Ward, Rebecca M. DuBois

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)

Abstract Influenza virus poses an ongoing human health threat with pandemic potential. Due to mutations in circulating strains, formulating effective vaccines remains a challenge. The use of computationally optimized broadly reactive antigen (COBRA)

Externí odkaz: https://doaj.org/article/d3b5f9c02ac24ad48239a2e279933c19

Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease

Autor: Florine E.M. Scholte, Marko Zivcec, John V. Dzimianski, Michelle K. Deaton, Jessica R. Spengler, Stephen R. Welch, Stuart T. Nichol, Scott D. Pegan, Christina F. Spiropoulou, Éric Bergeron

Publikováno v: Cell Reports, Vol 20, Iss 10, Pp 2396-2407 (2017)

Antiviral responses are regulated by conjugation of ubiquitin (Ub) and interferon-stimulated gene 15 (ISG15) to proteins. Certain classes of viruses encode Ub- or ISG15-specific proteases belonging to the ovarian tumor (OTU) superfamily. Their activi

Externí odkaz: https://doaj.org/article/2913f622b2624efda670531f1ee47f80

Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin

Autor: J.R. McGuire, Kay S. Faaberg, Courtney M. Daczkowski, Scott D. Pegan, John V. Dzimianski, Ian A. Durie

Publikováno v: Acta Crystallogr D Struct Biol

Porcine epidemic diarrhea is a devastating porcine disease that is caused by the alphacoronavirus porcine epidemic diarrhea virus (PEDV). Like other members of the Coronaviridae family, PEDV encodes a multifunctional papain-like protease 2 (PLP2) tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47b5e9ab64630f119e1fa1fe4d249e0
https://doi.org/10.1107/s205979832100509x

Rapid and sensitive detection of SARS-CoV-2 antibodies by biolayer interferometry

Autor: Nicholas Lorig-Roach, Rebecca M. DuBois, John V. Dzimianski, David L. Alexander, Jacqueline M. Kimmey, Sara M. O'Rourke

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
medRxiv, vol 1, iss 07-29
Scientific Reports
medRxiv
article-version (status) pre
article-version (number) 1
Scientific reports, vol 10, iss 1

Serological testing to evaluate antigen-specific antibodies in plasma is generally performed by rapid lateral flow test strips that lack quantitative results or by high complexity immunoassays that are time- and labor-intensive but provide semi-quant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdce7364216c3cb71226233139a52ade
https://doaj.org/article/732073a67aad4d4b950541e95d82a053

The pre-existing human antibody repertoire to computationally optimized influenza H1 hemagglutinin vaccines

Autor: Jarrod J. Mousa, Ted M. Ross, Julianna Han, Andrew B. Ward, John V. Dzimianski, Giuseppe A. Sautto, Aaron D. Gingerich, Kaito Nagashima, Nada Abbadi, Rebecca M. DuBois, Sara M. O'Rourke, Fredejah Royer

The computationally optimized broadly reactive antigen (COBRA) approach has previously been used to generate hemagglutinin (HA) immunogens for several influenza subtypes that expand vaccine-elicited antibody breadth. As nearly all individuals have pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd6f83ff78a78f6f4d5da04d6a31957e
https://doi.org/10.1101/2021.10.25.465669