Zobrazeno 1 - 10
of 10
pro vyhledávání: '"John V Bonacci"'
Autor:
James Ziogas, Hayat Dagher, Jane E. Bourke, John V Bonacci, Simon R. Foster, E. Wee, Tamara B. Harris, X. Li, Alastair G. Stewart
Publikováno v:
European Respiratory Journal. 37:173-182
Bi-directional interactions between airway smooth muscle (ASM) and the altered extracellular matrix (ECM) may influence airway wall remodelling and ASM function in asthma. We have investigated the capacity of cultured human ASM to reorganise the stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f22bba5980a7b3d9bd490dddafa596
https://doi.org/10.1183/09031936.00008109
https://doi.org/10.1183/09031936.00008109
Publikováno v:
British Journal of Pharmacology. 149:365-373
Background and purpose: Airway wall remodelling in asthma is characterised by a number of structural changes, including an increase in the volume of airway smooth muscle (ASM), and the abundance of the extracellular matrix (ECM) protein, collagen, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afaed81793bcb572aace75a9d8e83d65
https://doi.org/10.1038/sj.bjp.0706881
https://doi.org/10.1038/sj.bjp.0706881
Publikováno v:
Current Drug Targets. 7:567-577
Subepithelial fibrosis is one of the characteristic features of asthmatic airways. The fibrotic response includes an increase in volume occupied by extracellular matrix (ECM) tissue, and a change in the ECM composition favouring wound type collagens,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cd127b728335d6fa247ecc8c2f7b05
https://doi.org/10.2174/138945006776818700
https://doi.org/10.2174/138945006776818700
Autor:
Darren J. Fernandes, Jane E. Ward, Lilly Quan, C.C. Taylor, John V Bonacci, Alastair G. Stewart
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 19:39-46
There is considerable interest in the role of peroxisome proliferator activated receptors (PPARs) as ligand-activated transcription factors in the airways. This study examines the effects of a potent synthetic PPARgamma ligand, rosiglitazone (RG), in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c44feffda47f06af59b945508093009
https://doi.org/10.1016/j.pupt.2005.02.005
https://doi.org/10.1016/j.pupt.2005.02.005
Autor:
John V Bonacci, Alastair G. Stewart
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 19:32-38
Altered rates of cell proliferation play important roles in the pathogenesis of a variety of conditions, including cancer, inflammation and several airway and cardiovascular diseases. One of the most consistently observed changes in asthmatic airways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4930328c3fa87bdd3a04aacad8258bb1
https://doi.org/10.1016/j.pupt.2005.02.011
https://doi.org/10.1016/j.pupt.2005.02.011
Autor:
Qutayba Hamid, Elizabeth D. Fixman, Qi Peng, David Ramos-Barbón, Stuart J John Hirst, James G. Martin, Alastair G. Stewart, Clare G. McVicker, John V Bonacci, Lyn M Moir, Jean-Pierre Lavoie, Vivien Chan, Berenice Herszberg, Trang T-B Nguyen
Publikováno v:
Journal of Allergy and Clinical Immunology. 114:S2-S17
Increased airway smooth muscle (ASM) mass is perhaps the most important component of the airway wall remodeling process in asthma. Known mediators of ASM proliferation in cell culture models fall into 2 categories: those that activate receptors with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51fbeaccf0f7f29e1da78d17fbb99b3
https://doi.org/10.1016/j.jaci.2004.04.039
https://doi.org/10.1016/j.jaci.2004.04.039
Publikováno v:
Current Allergy and Asthma Reports. 4:109-115
Airway smooth muscle proliferation has been the focus of considerable attention, as it is a quantitatively important component of the airway wall remodeling response in asthma and has been suggested as a suitable target for the development of novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f3739f50f256c97c67a3d6826aa651
https://doi.org/10.1007/s11882-004-0055-8
https://doi.org/10.1007/s11882-004-0055-8
Publikováno v:
British journal of pharmacology. 141(3)
The influence of two peroxisome proliferator-activated receptor gamma (PPARgamma) ligands, a thiazolidinedione, rosiglitazone (RG) and the prostaglandin D2 metabolite 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) on the proliferation of human cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bff9ab827518ca8f15b87be95b841adf
https://pubmed.ncbi.nlm.nih.gov/14718259
https://pubmed.ncbi.nlm.nih.gov/14718259
Publikováno v:
Clinical and experimental pharmacologyphysiology. 30(5-6)
1. The proliferation of airway smooth muscle (ASM) and collagen deposition are major contributors to airway remodelling in asthma that may be an important component of airway hyperresponsiveness. The ratio of collagen to laminin in asthma is increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0136fb417f9d7ce1291745368b3ca0fb
https://pubmed.ncbi.nlm.nih.gov/12859421
https://pubmed.ncbi.nlm.nih.gov/12859421
Publikováno v:
British journal of pharmacology. 138(7)
Glucocorticoids (GCS) inhibit mitogenesis of airway smooth muscle (ASM) cells grown on plastic. We have now evaluated the effects of GCS on proliferation of ASM grown on extracellular matrix proteins (ECM) abundant in noninflamed airways (laminin) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f818b4058941e421b1ea06294b8973b
https://pubmed.ncbi.nlm.nih.gov/12711613
https://pubmed.ncbi.nlm.nih.gov/12711613