Zobrazeno 1 - 10
of 110
pro vyhledávání: '"John V, Moran"'
Autor:
Chen Sun, Kunal Kathuria, Sarah B. Emery, ByungJun Kim, Ian E. Burbulis, Joo Heon Shin, Brain Somatic Mosaicism Network, Daniel R. Weinberger, John V. Moran, Jeffrey M. Kidd, Ryan E. Mills, Michael J. McConnell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes arise during neurotypical brain development,
Externí odkaz:
https://doaj.org/article/3c1b3462f5dc401c808fdd785991305a
Autor:
McKinzie A. Garrison, Yeongjun Jang, Taejeong Bae, Adriana Cherskov, Sarah B. Emery, Liana Fasching, Attila Jones, John B. Moldovan, Cindy Molitor, Sirisha Pochareddy, Mette A. Peters, Joo Heon Shin, Yifan Wang, Xiaoxu Yang, Schahram Akbarian, Andrew Chess, Fred H. Gage, Joseph G. Gleeson, Jeffrey M. Kidd, Michael McConnell, Ryan E. Mills, John V. Moran, Peter J. Park, Nenad Sestan, Alexander E. Urban, Flora M. Vaccarino, Christopher A. Walsh, Daniel R. Weinberger, Sarah J. Wheelan, Alexej Abyzov, BSMN Consortium
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-18 (2023)
Abstract Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that p
Externí odkaz:
https://doaj.org/article/169288af9ac84d8b8a7875b0a5f4336c
Autor:
Ahmad Luqman-Fatah, Yuzo Watanabe, Kazuko Uno, Fuyuki Ishikawa, John V. Moran, Tomoichiro Miyoshi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-26 (2023)
Proteomic analyses revealed that a group of interferon-stimulated genes suppresses LINE-1 retrotransposon activities, including HELZ2, which reduces LINE-1 RNA and the associated innate immune response levels.
Externí odkaz:
https://doaj.org/article/1eb5dddf7a114310a23918c5a3aac13f
Autor:
Yifan Wang, Taejeong Bae, Jeremy Thorpe, Maxwell A. Sherman, Attila G. Jones, Sean Cho, Kenneth Daily, Yanmei Dou, Javier Ganz, Alon Galor, Irene Lobon, Reenal Pattni, Chaggai Rosenbluh, Simone Tomasi, Livia Tomasini, Xiaoxu Yang, Bo Zhou, Schahram Akbarian, Laurel L. Ball, Sara Bizzotto, Sarah B. Emery, Ryan Doan, Liana Fasching, Yeongjun Jang, David Juan, Esther Lizano, Lovelace J. Luquette, John B. Moldovan, Rujuta Narurkar, Matthew T. Oetjens, Rachel E. Rodin, Shobana Sekar, Joo Heon Shin, Eduardo Soriano, Richard E. Straub, Weichen Zhou, Andrew Chess, Joseph G. Gleeson, Tomas Marquès-Bonet, Peter J. Park, Mette A. Peters, Jonathan Pevsner, Christopher A. Walsh, Daniel R. Weinberger, Brain Somatic Mosaicism Network, Flora M. Vaccarino, John V. Moran, Alexander E. Urban, Jeffrey M. Kidd, Ryan E. Mills, Alexej Abyzov
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Background Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. However, detecting mosai
Externí odkaz:
https://doaj.org/article/ed8ec2a7cb594e94ba5848bb9fd9be5a
Autor:
Ahmad Luqman-Fatah, Yuzo Watanabe, Kazuko Uno, Fuyuki Ishikawa, John V. Moran, Tomoichiro Miyoshi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/e562859a83394e979617355667a0e650
Autor:
Sierra M Mortimer, Trenton J Frisbie, John B Moldovan, Mitsuhiro Nakamura, Siara N Sandwith, John Yin, John V Moran
Publikováno v:
eLS. :1-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8055d16f6388c01e0fc44e69980296ad
https://doi.org/10.1002/9780470015902.a0025409
https://doi.org/10.1002/9780470015902.a0025409
Autor:
Peter A Larson, John B Moldovan, Naveen Jasti, Jeffrey M Kidd, Christine R Beck, John V Moran
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e2003067 (2018)
Human Long interspersed element-1 (L1) retrotransposons contain an internal RNA polymerase II promoter within their 5' untranslated region (UTR) and encode two proteins, (ORF1p and ORF2p) required for their mobilization (i.e., retrotransposition). Th
Externí odkaz:
https://doaj.org/article/797c4d60befd48ef98e00f484c6d3284
Autor:
Jacqueline R Ward, Afshin Khan, Sabrina Torres, Bert Crawford, Sarah Nock, Trenton Frisbie, John V Moran, Michelle S Longworth
Publikováno v:
Nucleic acids research. 50(18)
Condensin I and condensin II are multi-subunit complexes that are known for their individual roles in genome organization and preventing genomic instability. However, interactions between condensin I and condensin II subunits and cooperative roles fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31080fa87699d76caf89aafa6d04143e
https://pubmed.ncbi.nlm.nih.gov/36169232
https://pubmed.ncbi.nlm.nih.gov/36169232
Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells.
Autor:
Jacqueline R Ward, Kommireddy Vasu, Emily Deutschman, Dalia Halawani, Peter A Larson, Dongmei Zhang, Belinda Willard, Paul L Fox, John V Moran, Michelle S Longworth
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007051 (2017)
LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition. This w
Externí odkaz:
https://doaj.org/article/b6c172ada2f4465b888935d27b1d06d7
Autor:
John V. Moran, Thomas E. Wilson
Publikováno v:
Cell. 185(20)
Retrotransposons are selfish genetic elements that encode an enzyme, reverse transcriptase (RT), which converts the element-encoded RNA into DNA prior to or during genomic integration. New studies provide compelling evidence that a bacterial group II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05c425d6f37bcd1d000e26244229153
https://pubmed.ncbi.nlm.nih.gov/36179663
https://pubmed.ncbi.nlm.nih.gov/36179663