Zobrazeno 1 - 10
of 84
pro vyhledávání: '"John V, Fahey"'
Autor:
Zheng Shen, John V Fahey, Jack E Bodwell, Marta Rodriguez-Garcia, Angela D M Kashuba, Charles R Wira
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100863 (2014)
The conflicting results of recent pre-exposure prophylaxis (PrEP) trials utilizing tenofovir (TFV) to prevent HIV infection in women led us to evaluate the accumulation of intracellular TFV-diphosphate (TFV-DP) in cells from the female reproductive t
Externí odkaz:
https://doaj.org/article/988561e1eeab4518a5dad731bc668a01
Estradiol regulation of nucleotidases in female reproductive tract epithelial cells and fibroblasts.
Autor:
Zheng Shen, John V Fahey, Jack E Bodwell, Marta Rodriguez-Garcia, Richard M Rossoll, Sarah G Crist, Mickey V Patel, Charles R Wira
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69854 (2013)
The use of topical and oral adenosine derivatives in HIV prevention that need to be maintained in tissues and cells at effective levels to prevent transmission prompted us to ask whether estradiol could influence the regulation of catabolic nucleotid
Externí odkaz:
https://doaj.org/article/d68a385c19bd45718b5c61300c4b24ac
Autor:
Nabanita Biswas, Marta Rodriguez-Garcia, Sarah G Crist, Zheng Shen, Jack E Bodwell, John V Fahey, Charles R Wira
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78814 (2013)
Tenofovir (TFV) has been widely used for pre-exposure prophylaxis of HIV-1 infection with mixed results. While the use of TFV in uninfected individuals for prevention of HIV-1 acquisition is actively being investigated, the possible consequences of T
Externí odkaz:
https://doaj.org/article/ab9e523dd40142d8a85d66cf29917621
Autor:
Marta Rodriguez-Garcia, Nabanita Biswas, Mickey V Patel, Fiona D Barr, Sarah G Crist, Christina Ochsenbauer, John V Fahey, Charles R Wira
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62069 (2013)
The magnitude of the HIV epidemic in women requires urgent efforts to find effective preventive methods. Even though sex hormones have been described to influence HIV infection in epidemiological studies and regulate different immune responses that m
Externí odkaz:
https://doaj.org/article/b0205a82c121439f8baf73d42dbab8fb
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35654 (2012)
Interferon β (IFNβ) is an antiviral cytokine secreted in response to pathogenic exposure that creates a restrictive intracellular environment through the action of downstream interferon-stimulated genes (ISG). The objective of this study was to exa
Externí odkaz:
https://doaj.org/article/4628d2af1475427aafde8654231a2b79
Autor:
Timothy Lahey, Mimi Ghosh, John V Fahey, Zheng Shen, Lucy R Mukura, Yan Song, Susan Cu-Uvin, Kenneth H Mayer, Peter F Wright, John C Kappes, Christina Ochsenbauer, Charles R Wira
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38100 (2012)
We have previously demonstrated intrinsic anti-HIV activity in cervicovaginal lavage (CVL) from HIV-infected women with high CD4 counts and not on antiretroviral therapy. However, the impact of HIV disease progression on CVL innate immune responses h
Externí odkaz:
https://doaj.org/article/f8f8f5cab2c54cee963d8306323abe61
Autor:
Daniel O Ochiel, Christina Ochsenbauer, John C Kappes, Mimi Ghosh, John V Fahey, Charles R Wira
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14306 (2010)
Sexual transmission accounts for the majority of HIV-1 infections. In over 75% of cases, infection is initiated by a single variant (transmitted/founder virus). However, the determinants of virus selection during transmission are unknown. Host cell-c
Externí odkaz:
https://doaj.org/article/4988a67d8e4042a3a3eb6b733fed6f2c
Autor:
Mimi Ghosh, John V Fahey, Zheng Shen, Timothy Lahey, Susan Cu-Uvin, Zhijin Wu, Kenneth Mayer, Peter F Wright, John C Kappes, Christina Ochsenbauer, Charles R Wira
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11366 (2010)
We investigated the impact of antimicrobials in cervicovaginal lavage (CVL) from HIV(+) and HIV(-) women on target cell infection with HIV. Since female reproductive tract (FRT) secretions contain a spectrum of antimicrobials, we hypothesized that CV
Externí odkaz:
https://doaj.org/article/4fd7364dc83f4da19653ae994521fbb2
Publikováno v:
American Journal of Reproductive Immunology
PROBLEM Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection worldwide and known to increase the risk for HIV acquisition. Few studies have investigated how infection of epithelial cells compromises barrier inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0297d3e080781d9f3e23815136f6934
https://igi.indrastra.com/items/show/38516
https://igi.indrastra.com/items/show/38516
Publikováno v:
American Journal of Reproductive Immunology. 72:236-258
The immune system in the female reproductive tract (FRT) does not mount an attack against human immunodeficiency virus (HIV) or other sexually transmitted infections (STI) with a single endogenously produced microbicide or with a single arm of the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c127b64b59d390271ef18258750a900b
https://doi.org/10.1111/aji.12252
https://doi.org/10.1111/aji.12252