Zobrazeno 1 - 10
of 89
pro vyhledávání: '"John Turton"'
Autor:
Kersti Karu, Martin Hornshaw, Gary Woffendin, Karl Bodin, Mats Hamberg, Gunvor Alvelius, Jan Sjövall, John Turton, Yuqin Wang, William J. Griffiths
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 4, Pp 976-987 (2007)
In humans, the brain accounts for about 20% of the body's free cholesterol, most of which is synthesized de novo in brain. To maintain cholesterol balance throughout life, cholesterol becomes metabolized to 24S-hydroxycholesterol, principally in neur
Externí odkaz:
https://doaj.org/article/b3d9a28fe9394a81ba2837b46d735d15
Publikováno v:
Results in Pharma Sciences. 2:9-15
The interaction between heparin, a polyanion, and a polycationic dendrimer with a glycine core and lysine branches Gly–Lys63(NH2)64 has been investigated. Complexation was assessed by transmission electron microscopy, size and zeta potential measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63880b046dc60a7b232b8004555b8f76
https://doi.org/10.1016/j.rinphs.2011.12.002
https://doi.org/10.1016/j.rinphs.2011.12.002
Autor:
Michael R. Munday, Rosemary Smyth, Malcolm York, John Turton, Jennifer Woodfine, David P. Maguire, Mitul Gandhi, Ines Pereira, John Bowles, Cheryl L. Scudamore, Surjit Sondh, Ian Francis, Aubrey Swain, Sofia Freitas, Clare Stamp, Holly Ashall
Publikováno v:
Journal of Applied Toxicology. 32:417-428
Hexachloro-1:3-butadiene (HCBD) causes damage specifically to the renal proximal tubule in rats. In the present study, injury to the nephron of male Hanover Wistar rats was characterized at 24 h following dosing with HCBD in the range 5–90 mg kg−
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0c373b95656606dc119abe6ab2cb3a
https://doi.org/10.1002/jat.1727
https://doi.org/10.1002/jat.1727
Publikováno v:
Chemistry and Physics of Lipids. 164:411-424
Oxysterols are present in mammalian brain at ng/g–μg/g levels while cholesterol is present at the mg/g level. This makes oxysterol analysis of brain challenging. In an effort to meet this challenge we have developed, and validated, an isolation me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7aa54a00ab470ed4e517c5a1e93330a
https://doi.org/10.1016/j.chemphyslip.2011.04.011
https://doi.org/10.1016/j.chemphyslip.2011.04.011
Publikováno v:
Cell Biology and Toxicology. 27:267-284
The gastrointestinal (GI) tract is an important target organ for the toxicity of xenobiotics. The toxic effects of xenobiotics on this complex, heterogeneous structure have been difficult to model in vitro and have traditionally been assessed in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210925cd4864eeda46343cb9f2f0f820
https://doi.org/10.1007/s10565-011-9187-5
https://doi.org/10.1007/s10565-011-9187-5
Autor:
Jennifer E Podesta, Simon Akerman, Alberto Bianco, Alexander T. Florence, Kostas Kostarelos, Neil Vargesson, Khuloud T. Al-Jamal, Açelya Yilmazer, Gillian M. Tozer, Chryso Kanthou, Wafa' T Al-Jamal, John Turton
Publikováno v:
Proceedings of the National Academy of Sciences. 107:3966-3971
This study describes the previously unreported intrinsic capacity of poly-L-lysine (PLL) sixth generation (G 6 ) dendrimer molecules to exhibit systemic antiangiogenic activity that could lead to solid tumor growth arrest. The PLL-dendrimer-inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc13f8f010c588bf2451f4f2b65ce69
https://doi.org/10.1073/pnas.0908401107
https://doi.org/10.1073/pnas.0908401107
Autor:
Michael R. Munday, Surjit Sondh, Ines Pereira, Cheryl L. Scudamore, Neeti Viswanathan, Aubrey Swain, John Turton, Rosemary Smyth, Malcolm York, Mitul Gandhi, Fiona McClure
Publikováno v:
Journal of Applied Toxicology. 31:366-377
Hexachloro-1:3-butadiene (HCBD) causes kidney injury specific to the pars recta of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4c6b2d5c6fc7029af918474e043bbe
https://doi.org/10.1002/jat.1624
https://doi.org/10.1002/jat.1624
Publikováno v:
Toxicologic Pathology. 37:661-666
Capillaria hepatica is a nematode parasite of wild rodents and other mammals. Adult worms inhabit the liver. Recently, during the necropsy examination of a group of 160 rabbits from a commercial supplier, firm pale or cystic areas (1-5 mm) were noted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66fd75900b400e6538bdb0eddbdc6d2f
https://doi.org/10.1177/0192623309339501
https://doi.org/10.1177/0192623309339501
Publikováno v:
Toxicologic Pathology. 37:170-174
In vitro techniques for the culture of hemopoietic stem cells and committed hemopoietic progenitor cells in rat bone marrow have not been adequately described in the literature. In the present investigations, and using commercially available hemopoie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd00cf9317cb3ce3f6337cd8501474c4
https://doi.org/10.1177/0192623308328133
https://doi.org/10.1177/0192623308328133
Autor:
Charles V. J. Mifsud, Frances M. Gibson, Matthew Whayman, Andrew M. Pilling, Sean McKeag, Harpal K. Marway, Christabelle M. Chen, John Turton, Gemma Molyneux
Publikováno v:
International Journal of Experimental Pathology. 89:138-158
Azathioprine (AZA) is a cytotoxic immunosuppressive drug used in the prevention of rejection in organ transplants and the treatment of auto-immune diseases. However, AZA is haemotoxic causing significant bone marrow depression. The present studies we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fadfec9006da79c3c24d9be067dc89b
https://doi.org/10.1111/j.1365-2613.2008.00575.x
https://doi.org/10.1111/j.1365-2613.2008.00575.x