Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John Tulinsky"'
Autor:
Jack W. Singer, Lynn Bonham, Thayer White, John Tulinsky, Michael Coon, David Hollenback, David W. Leung, Peter S. Klein, Peter de Vries
Publikováno v:
Expert Opinion on Therapeutic Targets. 7:643-661
Phosphatidic acid (PA) is a component of cellular membranes that is also a mediator of certain cell signalling functions associated with oncogenesis. These include ras/raf/Erk and Akt/mTor [1-3]. The authors have investigated whether it would be poss
Autor:
Rama Bhatt, John Tulinsky, Peter S. Klein, Jack W. Singer, Kent R. Buhler, Eveline Heasley, Peter de Vries
Publikováno v:
Journal of Controlled Release. 74:243-247
The therapeutic efficacy of 20(s)-camptothecin (CPT) is limited in humans by the instability of the active lactone form due to preferential binding of the carboxylate to serum albumin and by difficulty in formulation. Formation of an ester bond with
Autor:
Cheney Bv, Steve A. Mizsak, Lester A. Dolak, W. Watt, John Tulinsky, Thomas M. Judge, Ronald B. Gammill, Fusen Han
Publikováno v:
The Journal of Organic Chemistry. 64:93-100
Cyclization of (S,S)-alpha-[(1-phenylethyl)amino]-alpha-(2-iodophenyl)acetonitrile with (COCl)(2) in toluene or chlorobenzene afforded the atropisomeric pyrazinone (aS,S) 6-(2-alpha-iodophenyl)-3,5-dichloro-1-(1-phenylethyl)-2(1H)-pyrazinone in 57% y
Autor:
William Watt, Ronald B. Gammill, Stephen A. Mizsak, Lester A. Dolak, Thomas M. Judge, John Tulinsky
Publikováno v:
Tetrahedron Letters. 36:2017-2020
Cyclization of ( S , S )- α -[(1-phenylethyl)amino]- α -(2-iodophenyl)acetonitrile 3a with (COCl) 2 in toluene or chlorobenzene afforeded the atropisomeric pyrazinone ( aS , S ) 6-(2-α-iodophenyl)-3,5-dichloro-1-(1-phenylethyl)-2(1H)-pyrazinone 7a
Autor:
John Tulinsky, Ronald B. Gammill
Publikováno v:
Current Medicinal Chemistry. 1:226-253
Abstract: The inhibitory neurotransmitter y-aminobutyrate (GA8A) elicits its physiological effects through interactions with two distinct classes of cell surface receptors in the central nervous system. The GA8AA receptor is a member of the superfa
Autor:
Lester A. Dolak, Thomas M. Judge, Ronald B. Gammill, Stephen A. Mizsak, William Watt, John Tulinsky
Publikováno v:
ChemInform. 26
Cyclization of ( S , S )- α -[(1-phenylethyl)amino]- α -(2-iodophenyl)acetonitrile 3a with (COCl) 2 in toluene or chlorobenzene afforeded the atropisomeric pyrazinone ( aS , S ) 6-(2-α-iodophenyl)-3,5-dichloro-1-(1-phenylethyl)-2(1H)-pyrazinone 7a
Autor:
K. D. Lovasz, Karen Rene Romines, Lester A. Dolak, J. M. Tustin, Gillian Phillips, Thomas M. Judge, R. A. Chrusciel, Strohbach Joseph Walter, Joel Morris, S. L. Vander Velde, G. P. Luke, Steve A. Mizsak, Ronald B. Gammill, John Tulinsky, W. Watt
Publikováno v:
ChemInform. 28
Autor:
Lester A. Dolak, Ronald B. Gammill, John Tulinsky, Fusan Han, Thomas M. Judge, W. Watt, Stephen A. Mizsak, B. Vernon Cheney
Publikováno v:
ChemInform. 30
Autor:
K. D. Lovasz, Stephen A. Mizsak, Thomas M. Judge, Karen Rene Romines, Eric P. Seest, John Tulinsky, Jeanette Kay Morris, Ronald B. Gammill, Fusen Han
Publikováno v:
ChemInform. 30
Autor:
Jack W. Singer, Scott A. Jenkins, Rama Bhatt, Peter de Vries, Feng Hong, Baoqing Gong, Peter Klein, Cory Kohm, John Tulinsky
Publikováno v:
ChemInform. 35
2,4-Diamino-N(4),6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an