Zobrazeno 1 - 10
of 110
pro vyhledávání: '"John Trinick"'
Autor:
Charlotte A Scarff, Rebecca F Thompson, George F J Newlands, Alexander H Jamson, Christopher Kennaway, Vivian J da Silva, Elida M Rabelo, Chun-Feng Song, John Trinick, W David Smith, Stephen P Muench
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008465 (2020)
Roundworm parasite infections are a major cause of human and livestock disease worldwide and a threat to global food security. Disease control currently relies on anthelmintic drugs to which roundworms are becoming increasingly resistant. An alternat
Externí odkaz:
https://doaj.org/article/0ff427ede1274c4cb57f1665bf1bf24f
Autor:
Chun Feng Song, Kostas Papachristos, Shaun Rawson, Markus Huss, Helmut Wieczorek, Emanuele Paci, John Trinick, Michael A Harrison, Stephen P Muench
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82207 (2013)
The V-ATPase is a membrane-bound protein complex which pumps protons across the membrane to generate a large proton motive force through the coupling of an ATP-driven 3-stroke rotary motor (V1) to a multistroke proton pump (Vo). This is done with nea
Externí odkaz:
https://doaj.org/article/4968aed92d3641f78b93674272169417
Autor:
Larissa Tskhovrebova, John Trinick
Publikováno v:
PLoS Biology, Vol 10, Iss 2, p e1001264 (2012)
Skeletal and cardiac muscles are remarkable biological machines that support and move our bodies and power the rhythmic work of our lungs and hearts. As well as producing active contractile force, muscles are also passively elastic, which is essentia
Externí odkaz:
https://doaj.org/article/25ea5affcb1248ae96c22da3b4abc05c
Publikováno v:
Journal of Muscle Research and Cell Motility
The Z-disk is a complex structure comprising some 40 proteins that are involved in the transmission of force developed during muscle contraction and in important signalling pathways that govern muscle homeostasis. In the Z-disk the ends of antiparall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e090d72096b0d7455002ea519528bf
Autor:
Larissa, Tskhovrebova, John, Trinick
Publikováno v:
Sub-cellular biochemistry. 82
In this review we discuss the history and the current state of ideas related to the mechanism of size regulation of the thick (myosin) and thin (actin) filaments in vertebrate striated muscles. Various hypotheses have been considered during of more t
Autor:
John Trinick, Larissa Tskhovrebova
Publikováno v:
Subcellular Biochemistry ISBN: 9783319496726
In this review we discuss the history and the current state of ideas related to the mechanism of size regulation of the thick (myosin) and thin (actin) filaments in vertebrate striated muscles. Various hypotheses have been considered during of more t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0a0aa67056b2852a2b844766c6ebbf1
https://doi.org/10.1007/978-3-319-49674-0_10
https://doi.org/10.1007/978-3-319-49674-0_10
Autor:
John Trinick, Matt L. Walker, Yue Jiao, Pierre Montaville, Julien Pernier, Marie-France Carlier
Publikováno v:
Cytoskeleton. 71:170-183
Cordon-Bleu (Cobl) is a regulator of actin dynamics in neural development and ciliogenesis. Its function is associated with three adjacent actin binding WASP Homology 2 (WH2) domains. We showed that these WH2 repeats confer multifunctional regulation
Autor:
Marek Orzechowski, Roger Craig, John Trinick, Lucian Barbu-Tudoran, William Lehman, Howard D. White, Shixin Yang
Publikováno v:
Biophysical Journal. 106(4):855-864
Muscle contraction is regulated by troponin-tropomyosin, which blocks and unblocks myosin binding sites on actin. To elucidate this regulatory mechanism, the three-dimensional organization of troponin and tropomyosin on the thin filament must be dete
Autor:
John Trinick, Helmut Wieczorek, Clair Phillips, Stephen P. Muench, Markus Huss, Sjors H.W. Scheres, Olga Vitavska, Michael A. Harrison
Publikováno v:
Journal of Molecular Biology
The vacuolar H+-ATPase (V-ATPase) is an ATP-driven proton pump essential to the function of eukaryotic cells. Its cytoplasmic V1 domain is an ATPase, normally coupled to membrane-bound proton pump Vo via a rotary mechanism. How these asymmetric motor
Publikováno v:
Biophysical Journal. 99:3336-3344
We have studied the shape of myosin VI, the actin minus-end directed motor, by negative stain and metal shadow electron microscopy. Single particle processing was used to make two-dimensional averages of the stain images, which greatly increases the