Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John Tkaczynski"'
Autor:
Elizabeth Tkaczynski, Abinaya Arulselvan, John Tkaczynski, Stephen Avery, Liqing Xiao, Beverly Torok-Storb, Kraig Abrams, Narayanam V. Rao, Gregory Johnson, Thomas P. Kennedy, Mortimer Poncz, Michele P. Lambert
Publikováno v:
Blood Advances, Vol 2, Iss 7, Pp 754-761 (2018)
Abstract: Thrombocytopenia is a significant complication of chemotherapy and radiation therapy. Platelet factor 4 (PF4; CXCL4) is a negative paracrine of megakaryopoiesis. We have shown that PF4 levels are inversely related to steady-state platelet c
Externí odkaz:
https://doaj.org/article/4b85415beb2e418f91dface3b15ff817
Autor:
Mortimer Poncz, Liqing Xiao, Michele P. Lambert, Elizabeth Tkaczynski, Thomas P. Kennedy, Abinaya Arulselvan, Kraig Abrams, Stephen Avery, John Tkaczynski, Beverly Torok-Storb, Gregory Johnson, Narayanam V. Rao
Thrombocytopenia is a significant complication of chemotherapy and radiation therapy. Platelet factor 4 (PF4; CXCL4) is a negative paracrine of megakaryopoiesis. We have shown that PF4 levels are inversely related to steady-state platelet counts, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdce248f09c235e36a321d60498d8655
https://europepmc.org/articles/PMC5894257/
https://europepmc.org/articles/PMC5894257/
Autor:
Rodney M. Camire, John Tkaczynski, Danuta Jarocha, Denise E. Sabatino, Mortimer Poncz, Randolph B. Lyde, Hyun Sook Ahn, Deborah L. French, Karen K. Vo, Spencer K. Sullivan, Elsa Treffeisen
Publikováno v:
Blood advances. 3(9)
B-domainless factor VIII (FVIII) ectopically expressed in megakaryocytes (MKs) is stored in α granules of platelets (pFVIII) and is capable of restoring hemostasis in FVIIInull mice, even in the presence of circulating inhibitors. However, our prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7736679ae7d53b47302efbf237b5467c
https://pubmed.ncbi.nlm.nih.gov/31036722
https://pubmed.ncbi.nlm.nih.gov/31036722
Autor:
Victoria Stepanova, Mortimer Poncz, Khalil Bdeir, Sergei Zaitsev, Hyunsook Ahn, Douglas B. Cines, John Tkaczynski
Publikováno v:
Blood. 134:3627-3627
We have been interested in developing fibrinolytic agents that have a prolonged half-life and can selectively prevent new thrombi from forming without destabilizing established hemostatic clots. We believe that platelet-targeting of urokinase plasmin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba119c3984969df3ab05af664e437a59
https://doi.org/10.1182/blood-2019-124501
https://doi.org/10.1182/blood-2019-124501
Autor:
Deborah L. French, Rodney M. Camire, Denise E. Sabatino, Sara Borst, Francis Ayombil, Hyunsook Ahn, Mortimer Poncz, Paul Gadue, John Tkaczynski, Randolph B. Lyde
Publikováno v:
Blood. 134:1102-1102
Human platelets endocytose coagulation factor (F) V into their α-granules, in part, via low-density lipoprotein (LDL) receptor-related protein 1 (LRP1). In contrast to humans, mouse FV is endogenously expressed during megakaryopoiesis and stored in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c4940ddc34337e170d037505cc6cde
https://doi.org/10.1182/blood-2019-124788
https://doi.org/10.1182/blood-2019-124788