Zobrazeno 1 - 10
of 29
pro vyhledávání: '"John Tisdale"'
Autor:
Samuel Lessard, Pauline Rimmelé, Hui Ling, Kevin Moran, Benjamin Vieira, Yi-Dong Lin, Gaurav Manohar Rajani, Vu Hong, Andreas Reik, Richard Boismenu, Ben Hsu, Michael Chen, Bettina M. Cockroft, Naoya Uchida, John Tisdale, Asif Alavi, Lakshmanan Krishnamurti, Mehrdad Abedi, Isobelle Galeon, David Reiner, Lin Wang, Anne Ramezi, Pablo Rendo, Mark C. Walters, Dana Levasseur, Robert Peters, Timothy Harris, Alexandra Hicks
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract BIVV003 is a gene-edited autologous cell therapy in clinical development for the potential treatment of sickle cell disease (SCD). Hematopoietic stem cells (HSC) are genetically modified with mRNA encoding zinc finger nucleases (ZFN) that ta
Externí odkaz:
https://doaj.org/article/eeb0c50036ba4eed80ba42d7f6cae1af
Autor:
Daima Bukini, Julie Makani, Joseph McCune, Dennis Lee, Cathy Bansbach, Serena De Vita, Dominic Kemps, Elianna Amin, Jonathan Spector, John Tisdale
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101287- (2024)
Therapeutic innovation to address sickle cell disease (SCD) is at a historical apex, characterized by a drug discovery, development, and commercialization landscape that includes potentially curative gene therapies. Given the wide geographic distribu
Externí odkaz:
https://doaj.org/article/61e617179782482faff6d68ead4aa67b
Autor:
Vandana Sachdev, Matthew Hsieh, Neal Jeffries, Anna Noreuil, Wen Li, Stanislav Sidenko, Hwaida Hannoush, Emily Limerick, Delon Wilson, John Tisdale, Courtney Fitzhugh
Publikováno v:
Blood Advances, Vol 3, Iss 19, Pp 2816-2824 (2019)
Abstract: Cardiac complications have been well-described in sickle cell disease; however, it has been rare to see improvements in cardiac abnormalities following any interventions. Previous work has shown no significant structural changes after treat
Externí odkaz:
https://doaj.org/article/8da1e581e46246b094bf63c630c77fea
Autor:
Pedro Réu, Azadeh Khosravi, Samuel Bernard, Jeff E. Mold, Mehran Salehpour, Kanar Alkass, Shira Perl, John Tisdale, Göran Possnert, Henrik Druid, Jonas Frisén
Publikováno v:
Cell Reports, Vol 20, Iss 4, Pp 779-784 (2017)
The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other h
Externí odkaz:
https://doaj.org/article/d5fc57428b2e4a8db888448776497858
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67189 (2013)
Non-Fc-binding Anti CD3 antibody has proven successful in reverting diabetes in the non-obese diabetes mouse model of type 1 diabetes and limited efficacy has been observed in human clinical trials. We hypothesized that addition of rapamycin, an mTOR
Externí odkaz:
https://doaj.org/article/470e357e8eee443d894e89877c3017e0
Autor:
Sunita Goyal, John Tisdale, Manfred Schmidt, Julie Kanter, Jennifer Jaroscak, Dustin Whitney, Hans Bitter, Philip D. Gregory, Geoffrey Parsons, Marianna Foos, Ashish Yeri, Maple Gioia, Sarah B. Voytek, Alex Miller, Jessie Lynch, Richard A. Colvin, Melissa Bonner
Publikováno v:
New England Journal of Medicine. 386:138-147
Gene therapy with LentiGlobin for sickle cell disease (bb1111, lovotibeglogene autotemcel) consists of autologous transplantation of a patient's hematopoietic stem cells transduced with the BB305 lentiviral vector that encodes the β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c569565a085a6ac43cd7ce4d2e7a40ac
https://doi.org/10.1056/nejmoa2109167
https://doi.org/10.1056/nejmoa2109167
Autor:
Nathan Bicher, Pranusha Pinna, Nathan Lightfoot, Gina Norato, Matthew Hsieh, John Tisdale, John K Lynch
Publikováno v:
Stroke. 54
Introduction: Symptomatic and silent cerebral infarcts (SCIs) are common in children and adults with sickle cell disease (SCD). SCIs are associated with cognitive performance and risk of future symptomatic stroke. The incidence of overt stroke and SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::171bdd1b0a65bba4d6ad954d8aef3dfd
https://doi.org/10.1161/str.54.suppl_1.tp178
https://doi.org/10.1161/str.54.suppl_1.tp178
Autor:
Thiyagaraj Mayuranathan, Gregory A. Newby, Ruopeng Feng, Yu Yao, Kalin Mayberry, Guolian Kang, Cicera Lazzarotto, Yichao Li, Rachel Levine, Erin Dempsey, Shaina N. Porter, Phillip A Doerfler, Jingjing Zhang, Yoonjeong Jang, Senthil Bhoopalan, Nikitha Nimmagadda, Akshay Sharma, John Tisdale, Shondra Miller, Yong Cheng, Shengdar Tsai, Mitchell J. Weiss, David R. Liu, Jonathan S Yen
Publikováno v:
Blood. 140:7784-7785
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e02951489bdc7c540d5a2fc7ff05d87e
https://doi.org/10.1182/blood-2022-162639
https://doi.org/10.1182/blood-2022-162639
Autor:
Akshay Sharma, John P Manis, David G. Justus, David A. Williams, Sergey Efuni, Ji Hyun Lee, Erin Conlin, Shawn Rose, Jeffrey Humphrey, Kirk Bertelsen, Nicole Henry, June Li, Donald Pardy, David Santos, Christian Zdybowicz, Alexis Leonard, John Tisdale
Publikováno v:
Blood. 140:8263-8264
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee6899f6ca66228ecf11e31e995b1db1
https://doi.org/10.1182/blood-2022-159728
https://doi.org/10.1182/blood-2022-159728
Autor:
Anusha Vittal, Hawwa Alao, Julian Hercun, Bashar Sharma, Arsalan Khan, Disha Sharma, Wilson Lee, Devika Kapuria, Matthew Hsieh, John Tisdale, Courtney Fitzhugh, David Kleiner, Elliot Levy, Richard Chang, Anna Conrey, Elenita Rivera, Amy Huang, Gil Ben Yakov, Gregory J. Kato, Mark T. Gladwin, Swee Lay Thein, Christopher Koh, Theo Heller
Publikováno v:
Am J Hematol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45bf83dfd67486b53be554ca02fcf89
https://europepmc.org/articles/PMC9942185/
https://europepmc.org/articles/PMC9942185/
