Graph-pMHC: Graph Neural Network Approach to MHC Class II Peptide Presentation and Antibody Immunogenicity

Autor: William John Thrift, Jason Perera, Sivan Cohen, Nicolas W. Lounsbury, Hem Gurung, Chris Rose, Jieming Chen, Suchit Jhunjhunwala, Kai Liu

Antigen presentation on MHC Class II (pMHCII presentation) plays an essential role in the adaptive immune response to extracellular pathogens and cancerous cells. But it can also reduce the efficacy of large-molecule drugs by triggering an anti-drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5d01bac6c83fbb025a6afb2970c2cef
https://doi.org/10.1101/2023.01.19.524779

Advancing Biologics Development Programs with Legacy Cell Lines: Advantages and Limitations of Genetic Testing for Addressing Clonality Concerns Prior to Availability of Late Stage Process and Product Consistency Data

Autor: Thomas Jostock, Chris Campbell, Karin Anderson, Ren Liu, Yuan Zhu, Juhi Ojha, Zhimei Du, Rolf Koehler, Robyn Emmins, Howard Clarke, Louise Almond, Paul Wu, Christina S. Alves, John Thrift, Michael W. Laird, David E. Shaw, Taymar Hartman, Jennitte Stevens

Publikováno v: PDA Journal of Pharmaceutical Science and Technology. 74:264-274

The bioprocessing industry uses recombinant mammalian cell lines to generate therapeutic biologic drugs. To ensure consistent product quality of the therapeutic proteins, it is imperative to have a controlled production process. Regulatory agencies a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a669404104723d3fb09a0ccb5078f2
https://doi.org/10.5731/pdajpst.2018.009316

Longitudinal Monitoring of Biofilm Formation via Robust Surface-Enhanced Raman Scattering Quantification of Pseudomonas aeruginosa-Produced Metabolites

Autor: Cuong Quoc Nguyen, Robert N. Sanderson, Regina Ragan, Filippo Capolino, Pierre Baldi, Mahsa Darvishzadeh-Varcheie, Katrine Whiteson, Arunima Bhattacharjee, Allon I. Hochbaum, Saba Ranjbar, Tara Gallagher, William John Thrift

Publikováno v: ACS Applied Materials & Interfaces. 10:12364-12373

Detection of bacterial metabolites at low concentrations in fluids with complex background allows for applications ranging from detecting biomarkers of respiratory infections to identifying contaminated medical instruments. Surface-enhanced Raman sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5413fc2a74889dc7a61af0890f73f6a5
https://doi.org/10.1021/acsami.7b18592

Driving Chemical Reactions in Plasmonic Nanogaps with Electrohydrodynamic Flow

Autor: Siavash Zare, Mahsa Darvishzadeh-Varcheie, Robert N. Sanderson, Torin J. Dupper, Allon I. Hochbaum, Nicholas Sharac, Regina Ragan, Mohammad Javad Abdolhosseini Qomi, Filippo Capolino, Cuong Quoc Nguyen, William John Thrift

Publikováno v: ACS nano, vol 11, iss 11
Thrift, WJ; Nguyen, CQ; Darvishzadeh-Varcheie, M; Zare, S; Sharac, N; Sanderson, RN; et al.(2017). Driving Chemical Reactions in Plasmonic Nanogaps with Electrohydrodynamic Flow. ACS NANO, 11(11), 11317-11329. doi: 10.1021/acsnano.7b05815. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/15b196kh

Nanoparticles from colloidal solution-with controlled composition, size, and shape-serve as excellent building blocks for plasmonic devices and metasurfaces. However, understanding hierarchical driving forces affecting the geometry of oligomers and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c52d0a33838e62233ed4260716bd1a
https://doi.org/10.1021/acsnano.7b05815

Improved regressions with convolutional neural networks for surface enhanced Raman scattering sensing of metabolite biomarkers

Autor: Junlin Wang, Jason Ernest Kahn, Ruijun Dong, Andrew Benjamin Laird, William John Thrift, Cuong Quoc Nguyen, Regina Ragan

Publikováno v: Nanoengineering: Fabrication, Properties, Optics, Thin Films, and Devices XVI.

Surface enhanced Raman scattering (SERS) is a vibrational spectroscopy method that enables the quantification of the concentration of small molecules. SERS sensing has been demonstrated in a wide variety of applications, from explosive and drug detec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c425cbd6708fd39fbb6cbf57e149beb3
https://doi.org/10.1117/12.2535410