Zobrazeno 1 - 10
of 25
pro vyhledávání: '"John Th'ng"'
Autor:
Gareth N. Corry, Juan Ausió, Darin McDonald, Hilmar Strickfaden, John Th'ng, Michèle Rouleau, Guy G. Poirier, Toyotaka Ishibashi, Jean-François Haince, Michael J. Kruhlak, D. Alan Underhill, Michael J. Hendzel
Publikováno v:
Journal of Biological Chemistry. 291:1789-1802
Chromatin undergoes a rapid ATP-dependent, ATM and H2AX-independent decondensation when DNA damage is introduced by laser microirradiation. Although the detailed mechanism of this decondensation remains to be determined, the kinetics of decondensatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f2251062c96d8af434f9104df9c3f0
https://doi.org/10.1074/jbc.m115.694992
https://doi.org/10.1074/jbc.m115.694992
Autor:
John Th'ng, Darin McDonald, Jeffrey J. Hayes, Michael J. Hendzel, He Fang, Nikhil Raghuram, Kylie Williams, Hilmar Strickfaden, Craig A. Mizzen
Publikováno v:
The Journal of Cell Biology
The prolyl isomerase Pin1 stimulates the dephosphorylation of histone H1, stabilizing its binding to chromatin at transcriptionally active chromatin.
Histone H1 plays a crucial role in stabilizing higher order chromatin structure. Transcriptiona
Histone H1 plays a crucial role in stabilizing higher order chromatin structure. Transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942069accd16e424c2d3e276cfc489fa
https://doi.org/10.1083/jcb.201305159
https://doi.org/10.1083/jcb.201305159
Autor:
John Th’ng, Jesse M. Walker, Ruiyao Wang, Alexis McEwan, Christine Gottardo, Gregory J. Spivak, Mary Lynn Tassotto, Roxanne Pycko
Publikováno v:
European Journal of Inorganic Chemistry. 2009:4629-4633
The [tris(pyrazolyl)methane]ruthenium complexes [(κ3-tpm)RuCl(solv)2]PF6 [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(κ3-tpm)RuCl(LL)]PF6 [LL = κ2-dppe, κ2-dppp, κ2-dppb, (PMePh2)2] have been prepared, characterized and screened in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd731898cb3c839dc674b8f46f5ddca0
https://doi.org/10.1002/ejic.200900766
https://doi.org/10.1002/ejic.200900766
Autor:
Manjinder S. Cheema, Michael J. Hendzel, Jordana B. Hutchinson, Krystal Missiaen, Jason Wang, Rodrigo Gonzalez Romero, Juan Ausió, Ron M. Finn, John Th'ng
Publikováno v:
Bioscience Reports
The present study was to understand whether the globular or C-terminal linker histone domain is more important for its binding to chromatin. Using histone H1, with swapped domain orientation, we found that both domains are equally important for nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8be1cd0fdea0a49c25203b4b8eee7a
https://pubmed.ncbi.nlm.nih.gov/26182371
https://pubmed.ncbi.nlm.nih.gov/26182371
Autor:
Michel Roberge, Jim Nelson, Mary Dasso, Mark R. Flory, Natalie T. Rundle, Ruedi Aebersold, John Th'ng, Raymond J. Andersen, Jomon Joseph
Publikováno v:
ACS Chemical Biology. 1:443-450
Using a chemical genetics screen, we have identified ent-15-oxokaurenoic acid (EKA) as a chemical that causes prolonged mitotic arrest at a stage resembling prometaphase. EKA inhibits the association of the mitotic motor protein centromeric protein E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b613176858849a8f8a626b272b381a5e
https://doi.org/10.1021/cb600196w
https://doi.org/10.1021/cb600196w
Autor:
Alexey V. Sorokin, Poul H. Sorensen, Valentina Evdokimova, Maxim A. Skabkin, Christina Richard, Sergey Guryanov, Jonathan Yau, Lev P. Ovchinnikov, John Th'ng, Anastasia Selyutina, Igor V. Nazimov
Publikováno v:
The EMBO Journal. 24:3602-3612
YB-1 is a DNA/RNA-binding nucleocytoplasmic shuttling protein whose regulatory effect on many DNA- and RNA-dependent events is determined by its localization in the cell. Distribution of YB-1 between the nucleus and the cytoplasm is known to be depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddc019af9bdd614c860f998ef2ff1a7
https://doi.org/10.1038/sj.emboj.7600830
https://doi.org/10.1038/sj.emboj.7600830
Publikováno v:
Journal of Biological Chemistry. 280:27809-27814
H1 histones bind to DNA as they enter and exit the nucleosome. H1 histones have a tripartite structure consisting of a short N-terminal domain, a highly conserved central globular domain, and a lysine-and arginine-rich C-terminal domain. The C-termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43c5c977e1ccf3eb9c7b2eae45068dce
https://doi.org/10.1074/jbc.m501627200
https://doi.org/10.1074/jbc.m501627200
Publikováno v:
Nature. 408:873-876
The considerable length of DNA in eukaryotic genomes requires packaging into chromatin to fit inside the small dimensions of the cell nucleus. Histone H1 functions in the compaction of chromatin into higher order structures derived from the repeating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c719da5ff0b103095baae5f7632e79
https://doi.org/10.1038/35048603
https://doi.org/10.1038/35048603
Autor:
Milena Crosato, Nicholas Bertos, Nadine Pelletier, Jiahuai Han, Henry H.Q. Heng, Marko Vezmar, Xiang-Jiao Yang, Audrey H. Wang, John Th'ng
Publikováno v:
Molecular and Cellular Biology. 19:7816-7827
Histone acetylation plays an important role in regulating chromatin structure and thus gene expression. Here we describe the functional characterization of HDAC4, a human histone deacetylase whose C-terminal part displays significant sequence similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26a4981a22d349c81d6998c790f81bf
https://doi.org/10.1128/mcb.19.11.7816
https://doi.org/10.1128/mcb.19.11.7816
Autor:
David P. Bazett-Jones, Yves Raymond, Walter K. Nishioka, John Th'ng, Michael J. Hendzel, C. David Allis
Publikováno v:
Journal of Biological Chemistry. 273:24470-24478
Apoptosis plays an important role in the survival of an organism, and substantial work has been done to understand the signaling pathways that regulate this process. Characteristic changes in chromatin organization accompany apoptosis and are routine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9139a33b1861bfe6f790b558acf85a42
https://doi.org/10.1074/jbc.273.38.24470
https://doi.org/10.1074/jbc.273.38.24470