Zobrazeno 1 - 10
of 84
pro vyhledávání: '"John Tam"'
Autor:
Erum Razvi, Benjamin R. DiFrancesco, Gregory A. Wasney, Zachary A. Morrison, John Tam, Anick Auger, Perrin Baker, Noor Alnabelseya, Jacquelyn D. Rich, Piyanka Sivarajah, Gregory B. Whitfield, Joe J. Harrison, Roman A. Melnyk, Mark Nitz, P. Lynne Howell
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Biosynthesis of the Pel exopolysaccharide in Pseudomonas aeruginosa requires all seven genes of the pelABCDEFG operon. The periplasmic modification enzyme PelA contains a C-terminal deacetylase domain that is necessary for Pel-dependent biof
Externí odkaz:
https://doaj.org/article/b1f3f3737eb946da81f5127f4eeb2e68
Autor:
John Tam, Therwa Hamza, Bing Ma, Kevin Chen, Greg L. Beilhartz, Jacques Ravel, Hanping Feng, Roman A. Melnyk
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Clostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for
Externí odkaz:
https://doaj.org/article/25196c5f6826491d89346cd290d949ba
Autor:
Joseph S. Bresee, Zhao-Yin Fang, Bei Wang, E.A.S. Nelson, John Tam, Yati Soenarto, Siswanto Agus Wilopo, Paul Kilgore, Jung Soo Kim, Jung Oak Kang, Wong Swee Lan, Chan Lee Gaik, Kyaw Moe, Kow-Tong Chen, Chuleeporn Jiraphongsa, Yaowapa Pongsuwanna, Nguyen Van Man, Phan Van Tu, Le Thi Luan, Erik Hummelman, Jon R. Gentsch, Roger Glass
Publikováno v:
Emerging Infectious Diseases, Vol 10, Iss 6, Pp 988-995 (2004)
Rotavirus remains the most common cause of severe, dehydrating diarrhea among children worldwide. Several rotavirus vaccines are under development. Decisions about new vaccine introduction will require reliable data on disease impact. The Asian Rotav
Externí odkaz:
https://doaj.org/article/0e32f7e355aa4d75b9c2d5f4b4e2531b
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25268 (2011)
Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic
Externí odkaz:
https://doaj.org/article/8f070c97e44e4376b8fbfdfccd95d373
Autor:
Simoun Icho, Jennifer S. Ward, John Tam, Larry K. Kociolek, Casey M. Theriot, Roman A. Melnyk
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Intestinal bile acids play an essential role in the Clostridioides difficile lifecycle having been shown in vitro to modulate various aspects of pathogenesis, including spore germination, vegetative growth, and more recently the action of the primary
Publikováno v:
Infection and immunity. 90(8)
C. difficile infection (CDI) is a highly inflammatory disease mediated by the production of two large toxins that weaken the intestinal epithelium and cause extensive colonic tissue damage. Antibiotic alternative therapies for CDI are urgently needed
Autor:
Simoun Icho, Edurne Rujas, Krithika Muthuraman, John Tam, Huazhu Liang, Shelby Landreth, Mingmin Liao, Darryl Falzarano, Jean-Philippe Julien, Roman A. Melnyk
Publikováno v:
Addi. Archivo Digital para la Docencia y la Investigación
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
An essential step in the infection life cycle of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the proteolytic activation of the viral spike (S) protein, which enables membrane fusion and entry into the host cell. Two distinct c
Autor:
John Tam
This study investigates ATRP emulsion polymerization of butyl methacrylate (BMA) in a 2-L stirred tank reactor using AGET as the initiation technique with ascorbic acid. The polymerization is performed in two step procedure using surfactant (Brij 98)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6196518dca8b01a28acc7bf2ee4848c5
https://doi.org/10.32920/16814722.v1
https://doi.org/10.32920/16814722.v1
Publikováno v:
AIAA Aviation 2019 Forum.
Publikováno v:
International Journal of Data and Network Science, Vol 7, Iss 4, Pp 2013-2028 (2023)
This study aims to analyze the effect of transformational leadership (TL) on organizational citizenship behavior (OCB), the relationship between TL and performance, TL and IWB, Leader member exchange (LMX) and OCB, LMX and performance, LMX and innova
Externí odkaz:
https://doaj.org/article/546e18960c394aacb907b4db63a93a88